{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:04:47Z","timestamp":1787069087695,"version":"build-2736575974"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Negative regulation of innate immune responses is essential to prevent excess inflammation and tissue injury and promote homeostasis. Lysophosphatidic acid (LPA) is a pleiotropic lipid that regulates cell growth, migration, and activation and is constitutively produced at low levels in tissues and in serum. Extracellular LPA binds to specific G protein-coupled receptors, whose function in regulating innate or adaptive immune responses remains poorly understood. Of the classical LPA receptors belonging to the Edg family, lpa2 (edg4) is expressed by dendritic cells (DC) and other innate immune cells. In this article, we show that DC from lpa2\u2212\/\u2212 mice are hyperactive compared with their wild-type counterparts and are less susceptible to inhibition by different LPA species. In transient-transfection assays, we found that lpa2 overexpression inhibits NF-\u03baB\u2013driven gene transcription. Using an adoptive-transfer approach, we found that allergen-pulsed lpa2\u2212\/\u2212 DC induced substantially more lung inflammation than did wild-type DC after inhaled allergen challenge. Finally, lpa2\u2212\/\u2212 mice develop greater allergen-driven lung inflammation than do their wild-type counterparts in models of allergic asthma involving both systemic and mucosal sensitization. Taken together, these findings identify LPA acting via lpa2 as a novel negative regulatory pathway that inhibits DC activation and allergic airway inflammation.<\/jats:p>","DOI":"10.4049\/jimmunol.1102956","type":"journal-article","created":{"date-parts":[[2012,3,17]],"date-time":"2012-03-17T00:37:34Z","timestamp":1331944654000},"page":"3784-3790","source":"Crossref","is-referenced-by-count":50,"title":["Lpa2 Is a Negative Regulator of Both Dendritic Cell Activation and Murine Models of Allergic Lung Inflammation"],"prefix":"10.1093","volume":"188","author":[{"given":"Jason","family":"Emo","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Rochester Medical Center , Rochester, NY 14610"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nida","family":"Meednu","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Rochester Medical Center , Rochester, NY 14610"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J","family":"Chapman","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Rochester Medical Center , Rochester, NY 14610"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariba","family":"Rezaee","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonary Medicine, Department of Pediatrics, University of Rochester Medical Center , Rochester, NY 14610"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlene","family":"Balys","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Rochester Medical Center , Rochester, NY 14610"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troy","family":"Randall","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Rochester Medical Center , Rochester, NY 14610"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tirumalai","family":"Rangasamy","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Rochester Medical Center , Rochester, NY 14610"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve N","family":"Georas","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Rochester Medical Center , Rochester, NY 14610"},{"name":"Department of Microbiology and Immunology, University of Rochester Medical Center , Rochester, NY 14610"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,4,15]]},"reference":[{"key":"2025032410034432000_r1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1146\/annurev.pharmtox.010909.105753","article-title":"LPA receptors: subtypes and biological actions","volume":"50","author":"Choi","year":"2010","journal-title":"Annu. 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