{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:52:08Z","timestamp":1790254328337,"version":"4.1.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The polyunsaturated \u03c9-3 fatty acid eicosapentaenoic acid\u2013derived resolvin E1 (RvE1) enhances resolution of inflammation, prevents bone loss, and induces bone regeneration. Although the inflammation-resolving actions of RvE1 are characterized, the molecular mechanism of its bone-protective actions are of interest. To test the hypothesis that receptor-mediated events impact bone changes, we prepared transgenic mice overexpressing the RvE1 receptor chemokine-like receptor 1 (chemR23) on leukocytes. In zymosan-initiated peritonitis, neutrophil polymorphonuclear leukocyte infiltration in response to RvE1 was limited requiring log order lower doses in chemR23tg mice. Ligature-induced alveolar bone loss was diminished in chemR23tg mice. Local RvE1 treatment of uniform craniotomy in the parietal bone significantly accelerated regeneration of the bone defect. In in vitro bone cultures, RvE1 significantly enhanced expression of osteoprotegerin (OPG) without inducing change in receptor activator of NF-\u03baB ligand levels, whereas the osteogenic markers alkaline phosphatase, bone sialoprotein, and Runt-related transcription factor 2 remained unchanged. These results indicate that RvE1 modulates osteoclast differentiation and bone remodeling by direct actions on bone, rescuing OPG production and restoring a favorable receptor activator of NF-\u03baB ligand\/OPG ratio, in addition to known anti-inflammatory and proresolving actions.<\/jats:p>","DOI":"10.4049\/jimmunol.1103688","type":"journal-article","created":{"date-parts":[[2012,12,16]],"date-time":"2012-12-16T02:05:37Z","timestamp":1355623537000},"page":"689-694","source":"Crossref","is-referenced-by-count":115,"title":["Resolvin E1 and Chemokine-like Receptor 1 Mediate Bone Preservation"],"prefix":"10.1093","volume":"190","author":[{"given":"Li","family":"Gao","sequence":"first","affiliation":[{"name":"Goldman School of Dental Medicine, Boston University , Boston, MA 02118"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Faibish","sequence":"additional","affiliation":[{"name":"Goldman School of Dental Medicine, Boston University , Boston, MA 02118"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"Fredman","sequence":"additional","affiliation":[{"name":"Goldman School of Dental Medicine, Boston University , Boston, MA 02118"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno S","family":"Herrera","sequence":"additional","affiliation":[{"name":"The Forsyth Institute , Cambridge, MA 02142"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Chiang","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA 02215"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles N","family":"Serhan","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA 02215"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E","family":"Van Dyke","sequence":"additional","affiliation":[{"name":"The Forsyth Institute , Cambridge, MA 02142"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Gyurko","sequence":"additional","affiliation":[{"name":"Goldman School of Dental Medicine, Boston University , Boston, MA 02118"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,1,15]]},"reference":[{"key":"2025032406241175400_r1","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrd1383","article-title":"Inflammatory resolution: new opportunities for drug discovery","volume":"3","author":"Gilroy","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"key":"2025032406241175400_r2","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nri2294","article-title":"Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators","volume":"8","author":"Serhan","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"2025032406241175400_r3","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1084\/jem.192.8.1197","article-title":"Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing","volume":"192","author":"Serhan","year":"2000","journal-title":"J. Exp. Med."},{"key":"2025032406241175400_r4","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1084\/jem.20042031","article-title":"Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1","volume":"201","author":"Arita","year":"2005","journal-title":"J. Exp. Med."},{"key":"2025032406241175400_r5","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1172\/JCI42545","article-title":"Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation","volume":"121","author":"Oh","year":"2011","journal-title":"J. Clin. Invest."},{"key":"2025032406241175400_r6","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1096\/fj.05-4724fje","article-title":"RvE1 protects from local inflammation and osteoclast- mediated bone destruction in periodontitis","volume":"20","author":"Hasturk","year":"2006","journal-title":"FASEB J."},{"key":"2025032406241175400_r7","doi-asserted-by":"crossref","first-page":"7021","DOI":"10.4049\/jimmunol.179.10.7021","article-title":"Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo","volume":"179","author":"Hasturk","year":"2007","journal-title":"J. Immunol."