{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:43:48Z","timestamp":1792640628081,"version":"4.5.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>P-selectin glycoprotein ligand-1 (PSGL-1), a heavily glycosylated sialomucin expressed on most leukocytes, has dual function as a selectin ligand for leukocyte rolling on vascular selectins expressed in inflammation and as a facilitator of resting T cell homing into lymphoid organs. In this article, we document disturbances in T cell homeostasis present in PSGL-1null mice. Naive CD4+ and CD8+ T cell frequencies were profoundly reduced in blood, whereas T cell numbers in lymph nodes and spleen were at or near normal levels. Although PSGL-1null T cells were less efficient at entering lymph nodes, they also remained in lymph nodes longer than PSGL-1+\/+ T cells, suggesting that PSGL-1 supports T cell egress. In addition, PSGL-1null CD8+ T cell proliferation was observed under steady-state conditions and PSGL-1null CD8+ T cells were found to be hyperresponsive to homeostatic cytokines IL-2, IL-4, and IL-15. Despite these disturbances in T cell homeostasis, PSGL-1null mice exhibited a normal acute response (day 8) to lymphocytic choriomeningitis virus infection but generated an increased frequency of memory T cells (day 40). Our observations demonstrate a novel pleiotropic influence of PSGL-1 deficiency on several aspects of T cell homeostasis that would not have been anticipated based on the mild phenotype of PSGL-1null mice. These potentially offsetting effects presumably account for the near-normal cellularity seen in lymph nodes of PSGL-1null mice.<\/jats:p>","DOI":"10.4049\/jimmunol.1103026","type":"journal-article","created":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T04:56:36Z","timestamp":1326776196000},"page":"1638-1646","source":"Crossref","is-referenced-by-count":29,"title":["PSGL-1 Regulates the Migration and Proliferation of CD8+ T Cells under Homeostatic Conditions"],"prefix":"10.1093","volume":"188","author":[{"given":"Krystle M","family":"Veerman","sequence":"first","affiliation":[{"name":"Biomedical Research Centre, University of British Columbia , Vancouver, British Columbia V6T 1Z3 ,","place":["Canada"]},{"name":"Department of Pathology and Laboratory Medicine, University of British Columbia , Vancouver, British Columbia V6T 1Z3 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas A","family":"Carlow","sequence":"additional","affiliation":[{"name":"Biomedical Research Centre, University of British Columbia , Vancouver, British Columbia V6T 1Z3 ,","place":["Canada"]},{"name":"Department of Pathology and Laboratory Medicine, University of British Columbia , Vancouver, British Columbia V6T 1Z3 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iryna","family":"Shanina","sequence":"additional","affiliation":[{"name":"Infection, Inflammation and Immunity Research Group, Life Sciences Institute, University of British Columbia , Vancouver, British Columbia V6T 1Z3 ,","place":["Canada"]},{"name":"Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia , Vancouver, British Columbia V6T 1Z3 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J","family":"Priatel","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of British Columbia , Vancouver, British Columbia V6T 1Z3 ,","place":["Canada"]},{"name":"Child and Family Research Institute, University of British Columbia , Vancouver, British Columbia V5Z 4H4 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc S","family":"Horwitz","sequence":"additional","affiliation":[{"name":"Infection, Inflammation and Immunity Research Group, Life Sciences Institute, University of British Columbia , Vancouver, British Columbia V6T 1Z3 ,","place":["Canada"]},{"name":"Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia , Vancouver, British Columbia V6T 1Z3 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann J","family":"Ziltener","sequence":"additional","affiliation":[{"name":"Biomedical Research Centre, University of British Columbia , Vancouver, British Columbia V6T 1Z3 ,","place":["Canada"]},{"name":"Department of Pathology and Laboratory Medicine, University of British Columbia , Vancouver, British Columbia V6T 1Z3 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,2,15]]},"reference":[{"key":"2025032409521306200_r1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.immunol.23.021704.115715","article-title":"Zoned out: functional mapping of stromal signaling microenvironments in the thymus","volume":"25","author":"Petrie","year":"2007","journal-title":"Annu. 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