{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:33:02Z","timestamp":1791387182510,"version":"4.3.3"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Age-related adiposity has been linked to chronic inflammatory diseases in late life. To date, the studies on adipose tissue leukocytes and aging have not taken into account the heterogeneity of adipose tissue macrophages (ATMs), nor have they examined how age impacts other leukocytes such as T cells in fat. Therefore, we have performed a detailed examination of ATM subtypes in young and old mice using state of the art techniques. Our results demonstrate qualitative changes in ATMs with aging that generate a decrease in resident type 2 (M2) ATMs. The profile of ATMs in old fat shifts toward a proinflammatory environment with increased numbers of CD206\u2212CD11c\u2212 (double-negative) ATMs. The mechanism of this aging-induced shift in the phenotypic profile of ATMs was found to be related to a decrease in peroxisome proliferator-activated receptor-\u03b3 expression in ATMs and alterations in chemokine\/chemokine receptor expression profiles. Furthermore, we have revealed a profound and unexpected expansion of adipose tissue T cells in visceral fat with aging that includes a significant induction of regulatory T cells in fat. Our findings demonstrate a unique inflammatory cell signature in the physiologic context of aging adipose tissue that differs from those induced in setting of diet-induced obesity.<\/jats:p>","DOI":"10.4049\/jimmunol.1102188","type":"journal-article","created":{"date-parts":[[2011,11,10]],"date-time":"2011-11-10T01:19:54Z","timestamp":1320887994000},"page":"6208-6216","source":"Crossref","is-referenced-by-count":313,"title":["Aging Is Associated with an Increase in T Cells and Inflammatory Macrophages in Visceral Adipose Tissue"],"prefix":"10.1093","volume":"187","author":[{"given":"Carey N","family":"Lumeng","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Communicable Diseases, University of Michigan , Ann Arbor, MI 48109"},{"name":"Department of Molecular and Integrative Physiology, University of Michigan , Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan , Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Geletka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Communicable Diseases, University of Michigan , Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Delaney","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan , Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Delproposto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Communicable Diseases, University of Michigan , Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan , Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsie","family":"Oatmen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Communicable Diseases, University of Michigan , Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Martinez-Santibanez","sequence":"additional","affiliation":[{"name":"Graduate Program in Cellular and Molecular Biology, University of Michigan , Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabelle","family":"Julius","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan , Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan , Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond L","family":"Yung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan , Ann Arbor, MI 48109"},{"name":"Geriatric Research, Education, and Clinical Center, Veterans Affairs Ann Arbor Healthcare System , Ann Arbor, MI 48105"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,12,15]]},"reference":[{"key":"2025032410534209800_r1","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1189\/jlb.0809542","article-title":"Leukocyte function in the aging immune system","volume":"87","author":"Desai","year":"2010","journal-title":"J. Leukoc. Biol."},{"key":"2025032410534209800_r2","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1111\/j.1532-5415.2008.01673.x","article-title":"T-lymphocytes expressing CC chemokine receptor-5 are increased in frail older adults","volume":"56","author":"De Fanis","year":"2008","journal-title":"J. Am. Geriatr. Soc."},{"key":"2025032410534209800_r3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/BF03327392","article-title":"Decreased cell proliferation and altered cytokine production in frail older adults","volume":"16","author":"Leng","year":"2004","journal-title":"Aging Clin. Exp. Res."},{"key":"2025032410534209800_r4","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/gerona\/63.4.391","article-title":"The physical and biological characterization of a frail mouse model","volume":"63","author":"Walston","year":"2008","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"2025032410534209800_r5","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/S0899-9007(97)00031-2","article-title":"Effect of sex and age on bone mass, body composition and fuel metabolism in humans","volume":"13","author":"Horber","year":"1997","journal-title":"Nutrition"},{"key":"2025032410534209800_r6","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0531-5565(94)90018-3","article-title":"Menopausal changes in body composition and energy expenditure","volume":"29","author":"Heymsfield","year":"1994","journal-title":"Exp. Gerontol."},{"key":"2025032410534209800_r7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/ajcn\/66.1.111","article-title":"Effects of age on body fat distribution and cardiovascular risk factors in women","volume":"66","author":"Zamboni","year":"1997","journal-title":"Am. J. Clin. Nutr."