{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:20:37Z","timestamp":1790868037477,"version":"4.1.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We studied whether CD8 T cell responses that are mediated by unconventional MHC class Ib molecules are IL-15 dependent in mice. CD8+ T cell responses to Listeria monocytogenes infection that are restricted by the MHC class Ib molecule H2-M3 decreased in the absence of IL-15, whereas other primary MHC class Ib- and MHC class Ia-restricted responses were IL-15 independent. This result was confirmed in MHC class Ia-deficient mice in which IL-15 deficiency also reduced H2-M3\u2013restricted but not all CD8 T cell responses to L. monocytogenes. IL-15 deficiency did not affect proliferation or survival of responding H2-M3\u2013restricted CD8+ T cells, but IL-15 was necessary to detect H2-M3\u2013restricted CD8+ T cells in naive mice. This finding suggests that these CD8+ T cells require IL-15 during development, but become IL-15 independent after activation. IL-15 was necessary for the survival of most class Ib-restricted CD8+ T cells, starting at the mature thymocyte stage in naive mice, but does not affect a distinct CD44low\/CD122low subpopulation. These data suggest that the nature of the selecting MHC class Ib molecule determines whether CD8+ T cells acquire IL-15 dependence during thymic development.<\/jats:p>","DOI":"10.4049\/jimmunol.1102393","type":"journal-article","created":{"date-parts":[[2012,2,7]],"date-time":"2012-02-07T08:15:09Z","timestamp":1328602509000},"page":"2575-2582","source":"Crossref","is-referenced-by-count":3,"title":["Selective Dependence of H2-M3\u2013Restricted CD8 Responses on IL-15"],"prefix":"10.1093","volume":"188","author":[{"given":"J\u00fcrgen R","family":"M\u00fcller","sequence":"first","affiliation":[{"name":"Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A","family":"Waldmann","sequence":"additional","affiliation":[{"name":"Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrid","family":"Dubois","sequence":"additional","affiliation":[{"name":"Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,3,15]]},"reference":[{"key":"2025032409591259700_r1","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.molmed.2003.10.005","article-title":"IL-15 in the life and death of lymphocytes: immunotherapeutic implications","volume":"9","author":"Waldmann","year":"2003","journal-title":"Trends Mol. Med."},{"key":"2025032409591259700_r2","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S1074-7613(00)80664-0","article-title":"IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation","volume":"9","author":"Lodolce","year":"1998","journal-title":"Immunity"},{"key":"2025032409591259700_r3","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0065-2776(04)86006-1","article-title":"Interleukin-2, interleukin-15, and their roles in human natural killer cells","volume":"86","author":"Becknell","year":"2005","journal-title":"Adv. Immunol."},{"key":"2025032409591259700_r4","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S1074-7613(02)00429-6","article-title":"IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells","volume":"17","author":"Dubois","year":"2002","journal-title":"Immunity"},{"key":"2025032409591259700_r5","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/nm1615","article-title":"IL-15 constrains mast cell-dependent antibacterial defenses by suppressing chymase activities","volume":"13","author":"Orinska","year":"2007","journal-title":"Nat. Med."},{"key":"2025032409591259700_r6","doi-asserted-by":"crossref","first-page":"8662","DOI":"10.1073\/pnas.0503360102","article-title":"Survival adjustment of mature dendritic cells by IL-15","volume":"102","author":"Dubois","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032409591259700_r7","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1084\/jem.20020369","article-title":"Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells","volume":"195","author":"Becker","year":"2002","journal-title":"J. Exp. Med."},{"key":"2025032409591259700_r8","doi-asserted-by":"crossref","first-page":"4827","DOI":"10.4049\/jimmunol.168.10.4827","article-title":"Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells","volume":"168","author":"Schluns","year":"2002","journal-title":"J. Immunol."},{"key":"2025032409591259700_r9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S1465-3249(05)70786-6","article-title":"IL-15: targeting CD8+ T cells for immunotherapy","volume":"7","author":"Diab","year":"2005","journal-title":"Cytotherapy"},{"key":"2025032409591259700_r10","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.4049\/jimmunol.178.6.3492","article-title":"Interleukin-15 but not interleukin-7 abrogates vaccine-induced decrease in virus level in simian immunodeficiency virus mac251-infected macaques","volume":"178","author":"Hryniewicz","year":"2007","journal-title":"J. Immunol."},{"key":"2025032409591259700_r11","doi-asserted-by":"crossref","first-page":"350","DOI":"10.4049\/jimmunol.180.1.350","article-title":"IL-15 treatment during acute simian immunodeficiency virus (SIV) infection increases viral set point and accelerates disease progression despite the induction of stronger SIV-specific CD8+ T cell responses","volume":"180","author":"Mueller","year":"2008","journal-title":"J. Immunol."},{"key":"2025032409591259700_r12","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/nri1461","article-title":"Immune responses to Listeria monocytogenes","volume":"4","author":"Pamer","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"2025032409591259700_r13","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nri1635","article-title":"MHC class Ib molecules bridge innate and acquired immunity","volume":"5","author":"Rodgers","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"2025032409591259700_r14","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.it.2006.07.006","article-title":"A structural perspective on MHC class Ib molecules in adaptive immunity","volume":"27","author":"Sullivan","year":"2006","journal-title":"Trends Immunol."