{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:50:37Z","timestamp":1791125437745,"version":"4.1.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Follicular dendritic cells (FDCs) protect germinal center (GC) B cells from rapid apoptosis to allow their survival and maturation. In this article, we show that FDCs normally produce and secrete Wnt5a to protect GC B cells. Wnt5a production is upregulated by polyI:C. Purified Wnt5a protects GC B cells from apoptosis in a dose-dependent manner. GC B cells are protected by FDC coculture or conditioned medium, and the protection is inhibited significantly by anti-Wnt5a Ab, suggesting a major role of Wnt5a in the FDC-mediated GC B cell protection. A calcium chelator BAPTA-AM blocks the Wnt5a-mediated GC B cell protection, implying a role of Wnt\/Ca2+ signaling in the GC B cell survival. Wnt5a and calcium ionophore activate NFATc1, NFATc2, NF-\u03baB, and B cell lymphoma 6 (BCL-6) promptly and upregulate CD40 expression in GC B and Ramos cells, whereas p53 and JNK are not upregulated or activated. Cyclosporine A inhibits the Wnt5a and calcium-induced activation of NF-\u03baB and BCL-6 in Ramos cells, supporting a role of \u03b2-catenin\u2013independent Wnt\/Ca2+\/NFAT\/NF-\u03baB\u2013BCL-6 signaling. Our data support that Wnt5a is a novel survival factor for GC B cells and might be a potential target for the regulation of B cell immunity.<\/jats:p>","DOI":"10.4049\/jimmunol.1102297","type":"journal-article","created":{"date-parts":[[2011,11,30]],"date-time":"2011-11-30T02:45:08Z","timestamp":1322621108000},"page":"182-189","source":"Crossref","is-referenced-by-count":66,"title":["Wnt5a Is Secreted by Follicular Dendritic Cells To Protect Germinal Center B Cells via Wnt\/Ca2+\/NFAT\/NF-\u03baB\u2013B Cell Lymphoma 6 Signaling"],"prefix":"10.1093","volume":"188","author":[{"given":"Jungtae","family":"Kim","sequence":"first","affiliation":[{"name":"Asan Medical Center, Asan Institute for Life Sciences, University of Ulsan College of Medicine , Seoul 138-736 ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Asan Medical Center, Asan Institute for Life Sciences, University of Ulsan College of Medicine , Seoul 138-736 ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wookyoung","family":"Chang","sequence":"additional","affiliation":[{"name":"Asan Medical Center, Asan Institute for Life Sciences, University of Ulsan College of Medicine , Seoul 138-736 ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jongseon","family":"Choe","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Kangwon National University College of Medicine , Chunchon, Kangwon 200-701 ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine , Seoul 138-736 ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan-Sik","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine , Seoul 138-736 ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyuyoung","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Asan Medical Center, University of Ulsan College of Medicine , Seoul 138-736 ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inchul","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine , Seoul 138-736 ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,1,1]]},"reference":[{"key":"2025032409441495200_r1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nri2217","article-title":"Germinal centres: role in B-cell physiology and malignancy","volume":"8","author":"Klein","year":"2008","journal-title":"Nat. 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