{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:28:57Z","timestamp":1791332937107,"version":"4.3.1"},"reference-count":83,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Recruitment of virus-infected T lymphocytes into the CNS is an essential step in the development of virus-associated neuroinflammatory diseases, notably myelopathy induced by retrovirus human T leukemia virus-1 (HTLV-1). We have recently shown the key role of collapsin response mediator protein 2 (CRMP2), a phosphoprotein involved in cytoskeleton rearrangement, in the control of human lymphocyte migration and in brain targeting in animal models of virus-induced neuroinflammation. Using lymphocytes cloned from infected patients and chronically infected T cells, we found that HTLV-1 affects CRMP2 activity, resulting in an increased migratory potential. Elevated CRMP2 expression accompanies a higher phosphorylation level of CRMP2 and its more pronounced adhesion to tubulin and actin. CRMP2 forms, a full length and a shorter, cleaved one, are also affected. Tax transfection and extinction strategies show the involvement of this viral protein in enhanced full-length and active CRMP2, resulting in prominent migratory rate. A role for other viral proteins in CRMP2 phosphorylation is suspected. Full-length CRMP2 confers a migratory advantage possibly by preempting the negative effect of short CRMP2 we observe on T lymphocyte migration. In addition, HTLV-1\u2013induced migration seems, in part, supported by the ability of infected cell to increase the proteosomal degradation of short CRMP2. Finally, gene expression in CD69+ cells selected from patients suggests that HTLV-1 has the capacity to influence the CRMP2\/PI3K\/Akt axis thus to positively control cytoskeleton organization and lymphocyte migration. Our data provide an additional clue to understanding the infiltration of HTLV-1\u2013infected lymphocytes into various tissues and suggest that the regulation of CRMP2 activity by virus infection is a novel aspect of neuroinflammation.<\/jats:p>","DOI":"10.4049\/jimmunol.1101562","type":"journal-article","created":{"date-parts":[[2012,1,7]],"date-time":"2012-01-07T05:58:42Z","timestamp":1325915922000},"page":"1222-1233","source":"Crossref","is-referenced-by-count":41,"title":["Human T Lymphotropic Virus Type 1 Increases T Lymphocyte Migration by Recruiting the Cytoskeleton Organizer CRMP2"],"prefix":"10.1093","volume":"188","author":[{"given":"Michel","family":"Varrin-Doyer","sequence":"first","affiliation":[{"name":"INSERM U1028, Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 5292, Centre de Recherche en Neuroscience de Lyon, Equipe Neurooncologie-Neuroinflammation , F-69000 Lyon ,","place":["France"]},{"name":"University of Lyon , F-69000 Lyon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeline","family":"Nicolle","sequence":"additional","affiliation":[{"name":"INSERM U1028, Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 5292, Centre de Recherche en Neuroscience de Lyon, Equipe Neurooncologie-Neuroinflammation , F-69000 Lyon ,","place":["France"]},{"name":"University of Lyon , F-69000 Lyon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Marignier","sequence":"additional","affiliation":[{"name":"INSERM U1028, Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 5292, Centre de Recherche en Neuroscience de Lyon, Equipe Neurooncologie-Neuroinflammation , F-69000 Lyon ,","place":["France"]},{"name":"University of Lyon , F-69000 Lyon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Cavagna","sequence":"additional","affiliation":[{"name":"INSERM U1028, Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 5292, Centre de Recherche en Neuroscience de Lyon, Equipe Neurooncologie-Neuroinflammation , F-69000 Lyon ,","place":["France"]},{"name":"University of Lyon , F-69000 Lyon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Benetollo","sequence":"additional","affiliation":[{"name":"INSERM U1028, Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 5292, Centre de Recherche en Neuroscience de Lyon, Equipe Neurooncologie-Neuroinflammation , F-69000 Lyon ,","place":["France"]},{"name":"University of Lyon , F-69000 Lyon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Wattel","sequence":"additional","affiliation":[{"name":"Oncovirologie et Bioth\u00e9rapies, Universit\u00e9 Claude Bernard Lyon 1, Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 5239, Centre L\u00e9on B\u00e9rard , 69008 Lyon, France ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Giraudon","sequence":"additional","affiliation":[{"name":"INSERM U1028, Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 5292, Centre de Recherche en Neuroscience de Lyon, Equipe Neurooncologie-Neuroinflammation , F-69000 Lyon ,","place":["France"]},{"name":"University of Lyon , F-69000 Lyon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,2,1]]},"reference":[{"key":"2025032409480958000_r1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/448421a","article-title":"Inflammatory disease: assault on the guardian","volume":"448","author":"Ransohoff","year":"2007","journal-title":"Nature"},{"key":"2025032409480958000_r2","doi-asserted-by":"crossref","first-page":"6476","DOI":"10.1073\/pnas.78.10.6476","article-title":"Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera","volume":"78","author":"Hinuma","year":"1981","journal-title":"Proc. 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