},{"key":"2025032409591259700_r15","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/ni814","article-title":"Positive selection of MHC class Ib-restricted CD8(+) T cells on hematopoietic cells","volume":"3","author":"Urdahl","year":"2002","journal-title":"Nat. Immunol."},{"key":"2025032409591259700_r16","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1084\/jem.191.5.771","article-title":"Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice","volume":"191","author":"Kennedy","year":"2000","journal-title":"J. Exp. Med."},{"key":"2025032409591259700_r17","doi-asserted-by":"crossref","first-page":"12492","DOI":"10.1073\/pnas.95.21.12492","article-title":"Major histocompatibility complex (MHC) class I KbDb -\/- deficient mice possess functional CD8+ T cells and natural killer cells","volume":"95","author":"Vugmeyster","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032409591259700_r18"},{"key":"2025032409591259700_r19"},{"key":"2025032409591259700_r20","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/nbt1215","article-title":"A consensus epitope prediction approach identifies the breadth of murine T(CD8+)-cell responses to vaccinia virus","volume":"24","author":"Moutaftsi","year":"2006","journal-title":"Nat. Biotechnol."},{"key":"2025032409591259700_r21","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.4049\/jimmunol.180.4.2099","article-title":"Preassociation of IL-15 with IL-15R alpha-IgG1-Fc enhances its activity on proliferation of NK and CD8+\/CD44high T cells and its antitumor action","volume":"180","author":"Dubois","year":"2008","journal-title":"J. Immunol."},{"key":"2025032409591259700_r22","doi-asserted-by":"crossref","first-page":"9166","DOI":"10.1073\/pnas.0600240103","article-title":"Converting IL-15 to a superagonist by binding to soluble IL-15Ralpha","volume":"103","author":"Rubinstein","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032409591259700_r23","doi-asserted-by":"crossref","first-page":"6537","DOI":"10.4049\/jimmunol.173.11.6537","article-title":"Cutting edge: transpresentation of IL-15 by bone marrow-derived cells necessitates expression of IL-15 and IL-15R alpha by the same cells","volume":"173","author":"Sandau","year":"2004","journal-title":"J. Immunol."},{"key":"2025032409591259700_r24","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1182\/blood-2003-08-2814","article-title":"Transregulation of memory CD8 T-cell proliferation by IL-15Ralpha+ bone marrow-derived cells","volume":"103","author":"Schluns","year":"2004","journal-title":"Blood"},{"key":"2025032409591259700_r25","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nri1052","article-title":"Cytokine control of memory T-cell development and survival","volume":"3","author":"Schluns","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"2025032409591259700_r26","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.0105-2896.2006.00401.x","article-title":"Homeostasis of memory T cells","volume":"211","author":"Surh","year":"2006","journal-title":"Immunol. Rev."},{"key":"2025032409591259700_r27","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.0105-2896.2006.00389.x","article-title":"Developing and maintaining protective CD8+ memory T cells","volume":"211","author":"Williams","year":"2006","journal-title":"Immunol. Rev."},{"key":"2025032409591259700_r28","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nature09370","article-title":"Inhibition of follicular T-helper cells by CD8(+) regulatory T cells is essential for self tolerance","volume":"467","author":"Kim","year":"2010","journal-title":"Nature"},{"key":"2025032409591259700_r29","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.immuni.2006.05.012","article-title":"The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells","volume":"25","author":"Atherly","year":"2006","journal-title":"Immunity"},{"key":"2025032409591259700_r30","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.immuni.2006.05.011","article-title":"Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk","volume":"25","author":"Broussard","year":"2006","journal-title":"Immunity"},{"key":"2025032409591259700_r31","doi-asserted-by":"crossref","first-page":"12075","DOI":"10.1073\/pnas.0605212103","article-title":"ITK and IL-15 support two distinct subsets of CD8+ T cells","volume":"103","author":"Dubois","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032409591259700_r32","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.4049\/jimmunol.0901872","article-title":"Cutting edge: IL-15-independent NK cell response to mouse cytomegalovirus infection","volume":"183","author":"Sun","year":"2009","journal-title":"J. Immunol."},{"key":"2025032409591259700_r33","first-page":"157","article-title":"Dendritic cell-NK cell cross-talk: regulation and physiopathology","volume":"298","author":"Zitvogel","year":"2006","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"2025032409591259700_r34","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nri798","article-title":"T-cell development and the CD4-CD8 lineage decision","volume":"2","author":"Germain","year":"2002","journal-title":"Nat. Rev. Immunol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/188\/6\/2575\/61631558\/1102393.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/188\/6\/2575\/61631558\/1102393.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T18:25:33Z","timestamp":1743099933000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/188\/6\/2575\/7981314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,3,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1102393","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2012,3]]},"published":{"date-parts":[[2012,3]]}}}