{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:14:40Z","timestamp":1789733680021,"version":"4.0.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>MHC class I and class II are crucial for the adaptive immune system. Although regulation of MHC class II expression by CIITA has long been recognized, the mechanism of MHC class I transactivation has been largely unknown until the recent discovery of NLRC5\/class I transactivator. In this study, we show using Nlrc5-deficient mice that NLRC5 is required for both constitutive and inducible MHC class I expression. Loss of Nlrc5 resulted in severe reduction in the expression of MHC class I and related genes such as \u03b22-microglobulin, Tap1, or Lmp2, but did not affect MHC class II levels. IFN-\u03b3 stimulation could not overcome the impaired MHC class I expression in Nlrc5-deficient cells. Upon infection with Listeria monocyogenes, Nlrc5-deficient mice displayed impaired CD8+ T cell activation, accompanied with increased bacterial loads. These findings illustrate critical roles of NLRC5\/class I transactivator in MHC class I gene regulation and host defense by CD8+ T cell responses.<\/jats:p>","DOI":"10.4049\/jimmunol.1200064","type":"journal-article","created":{"date-parts":[[2012,6,19]],"date-time":"2012-06-19T03:47:24Z","timestamp":1340077644000},"page":"516-520","source":"Crossref","is-referenced-by-count":102,"title":["Cutting Edge: Impaired MHC Class I Expression in Mice Deficient for Nlrc5\/Class I Transactivator"],"prefix":"10.1093","volume":"189","author":[{"given":"Amlan","family":"Biswas","sequence":"first","affiliation":[{"name":"Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute , Boston, MA 02215"},{"name":"Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School , Boston, MA 02215"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten B","family":"Meissner","sequence":"additional","affiliation":[{"name":"Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute , Boston, MA 02215"},{"name":"Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School , Boston, MA 02215"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Kawai","sequence":"additional","affiliation":[{"name":"Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Osaka University , Osaka 565-0871,","place":["Japan"]},{"name":"Department of Host Defense, Research Institute for Microbial Diseases, Osaka University , Osaka 565-0871,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi S","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute , Boston, MA 02215"},{"name":"Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School , Boston, MA 02215"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,7,15]]},"reference":[{"key":"2025032409211929700_r1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1146\/annurev.iy.11.040193.002155","article-title":"The biochemistry and cell biology of antigen processing and presentation","volume":"11","author":"Germain","year":"1993","journal-title":"Annu. 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