{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T04:44:00Z","timestamp":1766551440826,"version":"3.40.3"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The maintenance of adequate serum Ab levels following immunization has been identified as the most important mechanism for individual long-term protection against rapidly invading encapsulated bacteria. The mechanisms for maintaining adequate serum Ab levels and the relationship between Ag-specific memory B cells and Ab at steady state are poorly understood. We measured the frequency of circulating serogroup C meningococcal (MenC)-specific memory B cells in 250 healthy 6- to 12-y-old children 6 y following MenC conjugate vaccine priming, before a booster of a combined Haemophilus influenzae type b\u2013MenC conjugate vaccine and then 1 wk, 1 mo, and 1 y after the booster. We investigated the relationship between circulating MenC-specific memory B cell frequencies and Ab at baseline and following the booster vaccine. We found very low frequencies of circulating MenC-specific memory B cells at steady state in primary school-aged children and little association with MenC IgG Ab levels. Following vaccination, there were robust memory B cell booster responses that, unlike Ab levels, were not dependent on age at priming with MenC. Measurement of B cell memory in peripheral blood does not predict steady state Ab levels nor the capacity to respond to a booster dose of MenC Ag.<\/jats:p>","DOI":"10.4049\/jimmunol.1200451","type":"journal-article","created":{"date-parts":[[2012,8,2]],"date-time":"2012-08-02T00:52:02Z","timestamp":1343868722000},"page":"2673-2681","source":"Crossref","is-referenced-by-count":20,"title":["B Cell Memory to a Serogroup C Meningococcal Conjugate Vaccine in Childhood and Response to Booster: Little Association with Serum IgG Antibody"],"prefix":"10.1093","volume":"189","author":[{"given":"Kirsten P","family":"Perrett","sequence":"first","affiliation":[{"name":"Oxford Vaccine Group, Department of Paediatrics, University of Oxford , Oxford OX3 7LE,","place":["United Kingdom"]},{"name":"National Institute for Health Research, Oxford Biomedical Research Centre , Oxford OX3 7LE,","place":["United Kingdom"]},{"name":"Department of Paediatrics, University of Melbourne and Murdoch Children\u2019s Research Institute, Royal Children\u2019s Hospital Melbourne , Parkville, Victoria 3052,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celina","family":"Jin","sequence":"additional","affiliation":[{"name":"Oxford Vaccine Group, Department of Paediatrics, University of Oxford , Oxford OX3 7LE,","place":["United Kingdom"]},{"name":"National Institute for Health Research, Oxford Biomedical Research Centre , Oxford OX3 7LE,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Clutterbuck","sequence":"additional","affiliation":[{"name":"Oxford Vaccine Group, Department of Paediatrics, University of Oxford , Oxford OX3 7LE,","place":["United Kingdom"]},{"name":"National Institute for Health Research, Oxford Biomedical Research Centre , Oxford OX3 7LE,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tessa M","family":"John","sequence":"additional","affiliation":[{"name":"Oxford Vaccine Group, Department of Paediatrics, University of Oxford , Oxford OX3 7LE,","place":["United Kingdom"]},{"name":"National Institute for Health Research, Oxford Biomedical Research Centre , Oxford OX3 7LE,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy P","family":"Winter","sequence":"additional","affiliation":[{"name":"Oxford Vaccine Group, Department of Paediatrics, University of Oxford , Oxford OX3 7LE,","place":["United Kingdom"]},{"name":"National Institute for Health Research, Oxford Biomedical Research Centre , Oxford OX3 7LE,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Kibwana","sequence":"additional","affiliation":[{"name":"Oxford Vaccine Group, Department of Paediatrics, University of Oxford , Oxford OX3 7LE,","place":["United Kingdom"]},{"name":"National Institute for Health Research, Oxford Biomedical Research Centre , Oxford OX3 7LE,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ly-Mee","family":"Yu","sequence":"additional","affiliation":[{"name":"Centre for Statistics in Medicine, University of Oxford , Oxford OX2 6UD,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nigel","family":"Curtis","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University of Melbourne and Murdoch Children\u2019s Research Institute, Royal Children\u2019s Hospital Melbourne , Parkville, Victoria 3052,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J","family":"Pollard","sequence":"additional","affiliation":[{"name":"Oxford Vaccine Group, Department of Paediatrics, University of Oxford , Oxford OX3 7LE,","place":["United Kingdom"]},{"name":"National Institute for Health Research, Oxford Biomedical Research Centre , Oxford OX3 7LE,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,9,1]]},"reference":[{"key":"2025032409230158800_r1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1574-6976.2006.00059.x","article-title":"Diagnosis and management of meningococcal disease: the need for centralized care","volume":"31","author":"Nadel","year":"2007","journal-title":"FEMS Microbiol. 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