{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T11:16:45Z","timestamp":1781090205607,"version":"3.54.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Stromal keratitis is a chronic immunopathological lesion of the eye caused by HSV-1 infection that can result in blindness. Because the inflammatory lesions are primarily orchestrated by Th1 cells, and to a lesser extent by Th17 cells, inhibiting their activity represents a useful form of therapy. In this study we evaluated the therapeutic potential of galectin-1 (gal-1), an endogenous lectin that in some autoimmune diseases was shown to suppress the functions of Th1 and Th17 cells. Treatment was begun at different times after ocular infection with HSV and the outcome was assessed clinically as well as for effects on various immune parameters. Treatment with recombinant gal-1 significantly diminished stromal keratitis lesion severity and the extent of corneal neovascularization. Treated mice had reduced numbers of IFN-\u03b3\u2013 and IL-17\u2013producing CD4+ T cells, as well as neutrophil infiltration in the cornea. Furthermore, disease severity was greater in gal-1 knockout mice compared with their wild-type counterparts. The many effects of gal-1 treatment include reduction in the production of proinflammatory cytokines and chemokines, increased production of IL-10, and inhibitory effects on molecules involved in neovascularization. To our knowledge, our findings are the first to show that gal-1 treatment represents a useful approach to control lesion severity in a virally induced immunopathological disease.<\/jats:p>","DOI":"10.4049\/jimmunol.1103063","type":"journal-article","created":{"date-parts":[[2012,3,31]],"date-time":"2012-03-31T05:12:54Z","timestamp":1333170774000},"page":"4631-4643","source":"Crossref","is-referenced-by-count":51,"title":["Galectin-1 Reduces the Severity of Herpes Simplex Virus-Induced Ocular Immunopathological Lesions"],"prefix":"10.1093","volume":"188","author":[{"given":"Naveen K","family":"Rajasagi","sequence":"first","affiliation":[{"name":"Comparative and Experimental Medicine, College of Veterinary Medicine, University of Tennessee , Knoxville, TN 37996"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amol","family":"Suryawanshi","sequence":"additional","affiliation":[{"name":"Yerkes National Primate Research Center, Department of Pathology, Emory University School of Medicine , Atlanta, GA 30329"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharvan","family":"Sehrawat","sequence":"additional","affiliation":[{"name":"Whitehead Institute for Biomedical Research , Cambridge, MA 02142"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep B J","family":"Reddy","sequence":"additional","affiliation":[{"name":"Comparative and Experimental Medicine, College of Veterinary Medicine, University of Tennessee , Knoxville, TN 37996"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Mulik","sequence":"additional","affiliation":[{"name":"Comparative and Experimental Medicine, College of Veterinary Medicine, University of Tennessee , Knoxville, TN 37996"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuomi","family":"Hirashima","sequence":"additional","affiliation":[{"name":"Department of Immunology and Immunopathology, Faculty of Medicine, Kagawa University , Kagawa 761-0793 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry T","family":"Rouse","sequence":"additional","affiliation":[{"name":"Comparative and Experimental Medicine, College of Veterinary Medicine, University of Tennessee , Knoxville, TN 37996"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,5,1]]},"reference":[{"key":"2025032410060061200_r1","first-page":"905","volume-title":"Ocular Infection and Immunity,","author":"Pepose","year":"1996"},{"key":"2025032410060061200_r2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00003226-200101000-00001","article-title":"Herpes simplex virus epidemiology and ocular importance","volume":"20","author":"Liesegang","year":"2001","journal-title":"Cornea"},{"key":"2025032410060061200_r3","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.4049\/jimmunol.149.9.3035","article-title":"Predominance of Th1 cells in ocular tissues during herpetic stromal keratitis","volume":"149","author":"Niemialtowski","year":"1992","journal-title":"J. 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