},{"key":"2025032410534209800_r8","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.2337\/diacare.22.9.1471","article-title":"Age-related increase in visceral adipose tissue and body fat and the metabolic risk profile of premenopausal women","volume":"22","author":"Pascot","year":"1999","journal-title":"Diabetes Care"},{"key":"2025032410534209800_r9","doi-asserted-by":"crossref","first-page":"e1000752","DOI":"10.1371\/journal.pgen.1000752","article-title":"Ppargamma2 is a key driver of longevity in the mouse","volume":"5","author":"Argmann","year":"2009","journal-title":"PLoS Genet."},{"key":"2025032410534209800_r10","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1080\/01926230490515283","article-title":"Decreased longevity and enhancement of age-dependent lesions in mice lacking the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha)","volume":"32","author":"Howroyd","year":"2004","journal-title":"Toxicol. Pathol."},{"key":"2025032410534209800_r11","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1038\/sj.ijo.0802912","article-title":"Molecular links between aging and adipose tissue","volume":"29","author":"Picard","year":"2005","journal-title":"Int. J. Obes."},{"key":"2025032410534209800_r12","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1146\/annurev-immunol-031210-101322","article-title":"Inflammatory mechanisms in obesity","volume":"29","author":"Gregor","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"2025032410534209800_r13","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1172\/JCI57132","article-title":"Inflammatory links between obesity and metabolic disease","volume":"121","author":"Lumeng","year":"2011","journal-title":"J. Clin. Invest."},{"key":"2025032410534209800_r14","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/nm0809-846","article-title":"T-ing up inflammation in fat","volume":"15","author":"Lumeng","year":"2009","journal-title":"Nat. Med."},{"key":"2025032410534209800_r15","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature05485","article-title":"Inflammation and metabolic disorders","volume":"444","author":"Hotamisligil","year":"2006","journal-title":"Nature"},{"key":"2025032410534209800_r16","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/nm.1994","article-title":"Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice","volume":"15","author":"Liu","year":"2009","journal-title":"Nat. Med."},{"key":"2025032410534209800_r17","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/nm.2353","article-title":"B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies","volume":"17","author":"Winer","year":"2011","journal-title":"Nat. Med."},{"key":"2025032410534209800_r18","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev-physiol-021909-135846","article-title":"Macrophages, inflammation, and insulin resistance","volume":"72","author":"Olefsky","year":"2010","journal-title":"Annu. Rev. Physiol."},{"key":"2025032410534209800_r19","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1749-6632.2000.tb06651.x","article-title":"Inflamm-aging: an evolutionary perspective on immunosenescence","volume":"908","author":"Franceschi","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2025032410534209800_r20","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.2174\/138161206777947470","article-title":"Inflamm-aging, cytokines and aging: state of the art, new hypotheses on the role of mitochondria and new perspectives from systems biology","volume":"12","author":"Salvioli","year":"2006","journal-title":"Curr. Pharm. Des."},{"key":"2025032410534209800_r21","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.2337\/db09-1402","article-title":"Dynamic, M2-like remodeling phenotypes of CD11c+ adipose tissue macrophages during high-fat diet-induced obesity in mice","volume":"59","author":"Shaul","year":"2010","journal-title":"Diabetes"},{"key":"2025032410534209800_r22","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.2337\/db09-0287","article-title":"Pro-inflammatory CD11c+CD206+ adipose tissue macrophages are associated with insulin resistance in human obesity","volume":"59","author":"Wentworth","year":"2010","journal-title":"Diabetes"},{"key":"2025032410534209800_r23","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1172\/JCI29881","article-title":"Obesity induces a phenotypic switch in adipose tissue macrophage polarization","volume":"117","author":"Lumeng","year":"2007","journal-title":"J. Clin. Invest."},{"key":"2025032410534209800_r24","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1084\/jem.20091333","article-title":"MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7\/4hi monocytes in obesity","volume":"206","author":"Westcott","year":"2009","journal-title":"J. Exp. Med."},{"key":"2025032410534209800_r25","doi-asserted-by":"crossref","first-page":"22617","DOI":"10.1073\/pnas.1009152108","article-title":"IL-4\/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity","volume":"107","author":"Ricardo-Gonzalez","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032410534209800_r26","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/nature05894","article-title":"Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance","volume":"447","author":"Odegaard","year":"2007","journal-title":"Nature"},{"key":"2025032410534209800_r27","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.cmet.2008.04.003","article-title":"Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance","volume":"7","author":"Odegaard","year":"2008","journal-title":"Cell Metab."