{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:07:40Z","timestamp":1761059260957,"version":"3.40.3"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In mice lacking IL-15, NK cell development is arrested at immature stages, providing an opportunity to investigate the earliest developing NK cells that would respond to IL-15. We show in this study that immature NK cells were present in the spleen as well as bone marrow (BM) and contained IL-15\u2013high-responder cells. Thus, mature NK cells were generated more efficiently from IL-15\u2212\/\u2212 than from control donor cells in radiation BM chimeras, and the rate of IL-15\u2013induced cell division in vitro was higher in NK cells in the spleen and BM from IL-15\u2212\/\u2212 mice than in those from wild-type mice. Phenotypically, NK cells developed in IL-15\u2212\/\u2212 mice up to the minor but discrete CD11b\u2013CD27+DX5hiCD51dullCD127dullCD122hi stage, which contained the majority of Ly49G2+ and D+ NK cells both in the spleen and BM. Even among wild-type splenic NK cells, IL-15\u2013induced proliferation was most prominent in CD11b\u2013DX5hi cells. Notably, IL-15\u2013mediated preferential expansion (but not conversion from Ly49\u2013 cells) of Ly49+ NK cells was observed in vitro only for NK cells in the spleen. These observations indicated the uneven distribution of NK cells of different developing stages with variable IL-15 responsiveness in these lymphoid organs. Immature NK cells in the spleen may contribute, as auxiliaries to those in BM, to the mature NK cell compartment through IL-15\u2013driven extramarrow expansion under steady-state or inflammatory conditions.<\/jats:p>","DOI":"10.4049\/jimmunol.1101561","type":"journal-article","created":{"date-parts":[[2011,10,4]],"date-time":"2011-10-04T04:48:30Z","timestamp":1317703710000},"page":"5162-5169","source":"Crossref","is-referenced-by-count":11,"title":["IL-15\u2013High-Responder Developing NK Cells Bearing Ly49 Receptors in IL-15\u2212\/\u2212 Mice"],"prefix":"10.1093","volume":"187","author":[{"given":"Katsumi","family":"Yoshizawa","sequence":"first","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Shinshu University Graduate School of Medicine , Matsumoto 390-8621 ,","place":["Japan"]},{"name":"Department of Surgery, School of Medicine, Shinshu University , Matsumoto 390-8621 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsuke","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Shinshu University Graduate School of Medicine , Matsumoto 390-8621 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Notake","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Shinshu University Graduate School of Medicine , Matsumoto 390-8621 ,","place":["Japan"]},{"name":"Department of Surgery, School of Medicine, Shinshu University , Matsumoto 390-8621 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-Ichi","family":"Miyagawa","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Medicine, Shinshu University , Matsumoto 390-8621 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeaki","family":"Hida","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Shinshu University Graduate School of Medicine , Matsumoto 390-8621 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsuke","family":"Taki","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Shinshu University Graduate School of Medicine , Matsumoto 390-8621 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,11,15]]},"reference":[{"key":"2025032410460351200_r1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1146\/annurev.immunol.24.021605.090700","article-title":"Natural killer cell developmental pathways: a question of balance","volume":"24","author":"Di Santo","year":"2006","journal-title":"Annu. 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