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The depressed Th17 response was closely associated with decreased numbers of a splenic dendritic cell (DC) subset expressing CD11c+CD3\u2212CD25+ and decreased expansion of \u03b3\u03b4 T cells. We demonstrated that ablation of the CD25+ DC subset accounted for the decreased activation and the expansion of \u03b3\u03b4 T cells, leading to decreased activation of IL-17+ interphotoreceptor retinoid-binding protein-specific T cells. Our results show that an enhanced Th17 response in an autoimmune disease is associated with the appearance of a DC subset expressing CD25 and that treatment of mice with anti-CD25 Ab causes functional alterations in a number of immune cell types, namely DCs and \u03b3\u03b4 T cells, in addition to CD25+\u03b1\u03b2TCR+ regulatory T cells.<\/jats:p>","DOI":"10.4049\/jimmunol.1200109","type":"journal-article","created":{"date-parts":[[2012,4,27]],"date-time":"2012-04-27T00:31:11Z","timestamp":1335486671000},"page":"5785-5791","source":"Crossref","is-referenced-by-count":34,"title":["Role of CD25+ Dendritic Cells in the Generation of Th17 Autoreactive T Cells in Autoimmune Experimental Uveitis"],"prefix":"10.1093","volume":"188","author":[{"given":"Dongchun","family":"Liang","sequence":"first","affiliation":[{"name":"Doheny Eye Institute, Keck School of Medicine of the University of Southern California , Los Angeles, CA 90033"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijun","family":"Zuo","sequence":"additional","affiliation":[{"name":"Doheny Eye Institute, Keck School of Medicine of the University of Southern California , Los Angeles, CA 90033"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville , Louisville, KY 40202"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willi K","family":"Born","sequence":"additional","affiliation":[{"name":"Integrated Department of Immunology, National Jewish Health Center , Denver, CO 80206"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Integrated Department of Immunology, National Jewish Health Center , Denver, CO 80206"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry J","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville , Louisville, KY 40202"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deming","family":"Sun","sequence":"additional","affiliation":[{"name":"Doheny Eye Institute, Keck School of Medicine of the University of Southern California , Los Angeles, CA 90033"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,6,1]]},"reference":[{"key":"2025032410114959800_r1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/292060a0","article-title":"Vaccination against autoimmune encephalomyelitis with T-lymphocyte line cells reactive against myelin basic protein","volume":"292","author":"Ben-Nun","year":"1981","journal-title":"Nature"},{"key":"2025032410114959800_r2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0092-8674(88)90558-2","article-title":"Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention","volume":"54","author":"Acha-Orbea","year":"1988","journal-title":"Cell"},{"key":"2025032410114959800_r3","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1146\/annurev.iy.07.040189.002103","article-title":"T cell receptors in murine autoimmune diseases","volume":"7","author":"Acha-Orbea","year":"1989","journal-title":"Annu. 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