{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:31:40Z","timestamp":1791117100600,"version":"4.1.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Mechanistic understanding of RP105 has been confounded by the fact that this TLR homolog has appeared to have opposing, cell type-specific effects on TLR4 signaling. Although RP105 inhibits TLR4-driven signaling in cell lines and myeloid cells, impaired LPS-driven proliferation by B cells from RP105\u2212\/\u2212 mice has suggested that RP105 facilitates TLR4 signaling in B cells. In this article, we show that modulation of B cell proliferation by RP105 is not a function of B cell-intrinsic expression of RP105, and identify a mechanistic role for dysregulated BAFF expression in the proliferative abnormalities of B cells from RP105\u2212\/\u2212 mice: serum BAFF levels are elevated in RP105\u2212\/\u2212 mice, and partial BAFF neutralization rescues aberrant B cell proliferative responses in such mice. These data indicate that RP105 does not have dichotomous effects on TLR4 signaling and emphasize the need for caution in interpreting the results of global genetic deletion.<\/jats:p>","DOI":"10.4049\/jimmunol.1103282","type":"journal-article","created":{"date-parts":[[2012,1,31]],"date-time":"2012-01-31T08:03:34Z","timestamp":1327997014000},"page":"2065-2069","source":"Crossref","is-referenced-by-count":12,"title":["Cutting Edge: Regulation of TLR4-Driven B Cell Proliferation by RP105 Is Not B Cell Autonomous"],"prefix":"10.1093","volume":"188","author":[{"given":"Jessica L","family":"Allen","sequence":"first","affiliation":[{"name":"Division of Molecular Immunology, Cincinnati Children\u2019s Hospital Research Foundation , Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah M","family":"Flick","sequence":"additional","affiliation":[{"name":"Division of Molecular Immunology, Cincinnati Children\u2019s Hospital Research Foundation , Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senad","family":"Divanovic","sequence":"additional","affiliation":[{"name":"Division of Molecular Immunology, Cincinnati Children\u2019s Hospital Research Foundation , Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun W","family":"Jackson","sequence":"additional","affiliation":[{"name":"Seattle Children's Research Institute, University of Washington School of Medicine , Seattle, WA 98195"},{"name":"Department of Pediatrics, University of Washington School of Medicine , Seattle, WA 98195"},{"name":"Department of Immunology, University of Washington School of Medicine , Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Bram","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine, College of Medicine, Mayo Clinic , Rochester, MN 55905"},{"name":"Department of Immunology, College of Medicine, Mayo Clinic , Rochester, MN 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Rawlings","sequence":"additional","affiliation":[{"name":"Seattle Children's Research Institute, University of Washington School of Medicine , Seattle, WA 98195"},{"name":"Department of Pediatrics, University of Washington School of Medicine , Seattle, WA 98195"},{"name":"Department of Immunology, University of Washington School of Medicine , Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred D","family":"Finkelman","sequence":"additional","affiliation":[{"name":"Cincinnati Veterans Affairs Medical Center , Cincinnati, OH 45220"},{"name":"Department of Pediatrics, University of Cincinnati College of Medicine , Cincinnati, OH 45229"},{"name":"Division of Immunobiology, Cincinnati Children\u2019s Hospital Research Foundation , Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L","family":"Karp","sequence":"additional","affiliation":[{"name":"Division of Molecular Immunology, Cincinnati Children\u2019s Hospital Research Foundation , Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,3,1]]},"reference":[{"key":"2025032409534845100_r1","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1084\/jem.180.4.1217","article-title":"Murine B cell proliferation and protection from apoptosis with an antibody against a 105-kD molecule: unresponsiveness of X-linked immunodeficient B cells","volume":"180","author":"Miyake","year":"1994","journal-title":"J. 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