{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T17:20:22Z","timestamp":1762017622439,"version":"3.40.3"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Group B streptococci (GBS; Streptococcus agalactiae) are a major cause of invasive infections in newborn infants and in patients with type 2 diabetes. Both patient groups exhibit peripheral insulin resistance and alterations in polymorphonuclear leukocyte (PML) function. In this investigation, we studied the PML response repertoire to GBS with a focus on TLR signaling and the modulation of this response by insulin in mice and humans. We found that GBS-induced, MyD88-dependent chemokine formation of PML was specifically downmodulated by insulin via insulin receptor-mediated induction of PI3K. PI3K inhibited transcription of chemokine genes on the level of NF-\u03baB activation and binding. Insulin specifically modulated the chemokine response of PML to whole bacteria, but affected neither activation by purified TLR agonists nor antimicrobial properties, such as migration, phagocytosis, bacterial killing, and formation of reactive oxygen species. The targeted modulation of bacteria-induced chemokine formation by insulin via PI3K may form a basis for the development of novel targets of adjunctive sepsis therapy.<\/jats:p>","DOI":"10.4049\/jimmunol.1200205","type":"journal-article","created":{"date-parts":[[2012,9,28]],"date-time":"2012-09-28T18:51:50Z","timestamp":1348858310000},"page":"4582-4591","source":"Crossref","is-referenced-by-count":10,"title":["Insulin Modulates the Inflammatory Granulocyte Response to Streptococci via Phosphatidylinositol 3-Kinase"],"prefix":"10.1093","volume":"189","author":[{"given":"Sybille","family":"Kenzel","sequence":"first","affiliation":[{"name":"Center for Pediatric and Adolescent Medicine, University of Freiburg , 79106 Freiburg,","place":["Germany"]},{"name":"Centre of Chronic Immunodeficiency, University Medical Center Freiburg , 79106 Freiburg,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Mergen","sequence":"additional","affiliation":[{"name":"Center for Pediatric and Adolescent Medicine, University of Freiburg , 79106 Freiburg,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julius","family":"von S\u00fc\u00dfkind-Schwendi","sequence":"additional","affiliation":[{"name":"Center for Pediatric and Adolescent Medicine, University of Freiburg , 79106 Freiburg,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Wennekamp","sequence":"additional","affiliation":[{"name":"Center for Pediatric and Adolescent Medicine, University of Freiburg , 79106 Freiburg,","place":["Germany"]},{"name":"Centre of Chronic Immunodeficiency, University Medical Center Freiburg , 79106 Freiburg,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachin D","family":"Deshmukh","sequence":"additional","affiliation":[{"name":"Centre of Chronic Immunodeficiency, University Medical Center Freiburg , 79106 Freiburg,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Haeffner","sequence":"additional","affiliation":[{"name":"Centre of Chronic Immunodeficiency, University Medical Center Freiburg , 79106 Freiburg,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antigoni","family":"Triantafyllopoulou","sequence":"additional","affiliation":[{"name":"Center for Pediatric and Adolescent Medicine, University of Freiburg , 79106 Freiburg,","place":["Germany"]},{"name":"Centre of Chronic Immunodeficiency, University Medical Center Freiburg , 79106 Freiburg,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Centre of Chronic Immunodeficiency, University Medical Center Freiburg , 79106 Freiburg,","place":["Germany"]},{"name":"Faculty of Biology, University of Freiburg , 79104 Freiburg,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Farmand","sequence":"additional","affiliation":[{"name":"Center for Pediatric and Adolescent Medicine, University of Freiburg , 79106 Freiburg,","place":["Germany"]},{"name":"Centre of Chronic Immunodeficiency, University Medical Center Freiburg , 79106 Freiburg,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Santos-Sierra","sequence":"additional","affiliation":[{"name":"Center for Pediatric and Adolescent Medicine, University of Freiburg , 79106 Freiburg,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Seufert","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetology, University of Freiburg , 79106 Freiburg,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo K","family":"van den Berg","sequence":"additional","affiliation":[{"name":"Sanquin Research Center and Landsteiner