{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T12:00:14Z","timestamp":1771588814270,"version":"3.50.1"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The adaptive immune system generates memory cells, which induce a rapid and robust immune response following secondary Ag encounter. Memory CD8+ T cells are a critical component of protective immunity against infections and cancers. Therefore, understanding the mechanism whereby memory CD8+ T cells are generated and maintained is important for inducing effective memory CD8+ T cell response. Recent studies have demonstrated that the inflammatory cytokine IL-12 favors the generation of terminal effector CD8+ T cells rather than memory precursor effector CD8+ T cells by regulating the expression of the transcription factor T-bet. In this study, we report that the inflammatory cytokine osteopontin (Opn) modulates memory CD8+ T cell generation during influenza virus infection. Although Opn wild-type and Opn knockout (KO) mice had similar numbers of virus-specific effector CD8+ T cells, virus-specific effector CD8+ T cells generated in Opn KO mice showed low levels of T-bet expression and an increased memory precursor cell population compared with cells generated in Opn wild-type mice. This resulted in the persistently increased number of memory CD8+ T cells in Opn KO mice. Studies with bone marrow-derived dendritic cells demonstrated that Opn deficiency in bone marrow-derived dendritic cells results in low levels of IL-12 production in response to the stimulation with influenza virus. Thus, we hypothesize that Opn modulates the generation of memory precursor effector CD8+ T cells by regulating cytokine milieu during the acute phase of virus infection. This finding may provide new insight into the role of Opn in adaptive immune response.<\/jats:p>","DOI":"10.4049\/jimmunol.1101825","type":"journal-article","created":{"date-parts":[[2011,10,22]],"date-time":"2011-10-22T04:32:19Z","timestamp":1319257939000},"page":"5671-5683","source":"Crossref","is-referenced-by-count":18,"title":["Osteopontin Modulates the Generation of Memory CD8+ T Cells during Influenza Virus Infection"],"prefix":"10.1093","volume":"187","author":[{"given":"Junko","family":"Morimoto","sequence":"first","affiliation":[{"name":"Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University , Sapporo 060-0815 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayoko","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Bioresources, Research Center for Zoonosis Control, Hokkaido University , Sapporo 001-0020 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Bioresources, Research Center for Zoonosis Control, Hokkaido University , Sapporo 001-0020 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiemi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University , Sapporo 060-0815 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiichi","family":"Kajino","sequence":"additional","affiliation":[{"name":"Department of Collaboration and Education, Research Center for Zoonosis Control, Hokkaido University , Sapporo 001-0020 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Matsui","sequence":"additional","affiliation":[{"name":"Department of Matrix Medicine, Institute for Genetic Medicine, Hokkaido University , Sapporo 060-0815 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadaaki","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University , Sapporo 060-0815 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshimitsu","family":"Uede","sequence":"additional","affiliation":[{"name":"Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University , Sapporo 060-0815 ,","place":["Japan"]},{"name":"Department of Matrix Medicine, Institute for Genetic Medicine, Hokkaido University , Sapporo 060-0815 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,12,1]]},"reference":[{"key":"2025032410492567900_r1","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/ni1105","article-title":"CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection","volume":"5","author":"Sun","year":"2004","journal-title":"Nat. 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