{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:42:02Z","timestamp":1790674922298,"version":"4.1.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The side effects of current immunosuppressive drugs have impeded the development of therapies for immune diseases. Selective regulation of STAT signaling is an attractive strategy for treating immune disorders. In this study, we used a small-molecule compound to explore possible means of targeting STAT1 for the treatment of Th1-mediated inflammation. Selective regulation of STAT1 signaling in T cells from C57BL\/6 mice was accomplished using fusaruside, a small-molecule compound that triggers the tyrosine phosphorylation of Src homology 2-containing protein tyrosine phosphatase 2 (SHP-2). The interaction of tyrosine phosphorylated SHP-2 (pY-SHP-2) with cytosolic STAT1 prevented the recruitment of STAT1 to IFN-\u03b3R and specifically inhibited STAT1 signaling, resulting in a reduction in Th1 cytokine production and an improvement in 2, 4, 6-trinitrobenzene sulfonic acid-induced colitis in mice. Blocking the pY-SHP-2\u2013STAT1 interaction, with SHP-2 inhibitor NSC-87877 or using T cells from conditional SHP-2 knockout mice, reversed the effects of fusaruside, resulting in STAT1 activation and worsened colitis. The fusaruside-induced ability of pY-SHP-2 to selectively sequestrate STAT1 from recruitment to the receptor is independent of its function as a phosphatase, demonstrating a novel role for SHP-2 in regulating both STAT1 signaling and Th1-type immune responses. These findings could lead to increased options for the treatment of Crohn\u2019s disease and other Th1-mediated inflammatory diseases.<\/jats:p>","DOI":"10.4049\/jimmunol.1201006","type":"journal-article","created":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T20:43:04Z","timestamp":1346532184000},"page":"3497-3507","source":"Crossref","is-referenced-by-count":58,"title":["Selective Sequestration of STAT1 in the Cytoplasm via Phosphorylated SHP-2 Ameliorates Murine Experimental Colitis"],"prefix":"10.1093","volume":"189","author":[{"given":"Xingxin","family":"Wu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University , Nanjing 210093,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University , Nanjing 210093,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limei","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University , Nanjing 210093,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, First Affiliated Hospital of Nanjing Medical University , Nanjing 210029,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyun","family":"Gu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University , Nanjing 210093,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhai","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University , Nanjing 210093,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University , Nanjing 210093,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Shen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University , Nanjing 210093,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehai","family":"Ke","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Signaling and Modeling Genetics, Department of Basic Medical Sciences, Institute of Molecular Pathology, School of Medicine, Zhejiang University , Hangzhou 310058,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renxiang","family":"Tan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University , Nanjing 210093,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University , Nanjing 210093,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University , Nanjing 210093,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,10,1]]},"reference":[{"key":"2025032409274619300_r1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1157\/13090382","article-title":"[Cytokines in the pathogenesis of inflammatory bowel diseases]","volume":"127","author":"Jos\u00e9 Le\u00f3n","year":"2006","journal-title":"Med. Clin. (Barc.)"},{"key":"2025032409274619300_r2","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.2353\/ajpath.2008.080444","article-title":"Hyaluronan-mediated leukocyte adhesion and dextran sulfate sodium-induced colitis are attenuated in the absence of signal transducer and activator of transcription 1","volume":"173","author":"Bandyopadhyay","year":"2008","journal-title":"Am. J. Pathol."},{"key":"2025032409274619300_r3","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1084\/jem.20011956","article-title":"The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn\u2019s disease","volume":"195","author":"Neurath","year":"2002","journal-title":"J. Exp. Med."},{"key":"2025032409274619300_r4","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1172\/JCI0215644","article-title":"Series introduction. JAK-STAT signaling in human disease","volume":"109","author":"Schindler","year":"2002","journal-title":"J. Clin. Invest."