},{"key":"2025032410534209800_r28","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.cmet.2008.04.002","article-title":"Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity","volume":"7","author":"Kang","year":"2008","journal-title":"Cell Metab."},{"key":"2025032410534209800_r29","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1194\/jlr.M500294-JLR200","article-title":"Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans","volume":"46","author":"Cinti","year":"2005","journal-title":"J. Lipid Res."},{"key":"2025032410534209800_r30","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.2337\/db08-0872","article-title":"Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes","volume":"57","author":"Lumeng","year":"2008","journal-title":"Diabetes"},{"key":"2025032410534209800_r31","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1172\/JCI28898","article-title":"TLR4 links innate immunity and fatty acid-induced insulin resistance","volume":"116","author":"Shi","year":"2006","journal-title":"J. Clin. Invest."},{"key":"2025032410534209800_r32","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.cmet.2009.09.006","article-title":"Hematopoietic cell-specific deletion of Toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice","volume":"10","author":"Saberi","year":"2009","journal-title":"Cell Metab."},{"key":"2025032410534209800_r33","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1038\/ijo.2010.103","article-title":"Newly identified adipose tissue macrophage populations in obesity with distinct chemokine and chemokine receptor expression","volume":"34","author":"Zeyda","year":"2010","journal-title":"Int. J. Obes."},{"key":"2025032410534209800_r34","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1161\/ATVBAHA.109.198044","article-title":"CD11c expression in adipose tissue and blood and its role in diet-induced obesity","volume":"30","author":"Wu","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2025032410534209800_r35","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1126\/science.1201475","article-title":"Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis","volume":"332","author":"Wu","year":"2011","journal-title":"Science"},{"key":"2025032410534209800_r36","doi-asserted-by":"crossref","first-page":"4619","DOI":"10.1210\/jc.2009-0925","article-title":"Human adipose tissue macrophages: m1 and m2 cell surface markers in subcutaneous and omental depots and after weight loss","volume":"94","author":"Aron-Wisnewsky","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2025032410534209800_r37","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2337\/db08-0536","article-title":"Macrophage content in subcutaneous adipose tissue: associations with adiposity, age, inflammatory markers, and whole-body insulin action in healthy Pima Indians","volume":"58","author":"Ortega Martinez de Victoria","year":"2009","journal-title":"Diabetes"},{"key":"2025032410534209800_r38","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1016\/j.metabol.2009.04.025","article-title":"Age-related differences in inflammatory markers in men: contribution of visceral adiposity","volume":"58","author":"Cartier","year":"2009","journal-title":"Metabolism"},{"key":"2025032410534209800_r39","doi-asserted-by":"crossref","first-page":"S179","DOI":"10.1016\/j.jaci.2006.12.066","article-title":"Macrophages accumulation in visceral and subcutaneous adipose tissue correlates with age","volume":"119","author":"Jerschow","year":"2007","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025032410534209800_r40","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1093\/gerona\/glq078","article-title":"Aging per se increases the susceptibility to free fatty acid-induced insulin resistance","volume":"65A","author":"Einstein","year":"2010","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"2025032410534209800_r41","doi-asserted-by":"crossref","first-page":"4829","DOI":"10.4049\/jimmunol.179.7.4829","article-title":"Aging up-regulates expression of inflammatory mediators in mouse adipose tissue","volume":"179","author":"Wu","year":"2007","journal-title":"J. Immunol."},{"key":"2025032410534209800_r42","first-page":"365","article-title":"Primer3 on the WWW for general users and for biologist programmers","volume":"132","author":"Rozen","year":"2000","journal-title":"Methods Mol. Biol."},{"key":"2025032410534209800_r43","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1172\/JCI24335","article-title":"CCR2 modulates inflammatory and metabolic effects of high-fat feeding","volume":"116","author":"Weisberg","year":"2006","journal-title":"J. Clin. Invest."},{"key":"2025032410534209800_r44","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1172\/JCI26498","article-title":"MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity","volume":"116","author":"Kanda","year":"2006","journal-title":"J. Clin. Invest."},{"key":"2025032410534209800_r45","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.2337\/db10-0956","article-title":"Fractalkine is a novel human adipochemokine associated with type 2 diabetes","volume":"60","author":"Shah","year":"2011","journal-title":"Diabetes"},{"key":"2025032410534209800_r46","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1172\/JCI29919","article-title":"Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites","volume":"117","author":"Tsou","year":"2007","journal-title":"J. Clin. Invest."