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They are healthy and fertile and have normal longevity; however, they show certain phenotypic characteristics distinct from wild-type mice, including increased numbers of splenic B, regulatory T, and dendritic cells. As LAIR-1\u2212\/\u2212 mice age, the splenic T cell population shows a higher frequency of activated and memory T cells. Because LAIR-1+\/+ and LAIR-1\u2212\/\u2212 T cells traffic with equal proficiency to peripheral lymphoid organs, this is not likely due to abnormal T lymphocyte trafficking. LAIR-1\u2212\/\u2212 mice have lower serum levels of IgG1 and, in response to T-dependent immunization with trinitrophenyl-OVA, switch less efficiently to Ag specific IgG2a and IgG2b, whereas switching to IgG1 is not affected. Several mouse disease models, including experimental autoimmune encephalitis and colitis, were used to examine the effect of LAIR-1 deficiency, and no differences in the responses of LAIR-1\u2212\/\u2212 and LAIR-1+\/+ mice were observed. Taken together, these observations indicate that LAIR-1 plays a role in regulating immune cells and suggest that any adverse effects of its absence may be balanced in vivo by other inhibitory receptors.<\/jats:p>","DOI":"10.4049\/jimmunol.1102044","type":"journal-article","created":{"date-parts":[[2011,12,8]],"date-time":"2011-12-08T03:03:05Z","timestamp":1323313385000},"page":"548-558","source":"Crossref","is-referenced-by-count":51,"title":["Leukocyte-Associated Ig-like Receptor-1\u2013Deficient Mice Have an Altered Immune Cell Phenotype"],"prefix":"10.1093","volume":"188","author":[{"given":"Xiaobin","family":"Tang","sequence":"first","affiliation":[{"name":"Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Rockville, MD 20852"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linjie","family":"Tian","sequence":"additional","affiliation":[{"name":"Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Rockville, MD 20852"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria","family":"Esteso","sequence":"additional","affiliation":[{"name":"Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Rockville, MD 20852"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Chul","family":"Choi","sequence":"additional","affiliation":[{"name":"Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Rockville, MD 20852"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander D","family":"Barrow","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, MO 63110"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Colonna","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, MO 63110"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Borrego","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Developmental Immunology, Division of Monoclonal Antibodies, Center for Drug Evaluation and Research, Food and Drug Administration , Bethesda, MD 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John E","family":"Coligan","sequence":"additional","affiliation":[{"name":"Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Rockville, MD 20852"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,1,15]]},"reference":[{"key":"2025032409445520600_r1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1600-065X.2008.00660.x","article-title":"Negative signaling by inhibitory receptors: the NK cell paradigm","volume":"224","author":"Long","year":"2008","journal-title":"Immunol. 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