},{"key":"2025032409274619300_r5","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/nrd1441","article-title":"A new modality for immunosuppression: targeting the JAK\/STAT pathway","volume":"3","author":"O\u2019Shea","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"key":"2025032409274619300_r6","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.exphem.2006.02.014","article-title":"Reduction of graft-versus-host disease by histone deacetylase inhibitor suberonylanilide hydroxamic acid is associated with modulation of inflammatory cytokine milieu and involves inhibition of STAT1","volume":"34","author":"Leng","year":"2006","journal-title":"Exp. Hematol."},{"key":"2025032409274619300_r7","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/7445","article-title":"Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling","volume":"5","author":"Frank","year":"1999","journal-title":"Nat. Med."},{"key":"2025032409274619300_r8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cyto.2003.09.006","article-title":"Implication of STAT1 and STAT3 transcription factors in the response to superantigens","volume":"25","author":"Plaza","year":"2004","journal-title":"Cytokine"},{"key":"2025032409274619300_r9","doi-asserted-by":"crossref","first-page":"33637","DOI":"10.1074\/jbc.M301053200","article-title":"Stimulation of signal transducer and activator of transcription-1 (STAT1)-dependent gene transcription by lipopolysaccharide and interferon-gamma is regulated by mammalian target of rapamycin","volume":"278","author":"Kristof","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2025032409274619300_r10","doi-asserted-by":"crossref","first-page":"4833","DOI":"10.4049\/jimmunol.170.9.4833","article-title":"Inhibition of IFN-gamma signaling by glucocorticoids","volume":"170","author":"Hu","year":"2003","journal-title":"J. Immunol."},{"key":"2025032409274619300_r11","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.molimm.2009.07.030","article-title":"Decreased STAT-1 phosphorylation by a thio analogue of beta-D-glucosylceramide is associated with altered NKT lymphocyte polarization","volume":"47","author":"Ben Ya\u2019acov","year":"2009","journal-title":"Mol. Immunol."},{"key":"2025032409274619300_r12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/sj.leu.2401657","article-title":"Serine\/threonine phosphorylation in cytokine signal transduction","volume":"14","author":"McCubrey","year":"2000","journal-title":"Leukemia"},{"key":"2025032409274619300_r13","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1074\/jbc.M405204200","article-title":"Interleukin-12-induced interferon-gamma production by human peripheral blood T cells is regulated by mammalian target of rapamycin (mTOR)","volume":"280","author":"Kusaba","year":"2005","journal-title":"J. Biol. Chem."},{"key":"2025032409274619300_r14","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.1074\/jbc.M108598200","article-title":"Identification of novel targets of immunosuppressive agents by cDNA-based microarray analysis","volume":"277","author":"Cristillo","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2025032409274619300_r15","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0022-3565(24)29246-6","article-title":"Prodigiosin blocks T cell activation by inhibiting interleukin-2Ralpha expression and delays progression of autoimmune diabetes and collagen-induced arthritis","volume":"299","author":"Han","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2025032409274619300_r16","doi-asserted-by":"crossref","first-page":"4582","DOI":"10.4049\/jimmunol.155.10.4582","article-title":"Activation of the signal transducer and transcription (STAT) signaling pathway in a primary T cell response. Critical role for IL-6","volume":"155","author":"Henttinen","year":"1995","journal-title":"J. Immunol."},{"key":"2025032409274619300_r17","doi-asserted-by":"crossref","first-page":"9573","DOI":"10.1073\/pnas.160099797","article-title":"Inhibition of IL-2-induced Jak-STAT signaling by glucocorticoids","volume":"97","author":"Bianchi","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032409274619300_r18","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.4049\/jimmunol.164.4.1768","article-title":"Inhibition of Th1 immune response by glucocorticoids: dexamethasone selectively inhibits IL-12-induced Stat4 phosphorylation in T lymphocytes","volume":"164","author":"Franchimont","year":"2000","journal-title":"J. Immunol."