{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:17:40Z","timestamp":1791271060419,"version":"4.1.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Galectin-1 (Gal-1), a \u03b2-galactoside\u2013binding protein, can alter fate and effector function of Th cells; however, little is known about how Gal-1 induces Th cell differentiation. In this article, we show that both uncommitted and polarized Th cells bound by Gal-1 expressed an immunoregulatory signature defined by IL-10. IL-10 synthesis was stimulated by direct Gal-1 engagement to cell surface glycoproteins, principally CD45, on activated Th cells and enhanced by IL-21 expression through the c-Maf\/aryl hydrocarbon receptor pathway, independent of APCs. Gal-1\u2013induced IL-10+ T cells efficiently suppressed T cell proliferation and T cell-mediated inflammation and promoted the establishment of cancer immune-privileged sites. Collectively, these findings show how Gal-1 functions as a major glycome determinant regulating Th cell development, inflammation, and tumor immunity.<\/jats:p>","DOI":"10.4049\/jimmunol.1103433","type":"journal-article","created":{"date-parts":[[2012,2,18]],"date-time":"2012-02-18T05:26:59Z","timestamp":1329542819000},"page":"3127-3137","source":"Crossref","is-referenced-by-count":121,"title":["Galectin-1 Triggers an Immunoregulatory Signature in Th Cells Functionally Defined by IL-10 Expression"],"prefix":"10.1093","volume":"188","author":[{"given":"Filiberto","family":"Cedeno-Laurent","sequence":"first","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital , Boston, MA 02115"},{"name":"Harvard Medical School , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Opperman","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R","family":"Barthel","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital , Boston, MA 02115"},{"name":"Harvard Medical School , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay K","family":"Kuchroo","sequence":"additional","affiliation":[{"name":"Harvard Medical School , Boston, MA 02115"},{"name":"Department of Neurology, Brigham and Women\u2019s Hospital , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles J","family":"Dimitroff","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital , Boston, MA 02115"},{"name":"Harvard Medical School , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,4,1]]},"reference":[{"key":"2025032410010645000_r1","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/39614","article-title":"A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis","volume":"389","author":"Groux","year":"1997","journal-title":"Nature"},{"key":"2025032410010645000_r2","doi-asserted-by":"crossref","first-page":"797","DOI":"10.4049\/jimmunol.0901233","article-title":"Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells","volume":"183","author":"Pot","year":"2009","journal-title":"J. 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