{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:48:19Z","timestamp":1791355699420,"version":"4.3.1"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Several direct target genes of the p53 tumor suppressor have been identified within pathways involved in viral sensing, cytokine production, and inflammation, suggesting a potential role of p53 in antiviral immunity. The increasing need to identify immune factors to devise host-targeted therapies against pandemic influenza A virus (IAV) led us to investigate the role of endogenous wild-type p53 on the immune response to IAV. We observed that the absence of p53 resulted in delayed cytokine and antiviral gene responses in lung and bone marrow, decreased dendritic cell activation, and reduced IAV-specific CD8+ T cell immunity. Consequently, p53\u2212\/\u2212 mice showed a more severe IAV-induced disease compared with their wild-type counterparts. These findings establish that p53 influences the antiviral response to IAV, affecting both innate and adaptive immunity. Thus, in addition to its established functions as a tumor suppressor gene, p53 serves as an IAV host antiviral factor that might be modulated to improve anti-IAV therapy and vaccines.<\/jats:p>","DOI":"10.4049\/jimmunol.1101459","type":"journal-article","created":{"date-parts":[[2011,11,22]],"date-time":"2011-11-22T07:21:45Z","timestamp":1321946505000},"page":"6428-6436","source":"Crossref","is-referenced-by-count":83,"title":["p53 Serves as a Host Antiviral Factor That Enhances Innate and Adaptive Immune Responses to Influenza A Virus"],"prefix":"10.1093","volume":"187","author":[{"given":"C\u00e9sar","family":"Mu\u00f1oz-Fontela","sequence":"first","affiliation":[{"name":"Department of Oncological Sciences, Mount Sinai School of Medicine , New York, NY 10029"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Pazos","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Mount Sinai School of Medicine , New York, NY 10029"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igotz","family":"Delgado","sequence":"additional","affiliation":[{"name":"Department of Oncological Sciences, Mount Sinai School of Medicine , New York, NY 10029"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Murk","sequence":"additional","affiliation":[{"name":"Department of Oncological Sciences, Mount Sinai School of Medicine , New York, NY 10029"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sathish Kumar","family":"Mungamuri","sequence":"additional","affiliation":[{"name":"Department of Oncological Sciences, Mount Sinai School of Medicine , New York, NY 10029"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam W","family":"Lee","sequence":"additional","affiliation":[{"name":"Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School , Charlestown, MA 02129"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Garc\u00eda-Sastre","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Mount Sinai School of Medicine , New York, NY 10029"},{"name":"Division of Infectious Diseases, Department of Medicine, Mount Sinai School of Medicine , New York, NY 10029"},{"name":"Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine , New York, NY 10029"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M","family":"Moran","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Mount Sinai School of Medicine , New York, NY 10029"},{"name":"Immunology Institute, Mount Sinai School of Medicine , New York, NY 10029"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart A","family":"Aaronson","sequence":"additional","affiliation":[{"name":"Department of Oncological Sciences, Mount Sinai School of Medicine , New York, NY 10029"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,12,15]]},"reference":[{"key":"2025032410534780400_r1","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/ni1343","article-title":"Influenza and the challenge for immunology","volume":"7","author":"Doherty","year":"2006","journal-title":"Nat. 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