},{"key":"2025032409274619300_r19","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1136\/gut.2006.095497","article-title":"Beta-glucosylceramide: a novel method for enhancement of natural killer T lymphocyte plasticity in murine models of immune-mediated disorders","volume":"56","author":"Zigmond","year":"2007","journal-title":"Gut"},{"key":"2025032409274619300_r20","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S1074-7613(00)00077-7","article-title":"Immune response in Stat2 knockout mice","volume":"13","author":"Park","year":"2000","journal-title":"Immunity"},{"key":"2025032409274619300_r21","doi-asserted-by":"crossref","first-page":"7880","DOI":"10.4049\/jimmunol.177.11.7880","article-title":"General nature of the STAT3-activated anti-inflammatory response","volume":"177","author":"El Kasmi","year":"2006","journal-title":"J. Immunol."},{"key":"2025032409274619300_r22","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1074-7613(00)80005-9","article-title":"Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils","volume":"10","author":"Takeda","year":"1999","journal-title":"Immunity"},{"key":"2025032409274619300_r23","first-page":"92","article-title":"Cytokines, STATs and liver disease","volume":"2","author":"Gao","year":"2005","journal-title":"Cell. Mol. Immunol."},{"key":"2025032409274619300_r24","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1172\/JCI0215786","article-title":"JAK-STAT signaling in asthma","volume":"109","author":"Pernis","year":"2002","journal-title":"J. Clin. Invest."},{"key":"2025032409274619300_r25","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1097\/01.MIB.0000182871.76434.57","article-title":"DSS-induced colitis is exacerbated in STAT-6 knockout mice","volume":"11","author":"Elrod","year":"2005","journal-title":"Inflamm. Bowel Dis."},{"key":"2025032409274619300_r26","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1080\/003655200750023787","article-title":"The effect of dexamethasone treatment on murine colitis","volume":"35","author":"van Meeteren","year":"2000","journal-title":"Scand. J. Gastroenterol."},{"key":"2025032409274619300_r27","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1128\/MCB.19.3.2416","article-title":"Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak\/STAT pathway","volume":"19","author":"You","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"2025032409274619300_r28","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.immuni.2006.10.014","article-title":"SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production","volume":"25","author":"An","year":"2006","journal-title":"Immunity"},{"key":"2025032409274619300_r29","doi-asserted-by":"crossref","first-page":"6072","DOI":"10.4049\/jimmunol.171.11.6072","article-title":"Curcumin suppresses Janus kinase-STAT inflammatory signaling through activation of Src homology 2 domain-containing tyrosine phosphatase 2 in brain microglia","volume":"171","author":"Kim","year":"2003","journal-title":"J. Immunol."},{"key":"2025032409274619300_r30","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1182\/blood-2006-07-028829","article-title":"PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase","volume":"109","author":"Chan","year":"2007","journal-title":"Blood"},{"key":"2025032409274619300_r31","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1086\/499925","article-title":"Diversity and functional consequences of germline and somatic PTPN11 mutations in human disease","volume":"78","author":"Tartaglia","year":"2006","journal-title":"Am. J. Hum. Genet."},{"key":"2025032409274619300_r32","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.ccr.2011.03.023","article-title":"Ptpn11\/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis","volume":"19","author":"Bard-Chapeau","year":"2011","journal-title":"Cancer Cell"},{"key":"2025032409274619300_r33","doi-asserted-by":"crossref","first-page":"47572","DOI":"10.1074\/jbc.M207536200","article-title":"SHP-2 is a dual-specificity phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues in nuclei","volume":"277","author":"Wu","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2025032409274619300_r34","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1074\/jbc.275.1.599","article-title":"Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulation","volume":"275","author":"Yu","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2025032409274619300_r35","doi-asserted-by":"crossref","first-page":"5995","DOI":"10.1038\/sj.onc.1206846","article-title":"Catalytic-dependent and -independent roles of SHP-2 tyrosine phosphatase in interleukin-3 signaling","volume":"22","author":"Yu","year":"2003","journal-title":"Oncogene"},{"key":"2025032409274619300_r36","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.devcel.2010.03.009","article-title":"Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis","volume":"18","author":"Stewart","year":"2010","journal-title":"Dev. Cell"},{"key":"2025032409274619300_r37","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s11745-004-1280-9","article-title":"Antibacterial