},{"key":"2025032406241175400_r8","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1002\/(SICI)1521-4141(199805)28:05<1689::AID-IMMU1689>3.0.CO;2-I","article-title":"ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains","volume":"28","author":"Samson","year":"1998","journal-title":"Eur. J. Immunol."},{"key":"2025032406241175400_r9","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1084\/jem.20030382","article-title":"Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids","volume":"198","author":"Wittamer","year":"2003","journal-title":"J. Exp. Med."},{"key":"2025032406241175400_r10","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1359\/jbmr.091106","article-title":"Role of chemerin\/CMKLR1 signaling in adipogenesis and osteoblastogenesis of bone marrow stem cells","volume":"25","author":"Muruganandan","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"2025032406241175400_r11","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1006\/bbrc.1997.6455","article-title":"A novel G protein-coupled receptor with homology to neuropeptide and chemoattractant receptors expressed during bone development","volume":"233","author":"Methner","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2025032406241175400_r12","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/ajh.21170","article-title":"Identification of inflammatory and proresolving lipid mediators in bone marrow and their lipidomic profiles with ovariectomy and omega-3 intake","volume":"83","author":"Poulsen","year":"2008","journal-title":"Am. J. Hematol."},{"key":"2025032406241175400_r13","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1038\/bjp.2008.367","article-title":"An endogenous regulator of inflammation, resolvin E1, modulates osteoclast differentiation and bone resorption","volume":"155","author":"Herrera","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"2025032406241175400_r14","doi-asserted-by":"crossref","first-page":"7250","DOI":"10.4049\/jimmunol.177.10.7250","article-title":"Chronic hyperglycemia predisposes to exaggerated inflammatory response and leukocyte dysfunction in Akita mice","volume":"177","author":"Gyurko","year":"2006","journal-title":"J. Immunol."},{"key":"2025032406241175400_r15","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1600-051X.2007.01172.x","article-title":"The use of rodent models to investigate host-bacteria interactions related to periodontal diseases","volume":"35","author":"Graves","year":"2008","journal-title":"J. Clin. Periodontol."},{"key":"2025032406241175400_r16","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/jbmr.5650030406","article-title":"Further biochemical and molecular characterization of primary rat parietal bone cell cultures","volume":"3","author":"McCarthy","year":"1988","journal-title":"J. Bone Miner. Res."},{"key":"2025032406241175400_r17","doi-asserted-by":"crossref","first-page":"4345","DOI":"10.4049\/jimmunol.174.7.4345","article-title":"Molecular circuits of resolution: formation and actions of resolvins and protectins","volume":"174","author":"Bannenberg","year":"2005","journal-title":"J. Immunol."},{"key":"2025032406241175400_r18","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1373\/clinchem.2012.190199","article-title":"Resolvins D1, D2, and other mediators of self-limited resolution of inflammation in human blood following n-3 fatty acid supplementation","volume":"58","author":"Mas","year":"2012","journal-title":"Clin. Chem."},{"key":"2025032406241175400_r19","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.pharmtox.011008.145616","article-title":"Lipid mediators in health and disease: enzymes and receptors as therapeutic targets for the regulation of immunity and inflammation","volume":"49","author":"Shimizu","year":"2009","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"2025032406241175400_r20","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/nature05877","article-title":"Resolvin E1 and protectin D1 activate inflammation-resolution programmes","volume":"447","author":"Schwab","year":"2007","journal-title":"Nature"},{"key":"2025032406241175400_r21","doi-asserted-by":"crossref","first-page":"7671","DOI":"10.1073\/pnas.0409271102","article-title":"Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis","volume":"102","author":"Arita","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032406241175400_r22","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.cytogfr.2011.11.004","article-title":"Chemerin and its receptors in leukocyte trafficking, inflammation and metabolism","volume":"22","author":"Bondue","year":"2011","journal-title":"Cytokine Growth Factor Rev."},{"key":"2025032406241175400_r23","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.4049\/jimmunol.0902866","article-title":"A new strategy for the identification of novel molecules with targeted proresolution of inflammation properties","volume":"184","author":"Navarro-Xavier","year":"2010","journal-title":"J. Immunol."},{"key":"2025032406241175400_r24","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1074\/jbc.M109.044131","article-title":"Resolvin E1 receptor activation signals phosphorylation and phagocytosis","volume":"285","author":"Ohira","year":"2010","journal-title":"J. Biol. Chem."