{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:49:44Z","timestamp":1790232584408,"version":"4.1.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>MicroRNAs govern immune responses to infectious agents, allergens, and autoantigens and function by posttranscriptional repression of their target genes. In this paper, we have addressed the role of microRNA-155 (miR-155) in the control of Helicobacter pylori infection of the gastrointestinal tract and the development of H. pylori-induced chronic gastritis and associated gastric preneoplastic pathology. We show that miR-155 is upregulated in the gastric mucosa of experimentally infected mice and that miR-155\u2212\/\u2212 mice fail to control H. pylori infection as a result of impaired pathogen-specific Th1 and Th17 responses. miR-155\u2212\/\u2212 mice are also less well protected against challenge infection after H. pylori-specific vaccination than their wild-type (wt) counterparts. As a consequence of their impaired T cell responses to H. pylori, miR-155\u2212\/\u2212 mice develop less severe infection-induced immunopathology manifesting as chronic atrophic gastritis, epithelial hyperplasia, and intestinal metaplasia. T cells from miR-155\u2212\/\u2212 mice that are activated by CD3\/CD28 cross-linking expand less and produce less IFN-\u03b3 and IL-17 than wt T cells. Finally, we show in this paper using adoptive transfers that the phenotypes of miR-155\u2212\/\u2212 mice are likely due to T cell-intrinsic defects. In contrast to wt T cells, miR-155\u2212\/\u2212 T cells from infected donors do not control H. pylori infections in T cell-deficient recipients, do not differentiate into Th1 or Th17 cells, and do not cause immunopathology. In addition, naive miR-155\u2212\/\u2212 T cells fail to induce chronic Th17-driven colitis in an adoptive transfer model. In conclusion, miR-155 expression is required for the Th17\/Th1 differentiation that underlies immunity to H. pylori infection on the one hand and infection-associated immunopathology on the other.<\/jats:p>","DOI":"10.4049\/jimmunol.1101772","type":"journal-article","created":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T11:41:52Z","timestamp":1314877312000},"page":"3578-3586","source":"Crossref","is-referenced-by-count":131,"title":["MicroRNA-155 Is Essential for the T Cell-Mediated Control of <i>Helicobacter pylori<\/i> Infection and for the Induction of Chronic Gastritis and Colitis"],"prefix":"10.1093","volume":"187","author":[{"given":"Mathias","family":"Oertli","sequence":"first","affiliation":[{"name":"Institute of Molecular Cancer Research, University of Zurich , 8057 Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela B","family":"Engler","sequence":"additional","affiliation":[{"name":"Institute of Molecular Cancer Research, University of Zurich , 8057 Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Kohler","sequence":"additional","affiliation":[{"name":"Institute of Molecular Cancer Research, University of Zurich , 8057 Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Max Planck Institute for Infection Biology , 10117 Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Max Planck Institute for Infection Biology , 10117 Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Institute of Molecular Cancer Research, University of Zurich , 8057 Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,10,1]]},"reference":[{"key":"2025032410390236700_r1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nri2708","article-title":"Physiological and pathological roles for microRNAs in the immune system","volume":"10","author":"O\u2019Connell","year":"2010","journal-title":"Nat. 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