{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:22:38Z","timestamp":1792506158298,"version":"4.5.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A small number of HIV-infected individuals known as elite controllers experience low levels of chronic phase viral replication and delayed progression to AIDS. Specific HLA class I alleles are associated with elite control, implicating CD8+ T lymphocytes in the establishment of these low levels of viral replication. Most HIV-infected individuals that express protective HLA class I alleles, however, do not control viral replication. Approximately 50% of Mamu-B*00801+ Indian rhesus macaques control SIVmac239 replication in the chronic phase in a manner that resembles elite control in humans. We followed both the immune response and viral evolution in SIV-infected Mamu-B*00801+ animals to better understand the role of CD8+ T lymphocytes during the acute phase of viral infection, when viral control status is determined. The virus escaped from immunodominant Vif and Nef Mamu-B*00801\u2013restricted CD8+ T lymphocyte responses during the critical early weeks of acute infection only in progressor animals that did not control viral replication. Thus, early CD8+ T lymphocyte escape is a hallmark of Mamu-B*00801+ macaques who do not control viral replication. By contrast, virus in elite controller macaques showed little evidence of variation in epitopes recognized by immunodominant CD8+ T lymphocytes, implying that these cells play a role in viral control.<\/jats:p>","DOI":"10.4049\/jimmunol.1102470","type":"journal-article","created":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T20:05:47Z","timestamp":1330977947000},"page":"3364-3370","source":"Crossref","is-referenced-by-count":34,"title":["Escape from CD8+ T Cell Responses in <i>Mamu-B*00801<\/i>+ Macaques Differentiates Progressors from Elite Controllers"],"prefix":"10.1093","volume":"188","author":[{"given":"Philip A","family":"Mudd","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison , Madison, WI 53711"},{"name":"Medical Scientist Training Program, University of Wisconsin-Madison , Madison, WI 53705"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J","family":"Ericsen","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison , Madison, WI 53711"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin J","family":"Burwitz","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison , Madison, WI 53711"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy A","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison , Madison, WI 53711"},{"name":"Wisconsin National Primate Research Center, University of Wisconsin-Madison , Madison, WI 53711"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H","family":"O\u2019Connor","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison , Madison, WI 53711"},{"name":"Wisconsin National Primate Research Center, University of Wisconsin-Madison , Madison, WI 53711"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austin L","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of South Carolina , Columbia, SC 29208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David I","family":"Watkins","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison , Madison, WI 53711"},{"name":"Wisconsin National Primate Research Center, University of Wisconsin-Madison , Madison, WI 53711"},{"name":"Department of Pathology, University of Miami Miller School of Medicine , Miami, FL 33136"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,4,1]]},"reference":[{"key":"2025032409595678300_r1","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/nri2357","article-title":"Impact of MHC class I diversity on immune control of immunodeficiency virus replication","volume":"8","author":"Goulder","year":"2008","journal-title":"Nat. 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