{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:29:41Z","timestamp":1791192581484,"version":"4.1.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Although c-myc is classically described as the driving oncogene in Burkitt\u2019s lymphoma (BL), deregulation and mutations of c-myc have been reported in multiple solid tumors and in other mature B cell malignancies such as mantle cell lymphoma (MCL), myeloma, and plasma cell lymphoma (PCL). After translocation into the IgH locus, c-myc is constitutively expressed under the control of active IgH enhancers. Those located in the IgH 3\u2032 regulatory region (3\u2032RR) are master control elements of class switch recombination and of the transcriptional burst associated with plasma cell differentiation. c-myc-3\u2032RR mice are prone to lymphomas with rather homogeneous, most often BL-like, phenotypes with incomplete penetrance (75% tumor incidence) and long latencies (10\u201312 mo). To reproduce c-myc\u2013induced mature B cell lymphomagenesis in the context of an additional defect often observed in human lymphomas, we intercrossed c-myc-3\u2032RR with p53+\/\u2212 mice. Double transgenic c-myc-3\u2032RR\/p53+\/\u2212 mice developed lymphoma with short latency (2\u20134 mo) and full penetrance (100% tumor incidence). The spectrum of B lymphomas occurring in c-myc-3\u2032RR\/p53+\/\u2212 mice was widened, including nonactivated (CD43\u2212) BL, activated (CD43+) BL, MCL-like lymphoma, and PCL, thus showing that 3\u2032RR-mediated deregulation of c-myc can promote various types of B lymphoproliferation in cells that first acquired a p53 defect. c-myc\/p53+\/\u2212 mice closely reproduce many features of BL, MCL, and PCL and provide a novel and efficient model to dissect the molecular events leading to c-myc\u2013induced lymphomagenesis and an important tool to test potential therapeutic agents on malignant B cells featuring various maturation stages.<\/jats:p>","DOI":"10.4049\/jimmunol.1102059","type":"journal-article","created":{"date-parts":[[2011,10,29]],"date-time":"2011-10-29T03:46:49Z","timestamp":1319860009000},"page":"5772-5782","source":"Crossref","is-referenced-by-count":18,"title":["A p53 Defect Sensitizes Various Stages of B Cell Development to Lymphomagenesis in Mice Carrying an IgH 3\u2032 Regulatory Region-Driven c-<i>myc<\/i> Transgene"],"prefix":"10.1093","volume":"187","author":[{"given":"R\u00e9mi","family":"Fiancette","sequence":"first","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, Unit\u00e9 Mixte de Recherche 6101, Centre National de la Recherche Scientifique , 87025 Limoges ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Rouaud","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, Unit\u00e9 Mixte de Recherche 6101, Centre National de la Recherche Scientifique , 87025 Limoges ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Vincent-Fabert","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, Unit\u00e9 Mixte de Recherche 6101, Centre National de la Recherche Scientifique , 87025 Limoges ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brice","family":"Laffleur","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, Unit\u00e9 Mixte de Recherche 6101, Centre National de la Recherche Scientifique , 87025 Limoges ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Magnone","sequence":"additional","affiliation":[{"name":"Institut de Pharmacologie Mol\u00e9culaire et Cellulaire, Unit\u00e9 Mixte de Recherche 6097, Centre National de la Recherche Scientifique and Universit\u00e9 de Nice Sophia Antipolis , 06560 Sophia Antipolis ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Cogn\u00e9","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, Unit\u00e9 Mixte de Recherche 6101, Centre National de la Recherche Scientifique , 87025 Limoges ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Denizot","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, Unit\u00e9 Mixte de Recherche 6101, Centre National de la Recherche Scientifique , 87025 Limoges ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,12,1]]},"reference":[{"key":"2025032410511514300_r1","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nrc2230","article-title":"Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics","volume":"7","author":"Jares","year":"2007","journal-title":"Nat. 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Immunol."},{"key":"2025032410511514300_r5","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1002\/eji.201040778","article-title":"The IgH 3\u2032 regulatory region and its implication in lymphomagenesis","volume":"40","author":"Vincent-Fabert","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"2025032410511514300_r6","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/318533a0","article-title":"The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice","volume":"318","author":"Adams","year":"1985","journal-title":"Nature"},{"key":"2025032410511514300_r7","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1182\/blood-2010-01-264689","article-title":"Genomic deletion of the whole IgH 3\u2032 regulatory region (hs3a, hs1,2, hs3b, and hs4) dramatically affects class switch recombination and Ig secretion to all isotypes","volume":"116","author":"Vincent-Fabert","year":"2010","journal-title":"Blood"},{"key":"2025032410511514300_r8","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nature08633","article-title":"Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3\u2032 regulatory region","volume":"462","author":"Gostissa","year":"2009","journal-title":"Nature"},{"key":"2025032410511514300_r9","doi-asserted-by":"crossref","first-page":"6033","DOI":"10.4049\/jimmunol.179.9.6033","article-title":"The 3\u2032 IgH locus control region is sufficient to deregulate a c-myc transgene and promote mature B cell malignancies with a predominant Burkitt-like phenotype","volume":"179","author":"Truffinet","year":"2007","journal-title":"J. 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