{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:14:21Z","timestamp":1791080061287,"version":"4.1.0"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Persistent exposure to cognate Ag leads to the functional impairment and exhaustion of HIV-specific CD8 T cells. Ag withdrawal, attributable either to antiretroviral treatment or the emergence of epitope escape mutations, causes HIV-specific CD8 T cell responses to wane over time. However, this process does not continue to extinction, and residual CD8 T cells likely play an important role in the control of HIV replication. In this study, we conducted a longitudinal analysis of clonality, phenotype, and function to define the characteristics of HIV-specific CD8 T cell populations that persist under conditions of limited antigenic stimulation. Ag decay was associated with dynamic changes in the TCR repertoire, increased expression of CD45RA and CD127, decreased expression of programmed death-1, and the emergence of polyfunctional HIV-specific CD8 T cells. High-definition analysis of individual clonotypes revealed that the Ag loss-induced gain of function within HIV-specific CD8 T cell populations could be attributed to two nonexclusive mechanisms: 1) functional improvement of persisting clonotypes; and 2) recruitment of particular clonotypes endowed with superior functional capabilities.<\/jats:p>","DOI":"10.4049\/jimmunol.1102610","type":"journal-article","created":{"date-parts":[[2011,12,31]],"date-time":"2011-12-31T01:39:30Z","timestamp":1325295570000},"page":"1156-1167","source":"Crossref","is-referenced-by-count":38,"title":["Clonotype and Repertoire Changes Drive the Functional Improvement of HIV-Specific CD8 T Cell Populations under Conditions of Limited Antigenic Stimulation"],"prefix":"10.1093","volume":"188","author":[{"given":"Loury","family":"Janbazian","sequence":"first","affiliation":[{"name":"Laboratory of Immunology, Department of Microbiology and Immunology, University of Montreal , Montreal, Quebec H2X 1P1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Price","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"},{"name":"Institute of Infection and Immunity, Cardiff University School of Medicine , Cardiff CF14 4XN, Wales ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenda","family":"Canderan","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute\u2013Florida , Port St. Lucie, FL 34987"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelali","family":"Filali-Mouhim","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, Department of Microbiology and Immunology, University of Montreal , Montreal, Quebec H2X 1P1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tedi E","family":"Asher","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R","family":"Ambrozak","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Scheinberg","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad Rachid","family":"Boulassel","sequence":"additional","affiliation":[{"name":"Division of Hematology, Royal Victoria Hospital, McGill University Health Centre , Montreal, Quebec H3A 1A1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Routy","sequence":"additional","affiliation":[{"name":"Division of Hematology, Royal Victoria Hospital, McGill University Health Centre , Montreal, Quebec H3A 1A1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A","family":"Koup","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C","family":"Douek","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafick-Pierre","family":"Sekaly","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, Department of Microbiology and Immunology, University of Montreal , Montreal, Quebec H2X 1P1 ,","place":["Canada"]},{"name":"Vaccine and Gene Therapy Institute\u2013Florida , Port St. Lucie, FL 34987"},{"name":"Faculty of Medicine, Department of Microbiology and Immunology, McGill University , Montreal, Quebec H3A 2B4 ,","place":["Canada"]},{"name":"Department of Microbiology and Immunology, Miller School of Medicine, University of Miami , Miami, FL 33101"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydie","family":"Trautmann","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute\u2013Florida , Port St. Lucie, FL 34987"},{"name":"Department of Microbiology and Immunology, Miller School of Medicine, University of Miami , Miami, FL 33101"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,2,1]]},"reference":[{"key":"2025032409474411000_r1","doi-asserted-by":"crossref","first-page":"6103","DOI":"10.1128\/jvi.68.9.6103-6110.1994","article-title":"Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection","volume":"68","author":"Borrow","year":"1994","journal-title":"J. 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