Laboratory , 1066 Amsterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taco W","family":"Kuijpers","sequence":"additional","affiliation":[{"name":"Emma Children\u2019s Hospital, Academic Medical Centre, University of Amsterdam , 1105 Amsterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Henneke","sequence":"additional","affiliation":[{"name":"Center for Pediatric and Adolescent Medicine, University of Freiburg , 79106 Freiburg,","place":["Germany"]},{"name":"Centre of Chronic Immunodeficiency, University Medical Center Freiburg , 79106 Freiburg,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,11,1]]},"reference":[{"key":"2025032409320458000_r1","doi-asserted-by":"crossref","first-page":"256","DOI":"10.2337\/diacare.15.2.256","article-title":"Impairment of polymorphonuclear leukocyte function and metabolic control of diabetes","volume":"15","author":"Marhoffer","year":"1992","journal-title":"Diabetes Care"},{"key":"2025032409320458000_r2","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/SHK.0b013e3181a85ec4","article-title":"Signaling pathways and mediators in LPS-induced lung inflammation in diabetic rats: role of insulin","volume":"33","author":"Martins","year":"2010","journal-title":"Shock"},{"key":"2025032409320458000_r3","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1097\/SHK.0b013e318186275e","article-title":"Insulin regulates cytokines and intercellular adhesion molecule-1 gene expression through nuclear factor-kappaB activation in LPS-induced acute lung injury in rats","volume":"31","author":"Martins","year":"2009","journal-title":"Shock"},{"key":"2025032409320458000_r4","doi-asserted-by":"crossref","first-page":"3632","DOI":"10.1128\/JCM.00531-11","article-title":"Clinical and molecular characteristics of invasive and noninvasive skin and soft tissue infections caused by group A Streptococcus","volume":"49","author":"Lin","year":"2011","journal-title":"J. Clin. Microbiol."},{"key":"2025032409320458000_r5","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3201\/eid1701.101174","article-title":"Concurrent conditions and human listeriosis, England, 1999\u20132009","volume":"17","author":"Mook","year":"2011","journal-title":"Emerg. Infect. Dis."},{"key":"2025032409320458000_r6","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jinf.2011.05.013","article-title":"Impact of diabetes and poor glycaemic control on risk of bacteraemia with haemolytic streptococci groups A, B, and G","volume":"63","author":"Thomsen","year":"2011","journal-title":"J. Infect."},{"key":"2025032409320458000_r7","first-page":"1","article-title":"Group B Streptococcus infection and diabetes: A review","volume":"4","author":"Yanai","year":"2012","journal-title":"J. Microbiol."},{"key":"2025032409320458000_r8","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.ijid.2008.10.007","article-title":"Invasive group B streptococcal infections in a tertiary care hospital between 1998 and 2007 in Japan","volume":"13","author":"Matsubara","year":"2009","journal-title":"Int. J. Infect. Dis."},{"key":"2025032409320458000_r9","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1542\/peds.2009-2959","article-title":"Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network","volume":"126","author":"Stoll","year":"2010","journal-title":"Pediatrics"},{"key":"2025032409320458000_r10","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1542\/peds.2010-2217","article-title":"Early onset neonatal sepsis: the burden of group B streptococcal and E. coli disease continues","volume":"127","author":"Stoll","year":"2011","journal-title":"Pediatrics"},{"key":"2025032409320458000_r11","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1086\/599369","article-title":"Increasing burden of invasive group B streptococcal disease in nonpregnant adults, 1990\u20132007","volume":"49","author":"Skoff","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"2025032409320458000_r12","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1097\/01.inf.0000237821.65559.08","article-title":"Serotypes, genotypes, and antibiotic susceptibility profiles of group B streptococci causing neonatal sepsis and meningitis before and after introduction of antibiotic prophylaxis","volume":"25","author":"Trijbels-Smeulders","year":"2006","journal-title":"Pediatr. Infect. Dis. J."