and xanthine oxidase inhibitory cerebrosides from Fusarium sp. IFB-121, an endophytic fungus in Quercus variabilis","volume":"39","author":"Shu","year":"2004","journal-title":"Lipids"},{"key":"2025032409274619300_r38","doi-asserted-by":"crossref","first-page":"6861","DOI":"10.1073\/pnas.89.15.6861","article-title":"Tissue- and site-specific DNA recombination in transgenic mice","volume":"89","author":"Orban","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032409274619300_r39","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nprot.2007.41","article-title":"Chemically induced mouse models of intestinal inflammation","volume":"2","author":"Wirtz","year":"2007","journal-title":"Nat. Protoc."},{"key":"2025032409274619300_r40","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/S0002-9440(10)64466-5","article-title":"Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2","volume":"161","author":"Cenac","year":"2002","journal-title":"Am. J. Pathol."},{"key":"2025032409274619300_r41","doi-asserted-by":"crossref","first-page":"15736","DOI":"10.1073\/pnas.0404722101","article-title":"A beta-oxidation-resistant lipoxin A4 analog treats hapten-induced colitis by attenuating inflammation and immune dysfunction","volume":"101","author":"Fiorucci","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032409274619300_r42","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0092-8674(00)80702-3","article-title":"A novel transcription factor, T-bet, directs Th1 lineage commitment","volume":"100","author":"Szabo","year":"2000","journal-title":"Cell"},{"key":"2025032409274619300_r43","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/nri954","article-title":"The lineage decisions of helper T cells","volume":"2","author":"Murphy","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"2025032409274619300_r44","first-page":"223","article-title":"Th1\/Th2 balance: the hypothesis, its limitations, and implications for health and disease","volume":"8","author":"Kidd","year":"2003","journal-title":"Altern. Med. Rev."},{"key":"2025032409274619300_r45","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1365-2249.2007.03356.x","article-title":"The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease","volume":"148","author":"Afzali","year":"2007","journal-title":"Clin. Exp. Immunol."},{"key":"2025032409274619300_r46","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0092-8674(00)80047-1","article-title":"SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine","volume":"98","author":"Alexander","year":"1999","journal-title":"Cell"},{"key":"2025032409274619300_r47","doi-asserted-by":"crossref","first-page":"10626","DOI":"10.1073\/pnas.95.18.10626","article-title":"Inhibition of Stat1-mediated gene activation by PIAS1","volume":"95","author":"Liu","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032409274619300_r48","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.molcel.2008.06.017","article-title":"Nuclear beta-arrestin1 functions as a scaffold for the dephosphorylation of STAT1 and moderates the antiviral activity of IFN-gamma","volume":"31","author":"Mo","year":"2008","journal-title":"Mol. Cell"},{"key":"2025032409274619300_r49","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/j.jaci.2005.08.032","article-title":"Astilbin inhibits contact hypersensitivity through negative cytokine regulation distinct from cyclosporin A","volume":"116","author":"Fei","year":"2005","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025032409274619300_r50","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1365-2249.1995.tb05574.x","article-title":"The effect of cyclosporin A, FK506, and rapamycin on the murine chronic graft-versus-host response\u2014an in vivo model of Th2-like activity","volume":"99","author":"Bundick","year":"1995","journal-title":"Clin. Exp. Immunol."},{"key":"2025032409274619300_r51","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1080\/03009740310004351","article-title":"Predominant inhibition of Th1 cytokines in New Zealand black\/white F1 mice treated with FK506","volume":"33","author":"Sugiyama","year":"2004","journal-title":"Scand. J. Rheumatol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/189\/7\/3497\/61725729\/1201006.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/189\/7\/3497\/61725729\/1201006.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T07:26:10Z","timestamp":1743060370000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/189\/7\/3497\/7994766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,1]]},"references-count":51,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,10,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1201006","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2012,10]]},"published":{"date-parts":[[2012,10,1]]}}}