{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T01:38:31Z","timestamp":1786325911309,"version":"build-2736575974"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Exacerbation of chronic psoriasis can be associated with streptococcal throat infections, and T cells that respond to peptide sequences common to streptococcal M proteins and skin keratins have been detected in patients\u2019 blood. To our knowledge, we have conducted the first blinded, prospective study to assess the impact of tonsillectomy on psoriasis. Twenty-nine patients with chronic psoriasis and history of exacerbation after sore throat were randomly assigned to tonsillectomy (n = 15) or control (n = 14) groups and monitored for 2 y clinically and by enumeration of circulating skin homing T cells that respond to short homologous M protein or keratin peptides. Thirteen patients (86%) showed sustained improvement after tonsillectomy ranging from 30 to 90% reduction in disease severity. Furthermore, there was a close correlation between the degree of clinical improvement in individual patients and reduction in the frequency of peptide-reactive skin-homing T cells in their circulation. No corresponding clinical or immunologic changes were observed among the controls. These findings indicate that tonsillectomy may have a beneficial effect on chronic psoriasis because the palatine tonsils generate effector T cells that recognize keratin determinants in the skin.<\/jats:p>","DOI":"10.4049\/jimmunol.1102834","type":"journal-article","created":{"date-parts":[[2012,4,10]],"date-time":"2012-04-10T01:07:12Z","timestamp":1334020032000},"page":"5160-5165","source":"Crossref","is-referenced-by-count":90,"title":["Improvement of Psoriasis after Tonsillectomy Is Associated with a Decrease in the Frequency of Circulating T Cells That Recognize Streptococcal Determinants and Homologous Skin Determinants"],"prefix":"10.1093","volume":"188","author":[{"given":"Ragna Hlin","family":"Thorleifsdottir","sequence":"first","affiliation":[{"name":"Department of Immunology, Landspitali University Hospital , 101 Reykjavik ,","place":["Iceland"]},{"name":"Department of Dermatology, Landspitali University Hospital , 101 Reykjavik ,","place":["Iceland"]},{"name":"Faculty of Medicine, University of Iceland , 101 Reykjavik ,","place":["Iceland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrun Laufey","family":"Sigurdardottir","sequence":"additional","affiliation":[{"name":"Department of Immunology, Landspitali University Hospital , 101 Reykjavik ,","place":["Iceland"]},{"name":"Faculty of Medicine, University of Iceland , 101 Reykjavik ,","place":["Iceland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bardur","family":"Sigurgeirsson","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Landspitali University Hospital , 101 Reykjavik ,","place":["Iceland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon Hjaltalin","family":"Olafsson","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Landspitali University Hospital , 101 Reykjavik ,","place":["Iceland"]},{"name":"Faculty of Medicine, University of Iceland , 101 Reykjavik ,","place":["Iceland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin Ingi","family":"Sigurdsson","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Iceland , 101 Reykjavik ,","place":["Iceland"]},{"name":"Department of Medicine, Landspitali University Hospital , 101 Reykjavik ,","place":["Iceland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannes","family":"Petersen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Iceland , 101 Reykjavik ,","place":["Iceland"]},{"name":"Department of Ear, Nose, and Throat, Landspitali University Hospital , 101 Reykjavik ,","place":["Iceland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigurlaug","family":"Arnadottir","sequence":"additional","affiliation":[{"name":"Department of Immunology, Landspitali University Hospital , 101 Reykjavik ,","place":["Iceland"]},{"name":"Faculty of Medicine, University of Iceland , 101 Reykjavik ,","place":["Iceland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann Eli","family":"Gudjonsson","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Michigan , Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Michigan , Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helgi","family":"Valdimarsson","sequence":"additional","affiliation":[{"name":"Department of Immunology, Landspitali University Hospital , 101 Reykjavik ,","place":["Iceland"]},{"name":"Faculty of Medicine, University of Iceland , 101 Reykjavik ,","place":["Iceland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,5,15]]},"reference":[{"key":"2025032410085282700_r1","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.it.2009.07.008","article-title":"Psoriasis: as an autoimmune disease caused by molecular mimicry","volume":"30","author":"Valdimarsson","year":"2009","journal-title":"Trends Immunol."},{"key":"2025032410085282700_r2","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/nm1605","article-title":"\u03b11\u03b21 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis","volume":"13","author":"Conrad","year":"2007","journal-title":"Nat. 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