},{"key":"2025032409320458000_r13","doi-asserted-by":"crossref","first-page":"e1139","DOI":"10.1542\/peds.2005-2481","article-title":"Incidence and clinical presentation of invasive neonatal group B streptococcal infections in Germany","volume":"117","author":"Fluegge","year":"2006","journal-title":"Pediatrics"},{"key":"2025032409320458000_r14","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1515\/jpm.2011.037","article-title":"Colonization, serotypes and transmission rates of group B streptococci in pregnant women and their infants born at a single University Center in Germany","volume":"39","author":"Kunze","year":"2011","journal-title":"J. Perinat. Med."},{"key":"2025032409320458000_r15","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.immuni.2005.11.011","article-title":"MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus","volume":"24","author":"Miller","year":"2006","journal-title":"Immunity"},{"key":"2025032409320458000_r16","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1365-2249.2008.03861.x","article-title":"Thermal injury induces impaired function in polymorphonuclear neutrophil granulocytes and reduced control of burn wound infection","volume":"156","author":"Calum","year":"2009","journal-title":"Clin. Exp. Immunol."},{"key":"2025032409320458000_r17","doi-asserted-by":"crossref","first-page":"7121","DOI":"10.4049\/jimmunol.181.10.7121","article-title":"A novel role for neutrophils as critical activators of NK cells","volume":"181","author":"Sp\u00f6rri","year":"2008","journal-title":"J. Immunol."},{"key":"2025032409320458000_r18","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.coph.2011.06.007","article-title":"The role of TLRs in neutrophil activation","volume":"11","author":"Prince","year":"2011","journal-title":"Curr. Opin. Pharmacol."},{"key":"2025032409320458000_r19","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1006\/mgme.2001.3185","article-title":"Impairment of type III group B Streptococcus-stimulated superoxide production and opsonophagocytosis by neutrophils in diabetes","volume":"73","author":"Mazade","year":"2001","journal-title":"Mol. Genet. Metab."},{"key":"2025032409320458000_r20","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1124\/jpet.108.138891","article-title":"Insulin activation of the phosphatidylinositol 3-kinase\/protein kinase B (Akt) pathway reduces lipopolysaccharide-induced inflammation in mice","volume":"326","author":"Kidd","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2025032409320458000_r21","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/01.CCM.0000045568.12881.10","article-title":"Outcome benefit of intensive insulin therapy in the critically ill: Insulin dose versus glycemic control","volume":"31","author":"Van den Berghe","year":"2003","journal-title":"Crit. Care Med."},{"key":"2025032409320458000_r22","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1164\/rccm.201002-0190OC","article-title":"Intensive insulin therapy in severely burned pediatric patients: a prospective randomized trial","volume":"182","author":"Jeschke","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2025032409320458000_r23","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0140-6736(09)60044-1","article-title":"Intensive insulin therapy for patients in paediatric intensive care: a prospective, randomised controlled study","volume":"373","author":"Vlasselaers","year":"2009","journal-title":"Lancet"},{"key":"2025032409320458000_r24","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.2337\/diabetes.55.04.06.db05-1434","article-title":"Survival benefits of intensive insulin therapy in critical illness: impact of maintaining normoglycemia versus glycemia-independent actions of insulin","volume":"55","author":"Ellger","year":"2006","journal-title":"Diabetes"},{"key":"2025032409320458000_r25","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1021\/bi00860a011","article-title":"Chemical, physical, biological properties of a lipopolysaccharide from Escherichia coli K-235","volume":"6","author":"McIntire","year":"1967","journal-title":"Biochemistry"},{"key":"2025032409320458000_r26","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1074-7613(00)80596-8","article-title":"Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function","volume":"9","author":"Adachi","year":"1998","journal-title":"Immunity"},{"key":"2025032409320458000_r27","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.4049\/jimmunol.176.5.3181","article-title":"c-Jun kinase is a critical signaling molecule in a neonatal model of group B streptococcal sepsis","volume":"176","author":"Kenzel","year":"2006","journal-title":"J. Immunol."