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B7-H1, also called PD-L1, is a cosignaling molecule of the B7 family that can inhibit activated T cell effectors by interaction with its receptor PD-1. In this work, we have studied the dependence of B7-H1 on NF-\u03baB and c-Myc, the two main transcription factors in EBV latency III proliferating B cells, on various lymphoblastoid and Burkitt lymphoma cell lines, some of them being inducible or not for the EBV latency III program and\/or for c-Myc. We found that B7-H1 repressed killing of EBV-immortalized B cells by their autologous T and NK cells. At the mRNA level, NF-\u03baB was a weak inducer whereas c-Myc was a strong repressor of B7-H1 expression, an effect mediated by STAT1 inhibition. At the protein level, B7-H1 molecules were stored in both degradative and unconventional secretory lysosomes. Surface membrane B7-H1 molecules were constitutively internalized and proteolyzed in lysosomes. The EBV latency III program increased the amounts of B7-H1\u2013containing secretory lysosomes and their export to the surface membrane. By repressing actin polymerization, c-Myc blocked secretory lysosome migration and B7-H1 surface membrane export. In addition to B7-H1, various immunoregulatory molecules participating in the immunological synapse are stored in secretory lysosomes. By playing on actin polymerization, c-Myc could thus globally regulate the immunogenicity of transformed B cells, acting on export of secretory lysosomes to plasma membrane.<\/jats:p>","DOI":"10.4049\/jimmunol.1102277","type":"journal-article","created":{"date-parts":[[2012,6,2]],"date-time":"2012-06-02T05:23:17Z","timestamp":1338614597000},"page":"181-190","source":"Crossref","is-referenced-by-count":40,"title":["B7-H1, Which Represses EBV-Immortalized B Cell Killing by Autologous T and NK Cells, Is Oppositely Regulated by c-Myc and EBV Latency III Program at Both mRNA and Secretory Lysosome Levels"],"prefix":"10.1093","volume":"189","author":[{"given":"St\u00e9phanie","family":"Durand-Panteix","sequence":"first","affiliation":[{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche CNRS 7276, Facult\u00e9 de M\u00e9decine , 87025 Limoges Cedex,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Farhat","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche CNRS 7276, Facult\u00e9 de M\u00e9decine , 87025 Limoges Cedex,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibtissam","family":"Youlyouz-Marfak","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche CNRS 7276, Facult\u00e9 de M\u00e9decine , 87025 Limoges Cedex,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Rouaud","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche CNRS 7276, Facult\u00e9 de M\u00e9decine , 87025 Limoges Cedex,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Ouk-Martin","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche CNRS 7276, Facult\u00e9 de M\u00e9decine , 87025 Limoges Cedex,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandine","family":"David","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche CNRS 7276, Facult\u00e9 de M\u00e9decine , 87025 Limoges Cedex,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Faumont","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche CNRS 7276, Facult\u00e9 de M\u00e9decine , 87025 Limoges Cedex,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Feuillard","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche CNRS 7276, Facult\u00e9 de M\u00e9decine , 87025 Limoges Cedex,","place":["France"]},{"name":"Centre Hospitalier Universitaire Dupuytren, Laboratoire d\u2019H\u00e9matologie , 87042 Limoges Cedex,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Jayat-Vignoles","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche CNRS 7276, Facult\u00e9 de M\u00e9decine , 87025 Limoges Cedex,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,7,1]]},"reference":[{"key":"2025032409155685100_r1","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1136\/mp.53.5.238","article-title":"The expression and function of Epstein-Barr virus encoded latent genes","volume":"53","author":"Young","year":"2000","journal-title":"MP, Mol. 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Biochem."},{"key":"2025032409155685100_r39","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1016\/j.yexcr.2008.09.020","article-title":"Trafficking and function of the tetraspanin CD63","volume":"315","author":"Pols","year":"2009","journal-title":"Exp. Cell Res."},{"key":"2025032409155685100_r40","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0167-4889(03)00087-9","article-title":"Actin remodeling to facilitate membrane fusion","volume":"1641","author":"Eitzen","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"2025032409155685100_r41","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.ceb.2007.04.017","article-title":"Actin in membrane trafficking","volume":"19","author":"Lanzetti","year":"2007","journal-title":"Curr. Opin. 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