{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:35:09Z","timestamp":1791232509663,"version":"4.1.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population of myeloid cells in cancer patients and tumor-bearing mice that potently inhibits T cell responses. During tumor progression, MDSCs accumulate in several organs, including the tumor tissue. So far, tumor-infiltrating MDSC subpopulations remain poorly explored. In this study, we performed global gene expression profiling of mouse tumor-infiltrating granulocytic and monocytic (MO-MDSC) subsets compared with MDSCs from peripheral blood. RMA-S lymphoma\u2013infiltrating MO-MDSCs not only produced high levels of NO and arginase-1, but also greatly increased levels of chemokines comprising the CCR5 ligands CCL3, CCL4, and CCL5. MO-MDSCs isolated from B16 melanoma and from skin tumor\u2013bearing ret transgenic mice also expressed high levels of CCL3, CCL4, and CCL5. Expression of CCR5 was preferentially detected on regulatory T cells (Tregs). Accordingly, tumor-infiltrating MO-MDSCs directly attracted high numbers of Tregs via CCR5 in vitro. Intratumoral injection of CCL4 or CCL5 increased tumor-infiltrating Tregs, and deficiency of CCR5 led to their profound decrease. Moreover, in CCR5-deficient mice, RMA-S and B16 tumor growth was delayed emphasizing the importance of CCR5 in the control of antitumor immune responses. Overall, our data demonstrate that chemokines secreted by tumor-infiltrating MO-MDSCs recruit high numbers of Tregs revealing a novel suppressive role of MDSCs with potential clinical implications for the development of cancer immunotherapies.<\/jats:p>","DOI":"10.4049\/jimmunol.1201018","type":"journal-article","created":{"date-parts":[[2012,11,14]],"date-time":"2012-11-14T22:16:08Z","timestamp":1352931368000},"page":"5602-5611","source":"Crossref","is-referenced-by-count":390,"title":["Tumor-Infiltrating Monocytic Myeloid-Derived Suppressor Cells Mediate CCR5-Dependent Recruitment of Regulatory T Cells Favoring Tumor Growth"],"prefix":"10.1093","volume":"189","author":[{"given":"Eva","family":"Schlecker","sequence":"first","affiliation":[{"name":"Innate Immunity, Research Program Tumor Immunology, German Cancer Research Center , Heidelberg D-69120,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Stojanovic","sequence":"additional","affiliation":[{"name":"Innate Immunity, Research Program Tumor Immunology, German Cancer Research Center , Heidelberg D-69120,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Eisen","sequence":"additional","affiliation":[{"name":"Division of Stem Cells and Cancer, German Cancer Research Center , Heidelberg D-69120,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Quack","sequence":"additional","affiliation":[{"name":"Immune Monitoring Unit, National Center for Tumor Diseases, German Cancer Research Center , Heidelberg D-69120,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine S","family":"Falk","sequence":"additional","affiliation":[{"name":"Immune Monitoring Unit, National Center for Tumor Diseases, German Cancer Research Center , Heidelberg D-69120,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor","family":"Umansky","sequence":"additional","affiliation":[{"name":"Skin Cancer Unit, German Cancer Research Center , Heidelberg D-69120,","place":["Germany"]},{"name":"Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg , Mannheim, Heidelberg 68167,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelheid","family":"Cerwenka","sequence":"additional","affiliation":[{"name":"Innate Immunity, Research Program Tumor Immunology, German Cancer Research Center , Heidelberg D-69120,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,12,15]]},"reference":[{"key":"2025032409400991100_r1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1146\/annurev.immunol.25.022106.141609","article-title":"Immunosuppressive strategies that are mediated by tumor cells","volume":"25","author":"Rabinovich","year":"2007","journal-title":"Annu. 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