{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:41:47Z","timestamp":1790372507838,"version":"4.1.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>T cell\u2013APC contact initiates T cell activation and is maintained by the integrin LFA-1. Talin1, an LFA-1 regulator, localizes to the immune synapse (IS) with unknown roles in T cell activation. In this study, we show that talin1-deficient T cells have defects in contact-dependent T cell stopping and proliferation. Although talin1-deficient T cells did not form stable interactions with APCs, transient contacts were sufficient to induce signaling. In contrast to prior models, LFA-1 polarized to T cell\u2013APC contacts in talin1-deficient T cells, but vinculin and F-actin polarization at the IS was impaired. These results indicate that T cell proliferation requires sustained, talin1-mediated T cell\u2013APC interactions and that talin1 is necessary for F-actin polarization and the stability of the IS.<\/jats:p>","DOI":"10.4049\/jimmunol.1102028","type":"journal-article","created":{"date-parts":[[2011,11,10]],"date-time":"2011-11-10T06:19:54Z","timestamp":1320905994000},"page":"6256-6267","source":"Crossref","is-referenced-by-count":67,"title":["Contact-Dependent T Cell Activation and T Cell Stopping Require Talin1"],"prefix":"10.1093","volume":"187","author":[{"given":"Sarah A","family":"Wernimont","sequence":"first","affiliation":[{"name":"Program in Cellular and Molecular Biology, University of Wisconsin , Madison, WI 53705"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J","family":"Wiemer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Wisconsin , Madison, WI 53706"},{"name":"Department of Medical Microbiology and Immunology, University of Wisconsin , Madison, WI 53706"},{"name":"Institute on Aging, University of Wisconsin-Madison , Madison, WI 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Bennin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Wisconsin , Madison, WI 53706"},{"name":"Department of Medical Microbiology and Immunology, University of Wisconsin , Madison, WI 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan J","family":"Monkley","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Leicester , Leicester LE1 9HN ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Ludwig","sequence":"additional","affiliation":[{"name":"Institute for Cancer Genetics, Columbia University , New York, NY 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R","family":"Critchley","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Leicester , Leicester LE1 9HN ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Huttenlocher","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Wisconsin , Madison, WI 53706"},{"name":"Department of Medical Microbiology and Immunology, University of Wisconsin , Madison, WI 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,12,15]]},"reference":[{"key":"2025032410515361700_r1","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1146\/annurev.immunol.021908.132706","article-title":"T cell activation","volume":"27","author":"Smith-Garvin","year":"2009","journal-title":"Annu. 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