{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T23:36:19Z","timestamp":1790465779147,"version":"4.1.0"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Clonal selection of a T cell for use in the immune response appears to necessitate proliferative expansion and terminal effector differentiation of some cellular progeny, while reserving other progeny as less-differentiated memory cells. It has been suggested that asymmetric cell division may promote initial cell diversification. Stem cell-like models of adaptive immunity might predict that subsequent encounters with a pathogen would evoke reiterative, self-renewing, asymmetric division by memory T cells. In this study, we show that murine memory CD8+ T cells can divide asymmetrically in response to secondary encounter with pathogen. Critical regulators of signaling and transcription are partitioned to one side of the mitotic spindle in rechallenged memory T cells, and two phenotypically distinct populations of daughter cells are evident from the earliest divisions. Memory T cells may thus use asymmetric cell division to generate cellular heterogeneity when faced with pathogen rechallenge.<\/jats:p>","DOI":"10.4049\/jimmunol.1200176","type":"journal-article","created":{"date-parts":[[2012,3,31]],"date-time":"2012-03-31T05:12:54Z","timestamp":1333170774000},"page":"4145-4148","source":"Crossref","is-referenced-by-count":75,"title":["Cutting Edge: Asymmetric Memory T Cell Division in Response to Rechallenge"],"prefix":"10.1093","volume":"188","author":[{"given":"Maria L","family":"Ciocca","sequence":"first","affiliation":[{"name":"Abramson Family Cancer Research Institute, University of Pennsylvania , Philadelphia, PA 19104"},{"name":"Department of Medicine, Perelman School of Medicine at the University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burton E","family":"Barnett","sequence":"additional","affiliation":[{"name":"Abramson Family Cancer Research Institute, University of Pennsylvania , Philadelphia, PA 19104"},{"name":"Department of Medicine, Perelman School of Medicine at the University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janis K","family":"Burkhardt","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania , Philadelphia, PA 19104"},{"name":"Children\u2019s Hospital of Philadelphia , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Diego , La Jolla, CA 92093"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven L","family":"Reiner","sequence":"additional","affiliation":[{"name":"Abramson Family Cancer Research Institute, University of Pennsylvania , Philadelphia, PA 19104"},{"name":"Department of Medicine, Perelman School of Medicine at the University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,5,1]]},"reference":[{"key":"2025032410045866200_r1","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.immuni.2007.10.012","article-title":"A single naive CD8+ T cell precursor can develop into diverse effector and memory subsets","volume":"27","author":"Stemberger","year":"2007","journal-title":"Immunity"},{"key":"2025032410045866200_r2","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1084\/jem.20072462","article-title":"Dissecting T cell lineage relationships by cellular barcoding","volume":"205","author":"Schepers","year":"2008","journal-title":"J. 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