},{"key":"2025032409320458000_r28","doi-asserted-by":"crossref","first-page":"7069","DOI":"10.4049\/jimmunol.167.12.7069","article-title":"Novel engagement of CD14 and multiple toll-like receptors by group B streptococci","volume":"167","author":"Henneke","year":"2001","journal-title":"J. Immunol."},{"key":"2025032409320458000_r29","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"2025032409320458000_r30","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1128\/IAI.01343-08","article-title":"Role of p38 and early growth response factor 1 in the macrophage response to group B streptococcus","volume":"77","author":"Kenzel","year":"2009","journal-title":"Infect. Immun."},{"key":"2025032409320458000_r31","doi-asserted-by":"crossref","first-page":"6324","DOI":"10.4049\/jimmunol.172.10.6324","article-title":"Dual role of TLR2 and myeloid differentiation factor 88 in a mouse model of invasive group B streptococcal disease","volume":"172","author":"Mancuso","year":"2004","journal-title":"J. Immunol."},{"key":"2025032409320458000_r32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/embor.2010.189","article-title":"Macrophages recognize streptococci through bacterial single-stranded RNA","volume":"12","author":"Deshmukh","year":"2011","journal-title":"EMBO Rep."},{"key":"2025032409320458000_r33","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1128\/IAI.01551-05","article-title":"Interaction of neonatal phagocytes with group B streptococcus: recognition and response","volume":"74","author":"Henneke","year":"2006","journal-title":"Infect. Immun."},{"key":"2025032409320458000_r34","doi-asserted-by":"crossref","first-page":"7071","DOI":"10.4049\/jimmunol.1000110","article-title":"Phagocytosis and phagosome acidification are required for pathogen processing and MyD88-dependent responses to Staphylococcus aureus","volume":"184","author":"Ip","year":"2010","journal-title":"J. Immunol."},{"key":"2025032409320458000_r35","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1128\/IAI.01138-09","article-title":"Toll-like receptor 2- and MyD88-dependent phosphatidylinositol 3-kinase and Rac1 activation facilitates the phagocytosis of Listeria monocytogenes by murine macrophages","volume":"78","author":"Shen","year":"2010","journal-title":"Infect. Immun."},{"key":"2025032409320458000_r36","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.humimm.2006.05.004","article-title":"Crosslinking of CD66B on peripheral blood neutrophils mediates the release of interleukin-8 from intracellular storage","volume":"67","author":"Schr\u00f6der","year":"2006","journal-title":"Hum. Immunol."},{"key":"2025032409320458000_r37","doi-asserted-by":"crossref","first-page":"153","DOI":"10.4049\/jimmunol.153.1.153","article-title":"Synergistic transcriptional activation of the IL-8 gene by NF-kappa B p65 (RelA) and NF-IL-6","volume":"153","author":"Kunsch","year":"1994","journal-title":"J. Immunol."},{"key":"2025032409320458000_r38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4049\/jimmunol.163.1.1","article-title":"Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2","volume":"163","author":"Yoshimura","year":"1999","journal-title":"J. Immunol."},{"key":"2025032409320458000_r39","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1167\/iovs.06-0081","article-title":"Transcriptional regulation of IL-8 by Staphylococcus aureus in human conjunctival cells involves activation of AP-1","volume":"48","author":"Venza","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2025032409320458000_r40","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/82797","article-title":"Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway","volume":"1","author":"Arbibe","year":"2000","journal-title":"Nat. Immunol."},{"key":"2025032409320458000_r41","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1038\/emboj.2009.158","article-title":"Mal connects TLR2 to PI3Kinase activation and phagocyte polarization","volume":"28","author":"Santos-Sierra","year":"2009","journal-title":"EMBO J."},{"key":"2025032409320458000_r42","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1097\/01.fjc.0000188365.07635.57","article-title":"Pioglitazone mimics preconditioning in the isolated perfused rat heart: a role for the prosurvival kinases PI3K and P42\/44MAPK","volume":"46","author":"Wynne","year":"2005","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"2025032409320458000_r43","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.lfs.2008.09.002","article-title":"Pioglitazone acutely stimulates adiponectin secretion from mouse and human adipocytes via activation of the phosphatidylinositol 3\u2032-kinase","volume":"83","author":"Pereira","year":"2008","journal-title":"Life Sci."