{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:06:21Z","timestamp":1792735581317,"version":"4.5.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The HIV pandemic disproportionately affects women, with most infections acquired through receptive vaginal sex. Although the target cells by which HIV establishes infection in the female genital tract remain poorly defined, it is known that immune activation results in CD4+ T cells with enhanced susceptibility, as does expression of the mucosal integrin \u03b14\u03b27 and the HIV coreceptor CCR5. Blood and cervical cytobrush specimens were collected from female sex workers (FSWs) in Nairobi, Kenya. Genital infection diagnostics were performed, T cell populations were defined by multiparameter flow cytometry based on their expression of surface receptors relevant to mucosal homing and\/or HIV acquisition, and cytokine production was assayed by intracellular cytokine staining. The integrin \u03b14\u03b27 was expressed on 26.0% of cervical CD4+ T cells, and these cells were more likely to express both the HIV coreceptor CCR5 (p &amp;lt; 0.0001) and the early activation marker CD69 (p &amp;lt; 0.0001) but not CXCR4 (p = 0.34). Cervical Th17 frequencies were enhanced compared with blood (7.02 versus 1.24%; p &amp;lt; 0.0001), and cervical IL-17A+ CD4+ T cells preferentially coexpressed \u03b14\u03b27 and CCR5. Expression of IFN-\u03b3 and IL-22 was greater in cervical Th17 cells than in blood Th17 cells. In keeping with the hypothesis that these cells are preferential HIV targets, gp120 preferentially bound CCR5+ cervical T cells, and cervical Th17 cells were almost completely depleted in HIV+ FSWs compared with HIV\u2212 FSWs. In summary, a subset of Th17 CD4+ T cells in the cervical mucosa coexpresses multiple HIV susceptibility markers; their dramatic depletion after HIV infection suggests that these may serve as key target cells during HIV transmission.<\/jats:p>","DOI":"10.4049\/jimmunol.1101836","type":"journal-article","created":{"date-parts":[[2011,11,3]],"date-time":"2011-11-03T00:52:42Z","timestamp":1320281562000},"page":"6032-6042","source":"Crossref","is-referenced-by-count":167,"title":["Characterization of a Human Cervical CD4+ T Cell Subset Coexpressing Multiple Markers of HIV Susceptibility"],"prefix":"10.1093","volume":"187","author":[{"given":"Lyle R","family":"McKinnon","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Toronto , Toronto, Ontario ,","place":["Canada M5A 1A8"]},{"name":"Department of Medical Microbiology, University of Nairobi , Nairobi ,","place":["Kenya 00202"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Billy","family":"Nyanga","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, University of Nairobi , Nairobi ,","place":["Kenya 00202"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duncan","family":"Chege","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Toronto , Toronto, Ontario ,","place":["Canada M5A 1A8"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preston","family":"Izulla","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, University of Nairobi , Nairobi ,","place":["Kenya 00202"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makobu","family":"Kimani","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, University of Nairobi , Nairobi ,","place":["Kenya 00202"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanja","family":"Huibner","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Toronto , Toronto, Ontario ,","place":["Canada M5A 1A8"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Gelmon","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, University of Nairobi , Nairobi ,","place":["Kenya 00202"]},{"name":"Department of Medical Microbiology, University of Manitoba , Winnipeg, Manitoba ,","place":["Canada R3E 0W3"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharine E","family":"Block","sequence":"additional","affiliation":[{"name":"Laboratory of Immune Regulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Cicala","sequence":"additional","affiliation":[{"name":"Laboratory of Immune Regulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Omu","family":"Anzala","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, University of Nairobi , Nairobi ,","place":["Kenya 00202"]},{"name":"Kenyan AIDS Vaccine Initiative , Nairobi ,","place":["Kenya 00202"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Arthos","sequence":"additional","affiliation":[{"name":"Laboratory of Immune Regulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Kimani","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, University of Nairobi , Nairobi ,","place":["Kenya 00202"]},{"name":"Department of Medical Microbiology, University of Manitoba , Winnipeg, Manitoba ,","place":["Canada R3E 0W3"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupert","family":"Kaul","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Toronto , Toronto, Ontario ,","place":["Canada M5A 1A8"]},{"name":"Department of Medical Microbiology, University of Nairobi , Nairobi ,","place":["Kenya 00202"]},{"name":"Department of Medicine, University Health Network , Toronto, Ontario ,","place":["Canada M5A 1A8"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,12,1]]},"reference":[{"key":"2025032410494248700_r1","article-title":"Joint United Nations Programme on HIV\/AIDS (UNAIDS)","author":"2010. 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