{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:15:04Z","timestamp":1790936104194,"version":"4.1.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>IL-21 induces the differentiation of activated B lymphocytes into plasma cells (PC), but its direct effect on PC remains uncertain. This study analyzes the role of IL-21 on human in vivo-generated PC. IL-21R was clearly expressed on PC from the human tonsil, the lymph node, and the spleen (secondary lymphoid organs [SLO]) but barely on terminally mature bone marrow PC. IL-21 enhanced Ig secretion by isolated SLO PC but not bone marrow PC. Tonsillar T follicular helper (Tfh) lymphocytes are known to secrete IL-21. Purified Tfh cells induced a marked increase of Ig production by tonsillar PC, and this effect was impaired when endogenous IL-21 production was blocked. IL-21 provoked a rapid and transient phosphorylation of STAT3 in tonsillar PC. Tfh cells or exogenous IL-21 reduce tonsillar PC apoptosis and increases PC recovery but does not modify their nonproliferating status. These results suggest that IL-21 derived from Tfh cells acts as a survival factor for SLO PC in vivo.<\/jats:p>","DOI":"10.4049\/jimmunol.1102786","type":"journal-article","created":{"date-parts":[[2012,1,16]],"date-time":"2012-01-16T23:56:36Z","timestamp":1326758196000},"page":"1578-1581","source":"Crossref","is-referenced-by-count":34,"title":["Cutting Edge: IL-21 Derived from Human Follicular Helper T Cells Acts as a Survival Factor for Secondary Lymphoid Organ, but Not for Bone Marrow, Plasma Cells"],"prefix":"10.1093","volume":"188","author":[{"given":"Beatriz","family":"Rodr\u00edguez-Bayona","sequence":"first","affiliation":[{"name":"Servicio de Inmunolog\u00eda, Unidad de Investigaci\u00f3n, Hospital Universitario Puerta del Mar , 11009 C\u00e1diz ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Ramos-Amaya","sequence":"additional","affiliation":[{"name":"Servicio de Inmunolog\u00eda, Unidad de Investigaci\u00f3n, Hospital Universitario Puerta del Mar , 11009 C\u00e1diz ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Bernal","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, Hospital Universitario Puerta del Mar , 11009 C\u00e1diz ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Campos-Caro","sequence":"additional","affiliation":[{"name":"Servicio de Inmunolog\u00eda, Unidad de Investigaci\u00f3n, Hospital Universitario Puerta del Mar , 11009 C\u00e1diz ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A","family":"Brieva","sequence":"additional","affiliation":[{"name":"Servicio de Inmunolog\u00eda, Unidad de Investigaci\u00f3n, Hospital Universitario Puerta del Mar , 11009 C\u00e1diz ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,2,15]]},"reference":[{"key":"2025032409520000200_r1","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.4049\/jimmunol.109.6.1386","article-title":"Immunoglobulin synthesis by human lymphoid tissues: normal bone marrow as a major site of IgG production","volume":"109","author":"McMillan","year":"1972","journal-title":"J. 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