},{"key":"2025032409320458000_r44","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/01.qco.0000224821.27482.bd","article-title":"The innate immune system and its relevance to neonatal sepsis","volume":"19","author":"Kenzel","year":"2006","journal-title":"Curr. Opin. Infect. Dis."},{"key":"2025032409320458000_r45","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1600-065X.2008.00673.x","article-title":"Induction and termination of inflammatory signaling in group B streptococcal sepsis","volume":"225","author":"Wennekamp","year":"2008","journal-title":"Immunol. Rev."},{"key":"2025032409320458000_r46","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00109-010-0677-3","article-title":"Tailor-made inflammation: how neutrophil serine proteases modulate the inflammatory response","volume":"89","author":"Kessenbrock","year":"2011","journal-title":"J. Mol. Med."},{"key":"2025032409320458000_r47","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.4049\/jimmunol.176.2.1195","article-title":"Activation of TLR-9 induces IL-8 secretion through peroxynitrite signaling in human neutrophils","volume":"176","author":"J\u00f3zsef","year":"2006","journal-title":"J. Immunol."},{"key":"2025032409320458000_r48","doi-asserted-by":"crossref","first-page":"391","DOI":"10.4049\/jimmunol.0900564","article-title":"Phagocytosis of apoptotic cells by neutrophil granulocytes: diminished proinflammatory neutrophil functions in the presence of apoptotic cells","volume":"184","author":"Esmann","year":"2010","journal-title":"J. Immunol."},{"key":"2025032409320458000_r49","doi-asserted-by":"crossref","first-page":"ra23","DOI":"10.1126\/scisignal.2001617","article-title":"PI3K\u03b2 plays a critical role in neutrophil activation by immune complexes","volume":"4","author":"Kulkarni","year":"2011","journal-title":"Sci. Signal."},{"key":"2025032409320458000_r50","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.4049\/jimmunol.180.4.2054","article-title":"Critical roles of the p110 beta subtype of phosphoinositide 3-kinase in lipopolysaccharide-induced Akt activation and negative regulation of nitrite production in RAW 264.7 cells","volume":"180","author":"Tsukamoto","year":"2008","journal-title":"J. Immunol."},{"key":"2025032409320458000_r51","doi-asserted-by":"crossref","first-page":"6194","DOI":"10.4049\/jimmunol.176.10.6194","article-title":"TLR5-mediated phosphoinositide 3-kinase activation negatively regulates flagellin-induced proinflammatory gene expression","volume":"176","author":"Yu","year":"2006","journal-title":"J. Immunol."},{"key":"2025032409320458000_r52","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1248\/bpb.30.1617","article-title":"Role of phosphoinositide 3-kinase in innate immunity","volume":"30","author":"Hazeki","year":"2007","journal-title":"Biol. Pharm. Bull."},{"key":"2025032409320458000_r53","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s11373-007-9150-x","article-title":"A20 attenuates vascular smooth muscle cell proliferation and migration through blocking PI3k\/Akt singling in vitro and in vivo","volume":"14","author":"Wang","year":"2007","journal-title":"J. Biomed. Sci."},{"key":"2025032409320458000_r54","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/ni.2043","article-title":"Tumor necrosis factor induces GSK3 kinase-mediated cross-tolerance to endotoxin in macrophages","volume":"12","author":"Park","year":"2011","journal-title":"Nat. Immunol."},{"key":"2025032409320458000_r55","doi-asserted-by":"crossref","first-page":"49205","DOI":"10.1074\/jbc.M209685200","article-title":"Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1\/ST2. A role for Jun N-terminal kinase in IL-4 induction","volume":"277","author":"Brint","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2025032409320458000_r56","doi-asserted-by":"crossref","first-page":"32124","DOI":"10.1074\/jbc.M203298200","article-title":"The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells","volume":"277","author":"Guha","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2025032409320458000_r57","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/ibd.21097","article-title":"TLR5 is not required for flagellin-mediated exacerbation of DSS colitis","volume":"16","author":"Ivison","year":"2010","journal-title":"Inflamm. Bowel Dis."},{"key":"2025032409320458000_r58","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1016\/j.molimm.2009.03.010","article-title":"Role of phosphoinositide 3-kinase p110 delta in TLR4- and TLR9-mediated B cell cytokine production and differentiation","volume":"46","author":"Dil","year":"2009","journal-title":"Mol. Immunol."