},{"key":"2025032410534209800_r47","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.cmet.2007.06.010","article-title":"PPARgamma activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties","volume":"6","author":"Bouhlel","year":"2007","journal-title":"Cell Metab."},{"key":"2025032410534209800_r48","doi-asserted-by":"crossref","first-page":"B997","DOI":"10.1093\/gerona\/59.10.B997","article-title":"Modulation of PPAR in aging, inflammation, and calorie restriction","volume":"59","author":"Sung","year":"2004","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"2025032410534209800_r49","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1073\/pnas.0503839103","article-title":"Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma","volume":"103","author":"Sastre","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032410534209800_r50","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1007\/s11064-005-8341-y","article-title":"PPAR-alpha expression inversely correlates with inflammatory cytokines IL-1beta and TNF-alpha in aging rats","volume":"30","author":"Gelinas","year":"2005","journal-title":"Neurochem. Res."},{"key":"2025032410534209800_r51","doi-asserted-by":"crossref","first-page":"22620","DOI":"10.1074\/jbc.M710314200","article-title":"Peroxisome proliferator-activated receptor gamma activation promotes infiltration of alternatively activated macrophages into adipose tissue","volume":"283","author":"Stienstra","year":"2008","journal-title":"J. Biol. Chem."},{"key":"2025032410534209800_r52","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nature08636","article-title":"Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells","volume":"463","author":"Moro","year":"2010","journal-title":"Nature"},{"key":"2025032410534209800_r53","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/MCO.0b013e328347970b","article-title":"Adipose tissue macrophages: phenotypic plasticity and diversity in lean and obese states","volume":"14","author":"Morris","year":"2011","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"2025032410534209800_r54","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/nm.1964","article-title":"CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity","volume":"15","author":"Nishimura","year":"2009","journal-title":"Nat. Med."},{"key":"2025032410534209800_r55","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/nm.2001","article-title":"Normalization of obesity-associated insulin resistance through immunotherapy","volume":"15","author":"Winer","year":"2009","journal-title":"Nat. Med."},{"key":"2025032410534209800_r56","doi-asserted-by":"crossref","first-page":"e16376","DOI":"10.1371\/journal.pone.0016376","article-title":"Visceral adipose inflammation in obesity is associated with critical alterations in T regulatory cell numbers","volume":"6","author":"Deiuliis","year":"2011","journal-title":"PLoS One"},{"key":"2025032410534209800_r57","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/nm.2002","article-title":"Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters","volume":"15","author":"Feuerer","year":"2009","journal-title":"Nat. Med."},{"key":"2025032410534209800_r58","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.mad.2009.06.003","article-title":"Aging and human CD4(+) regulatory T cells","volume":"130","author":"Hwang","year":"2009","journal-title":"Mech. Ageing Dev."},{"key":"2025032410534209800_r59","doi-asserted-by":"crossref","first-page":"8348","DOI":"10.4049\/jimmunol.177.12.8348","article-title":"High accumulation of T regulatory cells prevents the activation of immune responses in aged animals","volume":"177","author":"Sharma","year":"2006","journal-title":"J. Immunol."},{"key":"2025032410534209800_r60","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1189\/jlb.0506364","article-title":"Changes of CD4+CD25+Foxp3+ regulatory T cells in aged BALB\/c mice","volume":"81","author":"Zhao","year":"2007","journal-title":"J. Leukoc. Biol."},{"key":"2025032410534209800_r61","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.immuni.2009.03.014","article-title":"Omental milky spots develop in the absence of lymphoid tissue-inducer cells and support B and T cell responses to peritoneal antigens","volume":"30","author":"Rangel-Moreno","year":"2009","journal-title":"Immunity"},{"key":"2025032410534209800_r62","doi-asserted-by":"crossref","first-page":"3466","DOI":"10.1172\/JCI42845","article-title":"Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue","volume":"120","author":"Kosteli","year":"2010","journal-title":"J. Clin. Invest."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/187\/12\/6208\/61606017\/1102188.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/187\/12\/6208\/61606017\/1102188.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T03:16:57Z","timestamp":1743131817000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/187\/12\/6208\/7977281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":62,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1102188","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717949620.793454826","asserted-by":"object"}]},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2011,12]]},"published":{"date-parts":[[2011,12]]}}}