{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:08:15Z","timestamp":1791288495015,"version":"4.3.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In this study, we describe a new population of NK cells that reside in the normal, uninflamed peritoneal cavity. Phenotypically, they share some similarities with the small population of CD49b\u2212, CD27+ immature splenic NK cells, as well as liver NK cells, but they differ in their expression of CD62L, TRAIL, and EOMES. Functionally, the peritoneal NK cells resemble the immature splenic NK cells in their production of IFN-\u03b3, GM-CSF, and TNF-\u03b1 and in the killing of YAC-1 target cells. We also found that the peritoneum induces different behavior in mature and immature splenic NK cells. When transferred i.v. into RAG\u03b3c knockout mice, both populations undergo homeostatic proliferation in the spleen, but only the immature splenic NK cells are able to reach the peritoneum. When transferred directly into the peritoneum, the mature NK cells survive but do not divide, whereas the immature NK cells proliferate profusely. These data suggest that the peritoneum is not only home to a new subset of tissue-resident NK cells, but that it differentially regulates the migration and homeostatic proliferation of immature versus mature NK cells.<\/jats:p>","DOI":"10.4049\/jimmunol.1101540","type":"journal-article","created":{"date-parts":[[2011,11,12]],"date-time":"2011-11-12T03:25:37Z","timestamp":1321068337000},"page":"6235-6242","source":"Crossref","is-referenced-by-count":26,"title":["Resident Peritoneal NK Cells"],"prefix":"10.1093","volume":"187","author":[{"given":"Rosemary","family":"Gonzaga","sequence":"first","affiliation":[{"name":"Ghost Laboratory, T Cell Memory and Tolerance Section, Laboratory of Cellular and Molecular Immunology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polly","family":"Matzinger","sequence":"additional","affiliation":[{"name":"Ghost Laboratory, T Cell Memory and Tolerance Section, Laboratory of Cellular and Molecular Immunology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ainhoa","family":"Perez-Diez","sequence":"additional","affiliation":[{"name":"Ghost Laboratory, T Cell Memory and Tolerance Section, Laboratory of Cellular and Molecular Immunology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,12,15]]},"reference":[{"key":"2025032410533838500_r1","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/ni1395","article-title":"A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127","volume":"7","author":"Vosshenrich","year":"2006","journal-title":"Nat. Immunol."},{"key":"2025032410533838500_r2","doi-asserted-by":"crossref","first-page":"4201","DOI":"10.1182\/blood-2007-04-087577","article-title":"Unique subset of natural killer cells develops from progenitors in lymph node","volume":"111","author":"Veinotte","year":"2008","journal-title":"Blood"},{"key":"2025032410533838500_r3","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.4049\/jimmunol.176.3.1517","article-title":"CD27 dissects mature NK cells into two subsets with distinct responsiveness and migratory capacity","volume":"176","author":"Hayakawa","year":"2006","journal-title":"J. Immunol."},{"key":"2025032410533838500_r4","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/ni796","article-title":"In vivo developmental stages in murine natural killer cell maturation","volume":"3","author":"Kim","year":"2002","journal-title":"Nat. Immunol."},{"key":"2025032410533838500_r5","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1600-065X.2006.00447.x","article-title":"Uterine natural killer cells: a specialized differentiation regulated by ovarian hormones","volume":"214","author":"Croy","year":"2006","journal-title":"Immunol. Rev."},{"key":"2025032410533838500_r6","doi-asserted-by":"crossref","first-page":"6140","DOI":"10.4049\/jimmunol.181.9.6140","article-title":"Unique receptor repertoire in mouse uterine NK cells","volume":"181","author":"Yadi","year":"2008","journal-title":"J. Immunol."},{"key":"2025032410533838500_r7","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1146\/annurev.immunol.24.021605.090700","article-title":"Natural killer cell developmental pathways: a question of balance","volume":"24","author":"Di Santo","year":"2006","journal-title":"Annu. Rev. Immunol."},{"key":"2025032410533838500_r8","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.coi.2005.01.005","article-title":"Distinguishing features of developing natural killer cells","volume":"17","author":"Vosshenrich","year":"2005","journal-title":"Curr. Opin. Immunol."},{"key":"2025032410533838500_r9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1600-065X.2006.00454.x","article-title":"Functional subsets of mouse natural killer cells","volume":"214","author":"Hayakawa","year":"2006","journal-title":"Immunol. Rev."},{"key":"2025032410533838500_r10","doi-asserted-by":"crossref","first-page":"4968","DOI":"10.4049\/jimmunol.0900907","article-title":"CD94 defines phenotypically and functionally distinct mouse NK cell subsets","volume":"183","author":"Yu","year":"2009","journal-title":"J. Immunol."},{"key":"2025032410533838500_r11","doi-asserted-by":"crossref","first-page":"5488","DOI":"10.1182\/blood-2008-10-187179","article-title":"Maturation of mouse NK cells is a 4-stage developmental program","volume":"113","author":"Chiossone","year":"2009","journal-title":"Blood"},{"key":"2025032410533838500_r12","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.4049\/jimmunol.174.4.2336","article-title":"Conditional macrophage ablation demonstrates that resident macrophages initiate acute peritoneal inflammation","volume":"174","author":"Cailhier","year":"2005","journal-title":"J. Immunol."},{"key":"2025032410533838500_r13","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/jcp.20732","article-title":"The macrophage heterogeneity: difference between mouse peritoneal exudate and splenic F4\/80+ macrophages","volume":"209","author":"Liu","year":"2006","journal-title":"J. Cell. Physiol."},{"key":"2025032410533838500_r14","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0065-2776(08)60512-X","article-title":"CD5 B cells, a fetal B cell lineage","volume":"55","author":"Hardy","year":"1994","journal-title":"Adv. Immunol."},{"key":"2025032410533838500_r15","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1084\/jem.191.4.731","article-title":"B1 B lymphocytes play a critical role in host protection against lymphatic filarial parasites","volume":"191","author":"Paciorkowski","year":"2000","journal-title":"J. Exp. Med."