{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:47:39Z","timestamp":1792180059243,"version":"4.4.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Group B Streptococcus (GBS) is a frequent agent of life-threatening sepsis and meningitis in neonates and adults with predisposing conditions. We tested the hypothesis that activation of the inflammasome, an inflammatory signaling complex, is involved in host defenses against this pathogen. We show in this study that murine bone marrow-derived conventional dendritic cells responded to GBS by secreting IL-1\u03b2 and IL-18. IL-1\u03b2 release required both pro\u2013IL-1\u03b2 transcription and caspase-1\u2013dependent proteolytic cleavage of intracellular pro\u2013IL-1\u03b2. Dendritic cells lacking the TLR adaptor MyD88, but not those lacking TLR2, were unable to produce pro\u2013IL-1\u03b2 mRNA in response to GBS. Pro\u2013IL-1\u03b2 cleavage and secretion of the mature IL-1\u03b2 form depended on the NOD-like receptor family, pyrin domain containing 3 (NLRP3) sensor and the apoptosis-associated speck-like protein containing a caspase activation and recruitment domain adaptor. Moreover, activation of the NLRP3 inflammasome required GBS expression of \u03b2-hemolysin, an important virulence factor. We further found that mice lacking NLRP3, apoptosis-associated speck-like protein, or caspase-1 were considerably more susceptible to infection than wild-type mice. Our data link the production of a major virulence factor by GBS with the activation of a highly effective anti-GBS response triggered by the NLRP3 inflammasome.<\/jats:p>","DOI":"10.4049\/jimmunol.1102543","type":"journal-article","created":{"date-parts":[[2012,1,16]],"date-time":"2012-01-16T23:56:36Z","timestamp":1326758196000},"page":"1953-1960","source":"Crossref","is-referenced-by-count":142,"title":["Activation of the NLRP3 Inflammasome by Group B Streptococci"],"prefix":"10.1093","volume":"188","author":[{"given":"Alessandro","family":"Costa","sequence":"first","affiliation":[{"name":"Elie Metchnikoff Department, University of Messina , Messina I-98125 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Immunology, University of Massachusetts Medical School , Worcester, MA 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,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelina","family":"Midiri","sequence":"additional","affiliation":[{"name":"Elie Metchnikoff Department, University of Messina , Messina I-98125 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Galbo","sequence":"additional","affiliation":[{"name":"Elie Metchnikoff Department, University of Messina , Messina I-98125 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Trieu-Cuot","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unit\u00e9 de Biologie des Bact\u00e9ries Pathog\u00e8nes \u00e0 Gram-Positif, Centre National de la Recherche Scientifique Unit\u00e9 de Recherche Associ\u00e9e \u00a0 2172, Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Papasergi","sequence":"additional","affiliation":[{"name":"Elie Metchnikoff Department, University of Messina , Messina I-98125 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Teti","sequence":"additional","affiliation":[{"name":"Elie Metchnikoff Department, University of Messina , Messina I-98125 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Henneke","sequence":"additional","affiliation":[{"name":"Centre of Chronic Immunodeficiency, Medical Centre, University Freiburg , Freiburg 79106 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Mancuso","sequence":"additional","affiliation":[{"name":"Elie Metchnikoff Department, University of Messina , Messina I-98125 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas T","family":"Golenbock","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Immunology, University 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