{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:51:49Z","timestamp":1791291109888,"version":"4.3.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>RANKL\u2013RANK signaling regulates numerous physiologic processes such as bone remodeling, lymph node organogenesis, central thermoregulation, and formation of a lactating mammary gland in pregnancy. Recently, a receptor activator of NF-\u03baB ligand (RANKL)-blocking Ab has been approved for human use in potentially millions of osteoporosis and cancer patients. However, germline deficiencies in RANKL or receptor activator of NF-\u03baB (RANK) also lead to strong B cell defects in mice and human patients, suggesting that RANKL\u2013RANK inhibition could interfere with B cell physiology and thereby trigger immunologic side-effects. To address this key question\u2014that is, whether RANKL\u2013RANK signaling affects B cell physiology directly or the observed defects are secondary because of the severe osteopetrosis\u2014we generated B cell-specific RANK knockout mice. We show that B cells deficient for RANK undergo normal development and do not show any obvious defects in Ab secretion, class switch recombination, or somatic hypermutation. Our data indicate that ablation of the RANKL\u2013RANK pathway has no direct adverse effect on B cell physiology.<\/jats:p>","DOI":"10.4049\/jimmunol.1102063","type":"journal-article","created":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T00:54:49Z","timestamp":1325811289000},"page":"1201-1205","source":"Crossref","is-referenced-by-count":57,"title":["Development and Function of Murine B Cells Lacking RANK"],"prefix":"10.1093","volume":"188","author":[{"given":"Thomas","family":"Perlot","sequence":"first","affiliation":[{"name":"Institute of Molecular Biotechnology of the Austrian Academy of Sciences , 1030 Vienna ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef M","family":"Penninger","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biotechnology of the Austrian Academy of Sciences , 1030 Vienna ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,2,1]]},"reference":[{"key":"2025032409500412200_r1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1196\/annals.1443.016","article-title":"RANK\/RANKL: regulators of immune responses and bone physiology","volume":"1143","author":"Leibbrandt","year":"2008","journal-title":"Ann. 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