{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:45:40Z","timestamp":1790509540443,"version":"4.1.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>IL-23R gene variants have been identified as risk factors for two major inflammatory bowel diseases (IBDs), Crohn\u2019s disease and ulcerative colitis, but how they contribute to disease is poorly understood. In this study, we show that the rs10889677 variant in the 3\u2032-untranslated region of the IL-23R gene displays enhanced levels of both mRNA and protein production of IL-23R. This can be attributed to a loss of binding capacity for the microRNAs (miRNAs) Let-7e and Let-7f by the variant allele. Indeed, inhibition and overexpression of these miRNAs influenced the expression of the wild type but not the variant allele. Our data clearly demonstrate a role for miRNA-mediated dysregulation of IL-23R signaling, correlated with a single nucleotide polymorphism in the IL-23R strongly associated with IBD susceptibility. This implies that this mutation, in combination with other genetic risk factors, can lead to disease through sustained IL-23R signaling, contributing to the chronicity of IBD.<\/jats:p>","DOI":"10.4049\/jimmunol.1101494","type":"journal-article","created":{"date-parts":[[2012,1,19]],"date-time":"2012-01-19T21:04:40Z","timestamp":1327007080000},"page":"1573-1577","source":"Crossref","is-referenced-by-count":95,"title":["Cutting Edge: A Variant of the\n                    <i>IL-23R<\/i>\n                    Gene Associated with Inflammatory Bowel Disease Induces Loss of MicroRNA Regulation and Enhanced Protein Production"],"prefix":"10.1093","volume":"188","author":[{"given":"Antonie","family":"Zwiers","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, VU University Medical Center , 1007 MB Amsterdam ,","place":["The Netherlands"]},{"name":"Department of Molecular Cell Biology and Immunology, VU University Medical Center , 1007 MB Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurens","family":"Kraal","sequence":"additional","affiliation":[{"name":"Department of Bioengineering and Therapeutic Sciences, University of California , San Francisco, San Francisco, CA 94143"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tineke C T M","family":"van de Pouw Kraan","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology and Immunology, VU University Medical Center , 1007 MB Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Wurdinger","sequence":"additional","affiliation":[{"name":"Department of Neurology, VU University Medical Center , 1007 MB Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Bouma","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, VU University Medical Center , 1007 MB Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Kraal","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology and Immunology, VU University Medical Center , 1007 MB Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,2,15]]},"reference":[{"key":"2025032409510344700_r1","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1126\/science.1135245","article-title":"A genome-wide association study identifies IL23R as an inflammatory bowel disease gene","volume":"314","author":"Duerr","year":"2006","journal-title":"Science"},{"key":"2025032409510344700_r2","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/ng.275","article-title":"Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study","volume":"41","author":"Silverberg","year":"2009","journal-title":"Nat. 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