},{"key":"2025032410533838500_r16","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nature08636","article-title":"Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells","volume":"463","author":"Moro","year":"2010","journal-title":"Nature"},{"key":"2025032410533838500_r17","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/00024382-200302000-00010","article-title":"Natural killer cells participate in bacterial clearance during septic peritonitis through interactions with macrophages","volume":"19","author":"Godshall","year":"2003","journal-title":"Shock"},{"key":"2025032410533838500_r18","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.4049\/jimmunol.175.4.2152","article-title":"Characteristics of NK cell migration early after vaccinia infection","volume":"175","author":"Prlic","year":"2005","journal-title":"J. Immunol."},{"key":"2025032410533838500_r19","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1084\/jem.188.9.1611","article-title":"An essential role for tumor necrosis factor in natural killer cell-mediated tumor rejection in the peritoneum","volume":"188","author":"Smyth","year":"1998","journal-title":"J. Exp. Med."},{"key":"2025032410533838500_r20","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/j.1399-3089.2006.00348.x","article-title":"NK cells promote peritoneal xenograft rejection through an IFN-\u03b3-dependent mechanism","volume":"13","author":"Lin","year":"2006","journal-title":"Xenotransplantation"},{"key":"2025032410533838500_r21","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/76917","article-title":"Gamma chain required for naive CD4+ T cell survival but not for antigen proliferation","volume":"1","author":"Lantz","year":"2000","journal-title":"Nat. Immunol."},{"key":"2025032410533838500_r22","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/nprot.2006.107","article-title":"The JAM Test and its daughter P-JAM: simple tests of DNA fragmentation to measure cell death and stasis","volume":"1","author":"Usharauli","year":"2006","journal-title":"Nat. Protoc."},{"key":"2025032410533838500_r23","doi-asserted-by":"crossref","first-page":"5346","DOI":"10.1182\/blood-2006-10-051318","article-title":"CD4 cells can be more efficient at tumor rejection than CD8 cells","volume":"109","author":"Perez-Diez","year":"2007","journal-title":"Blood"},{"key":"2025032410533838500_r24","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1084\/jem.20021847","article-title":"In vivo survival and homeostatic proliferation of natural killer cells","volume":"197","author":"Prlic","year":"2003","journal-title":"J. Exp. Med."},{"key":"2025032410533838500_r25","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/ni1332","article-title":"T cell- and B cell-independent adaptive immunity mediated by natural killer cells","volume":"7","author":"O\u2019Leary","year":"2006","journal-title":"Nat. Immunol."},{"key":"2025032410533838500_r26","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.1073\/pnas.0609692104","article-title":"Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46","volume":"104","author":"Walzer","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032410533838500_r27","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1182\/blood-2004-08-3262","article-title":"TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver","volume":"105","author":"Takeda","year":"2005","journal-title":"Blood"},{"key":"2025032410533838500_r28","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/icb.2009.94","article-title":"A potential role for RAG-1 in NK cell development revealed by analysis of NK cells during ontogeny","volume":"88","author":"Andrews","year":"2010","journal-title":"Immunol. Cell Biol."},{"key":"2025032410533838500_r29","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S1074-7613(04)00076-7","article-title":"T-bet regulates the terminal maturation and homeostasis of NK and V\u03b114i NKT cells","volume":"20","author":"Townsend","year":"2004","journal-title":"Immunity"},{"key":"2025032410533838500_r30","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1600-065X.2007.00563.x","article-title":"The trafficking of natural killer cells","volume":"220","author":"Gr\u00e9goire","year":"2007","journal-title":"Immunol. Rev."},{"key":"2025032410533838500_r31","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1038\/ni1138","article-title":"Induced recruitment of NK cells to lymph nodes provides IFN-\u03b3 for TH1 priming","volume":"5","author":"Mart\u00edn-Fontecha","year":"2004","journal-title":"Nat. Immunol."},{"key":"2025032410533838500_r32","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/S0015-0282(16)55224-8","article-title":"The natural killer activity of peritoneal fluid lymphocytes is decreased in women with endometriosis","volume":"58","author":"Oosterlynck","year":"1992","journal-title":"Fertil. Steril."},{"key":"2025032410533838500_r33","doi-asserted-by":"crossref","first-page":"200","DOI":"10.2174\/092986711794088416","article-title":"Role of natural killer cell activity in the pathogenesis of endometriosis","volume":"18","author":"Sikora","year":"2011","journal-title":"Curr. Med. Chem."},{"key":"2025032410533838500_r34","doi-asserted-by":"crossref","first-page":"6637","DOI":"10.4049\/jimmunol.0902784","article-title":"Increased hematopoietic cells in the mertk\u2212\/\u2212 mouse peritoneal cavity: a result of augmented migration","volume":"184","author":"Williams","year":"2010","journal-title":"J. Immunol."},{"key":"2025032410533838500_r35","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S1074-7613(01)00257-6","article-title":"CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity","volume":"16","author":"Ansel","year":"2002","journal-title":"Immunity"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/187\/12\/6235\/61605992\/1101540.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/187\/12\/6235\/61605992\/1101540.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T03:15:58Z","timestamp":1743131758000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/187\/12\/6235\/7977278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":35,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1101540","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.13371982.14742088","asserted-by":"object"}]},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2011,12]]},"published":{"date-parts":[[2011,12]]}}}