{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T22:07:54Z","timestamp":1771798074141,"version":"3.50.1"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In addition to a well-documented role in regulating T cell-mediated immune responses, B7-H3, a newly discovered member of the B7 superfamily, has been recently identified as a costimulator in the innate immunity-mediated inflammatory response. In this study, we further report that B7-H3 participates in the development of pneumococcal meningitis in a murine model. Exogenous administration of B7-H3 strongly amplified the inflammatory response, exacerbated blood\u2013brain barrier disruption, and aggravated the clinical disease status in Streptococcus pneumoniae-infected C3H\/HeN wild-type mice. Consistent with the in vivo findings, B7-H3 substantially augmented proinflammatory cytokine and chemokine production, upregulated NF-\u03baB p65 and MAPK p38 phosphorylation, and enhanced the nuclear transactivation of NF-\u03baB p65 at both TNF-\u03b1 and IL-6 promoters in S. pneumoniae-stimulated primary murine microglia cells. These B7-H3\u2013associated in vitro and in vivo effects appeared to be dependent on TLR2 signaling, as B7-H3 almost completely lost its amplifying actions in both TLR2-deficient microglial cells and TLR2-deficient mice. Furthermore, administration of the anti\u2013B7-H3 mAb (MIH35) attenuated the inflammatory response and ameliorated blood\u2013brain barrier disruption in S. pneumoniae-infected wild-type mice. Collectively, our results indicate that B7-H3 plays a contributory role in the development of S. pneumoniae infection-induced bacterial meningitis.<\/jats:p>","DOI":"10.4049\/jimmunol.1103715","type":"journal-article","created":{"date-parts":[[2012,6,2]],"date-time":"2012-06-02T05:23:17Z","timestamp":1338614597000},"page":"347-355","source":"Crossref","is-referenced-by-count":38,"title":["B7-H3 Participates in the Development of Experimental Pneumococcal Meningitis by Augmentation of the Inflammatory Response via a TLR2-Dependent Mechanism"],"prefix":"10.1093","volume":"189","author":[{"given":"Xuqin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurology, Affiliated Children\u2019s Hospital, Soochow University , Suzhou 215006,","place":["People\u2019s Republic of China"]},{"name":"Department of Academic Surgery, University College Cork, Cork University Hospital , Cork,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edel M","family":"Quinn","sequence":"additional","affiliation":[{"name":"Department of Academic Surgery, University College Cork, Cork University Hospital , Cork,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Ni","sequence":"additional","affiliation":[{"name":"Neurology Laboratory, Affiliated Children\u2019s Hospital, Soochow University , Suzhou 215006,","place":["People\u2019s Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Affiliated Children\u2019s Hospital, Soochow University , Suzhou 215006,","place":["People\u2019s Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siobhan","family":"Blankson","sequence":"additional","affiliation":[{"name":"Department of Academic Surgery, University College Cork, Cork University Hospital , Cork,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H Paul","family":"Redmond","sequence":"additional","affiliation":[{"name":"Department of Academic Surgery, University College Cork, Cork University Hospital , Cork,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang Huai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Academic Surgery, University College Cork, Cork University Hospital , Cork,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Newborn Medicine, Affiliated Children\u2019s Hospital, Soochow University , Suzhou 215006,","place":["People\u2019s Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,7,1]]},"reference":[{"key":"2025032409161916500_r1","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1056\/NEJM199710023371404","article-title":"Bacterial meningitis in the United States in 1995","volume":"337","author":"Schuchat","year":"1997","journal-title":"N. 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