},{"key":"2025032406241175400_r25","doi-asserted-by":"crossref","first-page":"R228","DOI":"10.1186\/ar3215","article-title":"Human articular chondrocytes express ChemR23 and chemerin; ChemR23 promotes inflammatory signalling upon binding the ligand chemerin(21-157)","volume":"12","author":"Berg","year":"2010","journal-title":"Arthritis Res. Ther."},{"issue":"11","key":"2025032406241175400_r26","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1902\/jop.2005.76.11-S.2033","article-title":"Immune response: the key to bone resorption in periodontal disease","volume":"76","author":"Taubman","year":"2005","journal-title":"J. Periodontol."},{"key":"2025032406241175400_r27","doi-asserted-by":"crossref","DOI":"10.3402\/jom.v3i0.5304","article-title":"Review of osteoimmunology and the host response in endodontic and periodontal lesions","volume":"3","author":"Graves","year":"2011","journal-title":"J. Oral. Microbiol."},{"key":"2025032406241175400_r28","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1600-051X.2010.01662.x","article-title":"Proresolving lipid mediators: potential for prevention and treatment of periodontitis","volume":"38","author":"Van Dyke","year":"2011","journal-title":"J. Clin. Periodontol."},{"key":"2025032406241175400_r29","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.patbio.2008.06.004","article-title":"In vitro osteogenesis assays: influence of the primary cell source on alkaline phosphatase activity and mineralization","volume":"57","author":"Hoemann","year":"2009","journal-title":"Pathol. Biol. (Paris)"},{"key":"2025032406241175400_r30","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"key":"2025032406241175400_r31","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1600-051X.2011.01810.x","article-title":"The RANKL-OPG system in clinical periodontology","volume":"39","author":"Belibasakis","year":"2012","journal-title":"J. Clin. Periodontol."},{"key":"2025032406241175400_r32","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1359\/jbmr.1999.14.6.893","article-title":"Isolation and characterization of MC3T3-E1 preosteoblast subclones with distinct in vitro and in vivo differentiation\/mineralization potential","volume":"14","author":"Wang","year":"1999","journal-title":"J. Bone Miner. Res."},{"key":"2025032406241175400_r33","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/jbmr.5650070613","article-title":"Distinct proliferative and differentiated stages of murine MC3T3-E1 cells in culture: an in vitro model of osteoblast development","volume":"7","author":"Quarles","year":"1992","journal-title":"J. Bone Miner. Res."},{"key":"2025032406241175400_r34","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/nrd3669","article-title":"Inflammatory bone loss: pathogenesis and therapeutic intervention","volume":"11","author":"Redlich","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"key":"2025032406241175400_r35","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.0105-2896.2005.00338.x","article-title":"Rheumatic diseases: the effects of inflammation on bone","volume":"208","author":"Walsh","year":"2005","journal-title":"Immunol. Rev."},{"key":"2025032406241175400_r36","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1172\/JCI27071","article-title":"Pathogenesis of osteoporosis: concepts, conflicts, and prospects","volume":"115","author":"Raisz","year":"2005","journal-title":"J. Clin. Invest."},{"key":"2025032406241175400_r37","doi-asserted-by":"crossref","first-page":"410S","DOI":"10.1080\/07315724.2001.10719177","article-title":"Nutraceutical fatty acids as biochemical and molecular modulators of skeletal biology","volume":"20","author":"Watkins","year":"2001","journal-title":"J. Am. Coll. Nutr."},{"key":"2025032406241175400_r38","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.1210\/endo.139.7.6115","article-title":"5-Lipoxygenase metabolites inhibit bone formation in vitro","volume":"139","author":"Traianedes","year":"1998","journal-title":"Endocrinology"},{"key":"2025032406241175400_r39","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nm1591","article-title":"Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis","volume":"13","author":"Connor","year":"2007","journal-title":"Nat. Med."},{"key":"2025032406241175400_r40","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.intimp.2012.08.005","article-title":"Omega-3 fatty acid-derived mediator, Resolvin E1, ameliorates 2,4-dinitrofluorobenzene-induced atopic dermatitis in NC\/Nga mice","volume":"14","author":"Kim","year":"2012","journal-title":"Int. Immunopharmacol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/190\/2\/689\/62500176\/1103688.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/190\/2\/689\/62500176\/1103688.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:08:16Z","timestamp":1742947696000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/190\/2\/689\/8001321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,1,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1103688","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2013,1]]},"published":{"date-parts":[[2013,1]]}}}