},{"key":"2025032409320458000_r59","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1002\/eji.201040945","article-title":"A class IA PI3K controls inflammatory cytokine production in human neutrophils","volume":"41","author":"Fortin","year":"2011","journal-title":"Eur. J. Immunol."},{"key":"2025032409320458000_r60","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1182\/blood-2007-11-121723","article-title":"Hyperglycemia enhances coagulation and reduces neutrophil degranulation, whereas hyperinsulinemia inhibits fibrinolysis during human endotoxemia","volume":"112","author":"Stegenga","year":"2008","journal-title":"Blood"},{"key":"2025032409320458000_r61","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/0026-0495(86)90208-8","article-title":"The influence of plasma insulin concentrations on tissue insulin levels in rodents: a study of the diabetic Chinese hamster and the ob\/ob mouse","volume":"35","author":"Agardh","year":"1986","journal-title":"Metabolism"},{"key":"2025032409320458000_r62","doi-asserted-by":"crossref","first-page":"510","DOI":"10.2337\/diacare.26.2.510","article-title":"Quantifying the risk of infectious diseases for people with diabetes","volume":"26","author":"Shah","year":"2003","journal-title":"Diabetes Care"},{"key":"2025032409320458000_r63","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s005920050147","article-title":"Circulating levels of interleukin-6, its soluble receptor and interleukin-6\/interleukin-6 receptor complexes in patients with type 2 diabetes mellitus","volume":"36","author":"Kado","year":"1999","journal-title":"Acta Diabetol."},{"key":"2025032409320458000_r64","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1056\/NEJMoa052521","article-title":"Intensive insulin therapy in the medical ICU","volume":"354","author":"Van den Berghe","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"2025032409320458000_r65","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1056\/NEJMoa011300","article-title":"Intensive insulin therapy in critically ill patients","volume":"345","author":"van den Berghe","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"2025032409320458000_r66","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1007\/s00134-004-2210-z","article-title":"Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock","volume":"30","author":"Dellinger","year":"2004","journal-title":"Intensive Care Med."},{"key":"2025032409320458000_r67","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1001\/jama.290.15.2041","article-title":"Glucose control and mortality in critically ill patients","volume":"290","author":"Finney","year":"2003","journal-title":"JAMA"},{"issue":"9","key":"2025032409320458000_r68","doi-asserted-by":"crossref","first-page":"S503","DOI":"10.1097\/01.CCM.0000278046.24345.C7","article-title":"Clinical experience with tight glucose control by intensive insulin therapy","volume":"35","author":"Preiser","year":"2007","journal-title":"Crit. Care Med."},{"key":"2025032409320458000_r69","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s12028-010-9417-3","article-title":"Intensive versus conventional insulin therapy in critically ill neurologic patients","volume":"13","author":"Green","year":"2010","journal-title":"Neurocrit. Care"},{"key":"2025032409320458000_r70","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1097\/PCC.0b013e318207097e","article-title":"A critical appraisal of Vlasselaers D, Milants I, Desmet L, et al: intensive insulin therapy for patients in paediatric intensive care: a prospective, randomized controlled study. Lancet 2009; 373:547\u2013556","volume":"12","author":"Ulate","year":"2011","journal-title":"Pediatr. Crit. Care Med."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/189\/9\/4582\/62480802\/1200205.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/189\/9\/4582\/62480802\/1200205.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T08:05:05Z","timestamp":1743062705000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/189\/9\/4582\/7997758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,1]]},"references-count":70,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,11,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1200205","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"type":"print","value":"0022-1767"},{"type":"electronic","value":"1550-6606"}],"subject":[],"published-other":{"date-parts":[[2012,11]]},"published":{"date-parts":[[2012,11,1]]}}}