{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T12:06:19Z","timestamp":1785326779856,"version":"3.55.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Vaccination with purified capsular polysaccharide Vi Ag from Salmonella typhi can protect against typhoid fever, although the mechanism for its efficacy is not clearly established. In this study, we have characterized the B cell response to this vaccine in wild-type and T cell\u2013deficient mice. We show that immunization with typhoid vi polysaccharide vaccine rapidly induces proliferation in B1b peritoneal cells, but not in B1a cells or marginal zone B cells. This induction of B1b proliferation is concomitant with the detection of splenic Vi-specific Ab-secreting cells and protective Ab in Rag1-deficient B1b cell chimeras generated by adoptive transfer-induced specific Ab after Vi immunization. Furthermore, Ab derived from peritoneal B cells is sufficient to confer protection against Salmonella that express Vi Ag. Expression of Vi by Salmonella during infection did not inhibit the development of early Ab responses to non-Vi Ags. Despite this, the protection conferred by immunization of mice with porin proteins from Salmonella, which induce Ab-mediated protection, was reduced postinfection with Vi-expressing Salmonella, although protection was not totally abrogated. This work therefore suggests that, in mice, B1b cells contribute to the protection induced by Vi Ag, and targeting non-Vi Ags as subunit vaccines may offer an attractive strategy to augment current Vi-based vaccine strategies.<\/jats:p>","DOI":"10.4049\/jimmunol.1103166","type":"journal-article","created":{"date-parts":[[2012,11,17]],"date-time":"2012-11-17T02:17:00Z","timestamp":1353118620000},"page":"5527-5532","source":"Crossref","is-referenced-by-count":52,"title":["The Capsular Polysaccharide Vi from <i>Salmonella<\/i> Typhi Is a B1b Antigen"],"prefix":"10.1093","volume":"189","author":[{"given":"Jennifer L","family":"Marshall","sequence":"first","affiliation":[{"name":"Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, Institute for Biomedical Research, University of Birmingham , Edgbaston, Birmingham B15 2TT,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Flores-Langarica","sequence":"additional","affiliation":[{"name":"Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, Institute for Biomedical Research, University of Birmingham , Edgbaston, Birmingham B15 2TT,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A","family":"Kingsley","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute , Hinxton, Cambridge CB10 1SA,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica R","family":"Hitchcock","sequence":"additional","affiliation":[{"name":"Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, Institute for Biomedical Research, University of Birmingham , Edgbaston, Birmingham B15 2TT,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewan A","family":"Ross","sequence":"additional","affiliation":[{"name":"Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, Institute for Biomedical Research, University of Birmingham , Edgbaston, Birmingham B15 2TT,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantino","family":"L\u00f3pez-Mac\u00edas","sequence":"additional","affiliation":[{"name":"Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre \u201cSiglo XXI\u201d Mexican Institute for Social Security , Mexico City 6900,","place":["Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Lakey","sequence":"additional","affiliation":[{"name":"Institute for Cell and Molecular Biosciences, University of Newcastle , Newcastle Upon Tyne NE2 4HH,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura B","family":"Martin","sequence":"additional","affiliation":[{"name":"Novartis Vaccines Institute for Global Health , 53100 Siena,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Michael","family":"Toellner","sequence":"additional","affiliation":[{"name":"Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, Institute for Biomedical Research, University of Birmingham , Edgbaston, Birmingham B15 2TT,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calman A","family":"MacLennan","sequence":"additional","affiliation":[{"name":"Novartis Vaccines Institute for Global Health , 53100 Siena,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian C","family":"MacLennan","sequence":"additional","affiliation":[{"name":"Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, Institute for Biomedical Research, University of Birmingham , Edgbaston, Birmingham B15 2TT,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian R","family":"Henderson","sequence":"additional","affiliation":[{"name":"Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, Institute for Biomedical Research, University of Birmingham , Edgbaston, Birmingham B15 2TT,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Dougan","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute , Hinxton, Cambridge CB10 1SA,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam F","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, Institute for Biomedical Research, University of Birmingham , Edgbaston, Birmingham B15 2TT,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,12,15]]},"reference":[{"key":"2025032409392099500_r1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1086\/649541","article-title":"Global trends in typhoid and paratyphoid fever","volume":"50","author":"Crump","year":"2010","journal-title":"Clin. 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