{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:36:12Z","timestamp":1791272172361,"version":"4.1.0"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>An increasing number of neurologic diseases is associated with autoimmunity. The immune effectors contributing to the pathogenesis of such diseases are often unclear. To explore whether self-reactive CD8 T cells could attack CNS neurons in vivo, we generated a mouse model in which the influenza virus hemagglutinin (HA) is expressed specifically in CNS neurons. Transfer of cytotoxic anti-HA CD8 T cells induced an acute but reversible encephalomyelitis in HA-expressing recipient mice. Unexpectedly, diabetes insipidus developed in surviving animals. This robust phenotype was associated with preferential accumulation of cytotoxic CD8 T cells in the hypothalamus, upregulation of MHC class I molecules, and destruction of vasopressin-expressing neurons. IFN-\u03b3 production by the pathogenic CD8 T cells was necessary for MHC class I upregulation by hypothalamic neurons and their destruction. This novel mouse model, in combination with related human data, supports the concept that autoreactive CD8 T cells can trigger central diabetes insipidus.<\/jats:p>","DOI":"10.4049\/jimmunol.1102998","type":"journal-article","created":{"date-parts":[[2012,4,14]],"date-time":"2012-04-14T05:00:21Z","timestamp":1334379621000},"page":"4731-4735","source":"Crossref","is-referenced-by-count":29,"title":["Cutting Edge: Neuronal Recognition by CD8 T Cells Elicits Central Diabetes Insipidus"],"prefix":"10.1093","volume":"188","author":[{"given":"Tanja","family":"Scheikl","sequence":"first","affiliation":[{"name":"INSERM , U1043, Toulouse F-31300 ,","place":["France"]},{"name":"Centre National de la Recherche Scientifique , U5282, Toulouse F-31300 ,","place":["France"]},{"name":"Universit\u00e9 de Toulouse, Universit\u00e9 Paul Sabatier, Centre de Physiopathologie de Toulouse Purpan , Toulouse F-31300 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Pignolet","sequence":"additional","affiliation":[{"name":"INSERM , U1043, Toulouse F-31300 ,","place":["France"]},{"name":"Centre National de la Recherche Scientifique , U5282, Toulouse F-31300 ,","place":["France"]},{"name":"Universit\u00e9 de Toulouse, Universit\u00e9 Paul Sabatier, Centre de Physiopathologie de Toulouse Purpan , Toulouse F-31300 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Dalard","sequence":"additional","affiliation":[{"name":"INSERM , U1043, Toulouse F-31300 ,","place":["France"]},{"name":"Centre National de la Recherche Scientifique , U5282, Toulouse F-31300 ,","place":["France"]},{"name":"Universit\u00e9 de Toulouse, Universit\u00e9 Paul Sabatier, Centre de Physiopathologie de Toulouse Purpan , Toulouse F-31300 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Desbois","sequence":"additional","affiliation":[{"name":"INSERM , U1043, Toulouse F-31300 ,","place":["France"]},{"name":"Centre National de la Recherche Scientifique , U5282, Toulouse F-31300 ,","place":["France"]},{"name":"Universit\u00e9 de Toulouse, Universit\u00e9 Paul Sabatier, Centre de Physiopathologie de Toulouse Purpan , Toulouse F-31300 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dani\u00e8le","family":"Raison","sequence":"additional","affiliation":[{"name":"INSERM , U952, Universit\u00e9 Paris 6, Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Institute on Aging and Adaptation, Shinshu University Graduate School , Matsumoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelhadi","family":"Saoudi","sequence":"additional","affiliation":[{"name":"INSERM , U1043, Toulouse F-31300 ,","place":["France"]},{"name":"Centre National de la Recherche Scientifique , U5282, Toulouse F-31300 ,","place":["France"]},{"name":"Universit\u00e9 de Toulouse, Universit\u00e9 Paul Sabatier, Centre de Physiopathologie de Toulouse Purpan , Toulouse F-31300 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Bauer","sequence":"additional","affiliation":[{"name":"Center for Brain Research, Medical University of Vienna , Vienna ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Lassmann","sequence":"additional","affiliation":[{"name":"Center for Brain Research, Medical University of Vienna , Vienna ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Hardin-Pouzet","sequence":"additional","affiliation":[{"name":"INSERM , U952, Universit\u00e9 Paris 6, Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland S","family":"Liblau","sequence":"additional","affiliation":[{"name":"INSERM , U1043, Toulouse F-31300 ,","place":["France"]},{"name":"Centre National de la Recherche Scientifique , U5282, Toulouse F-31300 ,","place":["France"]},{"name":"Universit\u00e9 de Toulouse, Universit\u00e9 Paul Sabatier, Centre de Physiopathologie de Toulouse Purpan , Toulouse F-31300 ,","place":["France"]},{"name":"Centre Hospitalier Universitaire Toulouse, H\u00f4pital Purpan, D\u00e9partement d\u2019Immunologie , Toulouse F-31300 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,5,15]]},"reference":[{"key":"2025032410093692000_r1","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/nri2527","article-title":"Antiviral immune responses: triggers of or triggered by autoimmunity?","volume":"9","author":"M\u00fcnz","year":"2009","journal-title":"Nat. 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