{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T18:20:39Z","timestamp":1780078839219,"version":"3.54.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>CD8+ T cells undergo rapid expansion during infection with intracellular pathogens, which is followed by swift and massive culling of primed CD8+ T cells. The mechanisms that govern the massive contraction and maintenance of primed CD8+ T cells are not clear. We show in this study that the transcription factor, FoxO3a, does not influence Ag presentation and the consequent expansion of CD8+ T cell response during Listeria monocytogenes infection, but plays a key role in the maintenance of memory CD8+ T cells. The effector function of primed CD8+ T cells as revealed by cytokine secretion and CD107a degranulation was not influenced by inactivation of FoxO3a. Interestingly, FoxO3a-deficient CD8+ T cells displayed reduced expression of proapoptotic molecules BIM and PUMA during the various phases of response, and underwent reduced apoptosis in comparison with wild-type cells. A higher number of memory precursor effector cells and memory subsets was detectable in FoxO3a-deficient mice compared with wild-type mice. Furthermore, FoxO3a-deficient memory CD8+ T cells upon transfer into normal or RAG1-deficient mice displayed enhanced survival. These results suggest that FoxO3a acts in a cell-intrinsic manner to regulate the survival of primed CD8+ T cells.<\/jats:p>","DOI":"10.4049\/jimmunol.1200639","type":"journal-article","created":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T02:47:15Z","timestamp":1357008435000},"page":"1066-1075","source":"Crossref","is-referenced-by-count":29,"title":["Intrinsic Role of FoxO3a in the Development of CD8+ T Cell Memory"],"prefix":"10.1093","volume":"190","author":[{"given":"Fanny","family":"Tzelepis","sequence":"first","affiliation":[{"name":"National Research Council of Canada, Institute for Biological Sciences , Ottawa, Ontario K1A 0R6,","place":["Canada"]},{"name":"Department of Biochemistry, Microbiology and Immunology, University of Ottawa , Ontario K1H 8M5,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Joseph","sequence":"additional","affiliation":[{"name":"National Research Council of Canada, Institute for Biological Sciences , Ottawa, Ontario K1A 0R6,","place":["Canada"]},{"name":"Department of Biochemistry, Microbiology and Immunology, University of Ottawa , Ontario K1H 8M5,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias K","family":"Haddad","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute , Port St. Lucie, FL 34987"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"MacLean","sequence":"additional","affiliation":[{"name":"National Research Council of Canada, Institute for Biological Sciences , Ottawa, Ontario K1A 0R6,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renu","family":"Dudani","sequence":"additional","affiliation":[{"name":"National Research Council of Canada, Institute for Biological Sciences , Ottawa, Ontario K1A 0R6,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Agenes","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, INSERM U743, University of Montreal , Quebec H3C 3J7,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanford L","family":"Peng","sequence":"additional","affiliation":[{"name":"Virginia Mason Medical Center , Seattle, WA 98101"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafick-Pierre","family":"Sekaly","sequence":"additional","affiliation":[{"name":"Virginia Mason Medical Center , Seattle, WA 98101"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subash","family":"Sad","sequence":"additional","affiliation":[{"name":"National Research Council of Canada, Institute for Biological Sciences , Ottawa, Ontario K1A 0R6,","place":["Canada"]},{"name":"Department of Biochemistry, Microbiology and Immunology, University of Ottawa , Ontario K1H 8M5,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,2,1]]},"reference":[{"key":"2025032406294329800_r1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nri778","article-title":"Effector and memory T-cell differentiation: implications for vaccine development","volume":"2","author":"Kaech","year":"2002","journal-title":"Nat. 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