{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:37:45Z","timestamp":1792165065410,"version":"4.4.0"},"reference-count":77,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The low-grade oral infection chronic periodontitis (CP) has been implicated in coronary artery disease risk, but the mechanisms are unclear. In this study, a pathophysiological role for blood dendritic cells (DCs) in systemic dissemination of oral mucosal pathogens to atherosclerotic plaques was investigated in humans. The frequency and microbiome of CD19\u2212BDCA-1+DC-SIGN+ blood myeloid DCs (mDCs) were analyzed in CP subjects with or without existing acute coronary syndrome and in healthy controls. FACS analysis revealed a significant increase in blood mDCs in the following order: healthy controls &amp;lt; CP &amp;lt; acute coronary syndrome\/CP. Analysis of the blood mDC microbiome by 16S rDNA sequencing showed Porphyromonas gingivalis and other species, including (cultivable) Burkholderia cepacia. The mDC carriage rate with P. gingivalis correlated with oral carriage rate and with serologic exposure to P. gingivalis in CP subjects. Intervention (local debridement) to elicit a bacteremia increased the mDC carriage rate and frequency in vivo. In vitro studies established that P. gingivalis enhanced by 28% the differentiation of monocytes into immature mDCs; moreover, mDCs secreted high levels of matrix metalloproteinase-9 and upregulated C1q, heat shock protein 60, heat shock protein 70, CCR2, and CXCL16 transcripts in response to P. gingivalis in a fimbriae-dependent manner. Moreover, the survival of the anaerobe P. gingivalis under aerobic conditions was enhanced when within mDCs. Immunofluorescence analysis of oral mucosa and atherosclerotic plaques demonstrate infiltration with mDCs, colocalized with P. gingivalis. Our results suggest a role for blood mDCs in harboring and disseminating pathogens from oral mucosa to atherosclerosis plaques, which may provide key signals for mDC differentiation and atherogenic conversion.<\/jats:p>","DOI":"10.4049\/jimmunol.1201053","type":"journal-article","created":{"date-parts":[[2012,8,14]],"date-time":"2012-08-14T02:36:34Z","timestamp":1344911794000},"page":"3178-3187","source":"Crossref","is-referenced-by-count":153,"title":["Microbial Carriage State of Peripheral Blood Dendritic Cells (DCs) in Chronic Periodontitis Influences DC Differentiation, Atherogenic Potential"],"prefix":"10.1093","volume":"189","author":[{"given":"Julio","family":"Carrion","sequence":"first","affiliation":[{"name":"School of Dental Medicine, Stony Brook University , Stony Brook, NY 11794"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Scisci","sequence":"additional","affiliation":[{"name":"School of Dental Medicine, Stony Brook University , Stony Brook, NY 11794"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brodie","family":"Miles","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, Center for Infectious Diseases, Stony Brook University , Stony Brook, NY 11794"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory J","family":"Sabino","sequence":"additional","affiliation":[{"name":"School of Dental Medicine, Stony Brook University , Stony Brook, NY 11794"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir E","family":"Zeituni","sequence":"additional","affiliation":[{"name":"School of Dental Medicine, Stony Brook University , Stony Brook, NY 11794"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Gu","sequence":"additional","affiliation":[{"name":"School of Dental Medicine, Stony Brook University , Stony Brook, NY 11794"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Bear","sequence":"additional","affiliation":[{"name":"School of Dental Medicine, Stony Brook University , Stony Brook, NY 11794"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline A","family":"Genco","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Medicine, Boston University School of Medicine , Boston, MA 02118"},{"name":"Department of Microbiology, Boston University School of Medicine , Boston, MA 02118"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Cardiology, School of Medicine, Stony Brook University , Stony Brook, NY 11794"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher W","family":"Cutler","sequence":"additional","affiliation":[{"name":"College of Dental Medicine, Georgia Health Sciences University , Augusta, GA 30912"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,9,15]]},"reference":[{"key":"2025032409240376600_r1","doi-asserted-by":"crossref","first-page":"2H","DOI":"10.1016\/j.amjcard.2006.03.002","article-title":"From vulnerable plaque to vulnerable patient\u2014Part III: Executive summary of the Screening for Heart Attack Prevention and Education (SHAPE) Task Force report","volume":"98","author":"Naghavi","year":"2006","journal-title":"Am. J. Cardiol."},{"key":"2025032409240376600_r2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1161\/01.CIR.0000023452.26135.34","article-title":"Shouldering the risk factor burden: infection, atherosclerosis, and the vascular endothelium","volume":"106","author":"Vita","year":"2002","journal-title":"Circulation"},{"key":"2025032409240376600_r3","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1177\/1753944709345598","article-title":"Infections as a stimulus for coronary occlusion, obstruction, or acute coronary syndromes","volume":"3","author":"Pesonen","year":"2009","journal-title":"Ther. Adv. Cardiovasc. Dis."},{"key":"2025032409240376600_r4","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1177\/154405910608500202","article-title":"Innate immune signaling and Porphyromonas gingivalis-accelerated atherosclerosis","volume":"85","author":"Gibson","year":"2006","journal-title":"J. Dent. Res."},{"key":"2025032409240376600_r5","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1902\/jop.2009.080007","article-title":"Results from the Periodontitis and Vascular Events (PAVE) Study: a pilot multicentered, randomized, controlled trial to study effects of periodontal therapy in a secondary prevention model of cardiovascular disease","volume":"80","author":"Offenbacher","year":"2009","journal-title":"J. Periodontol."},{"key":"2025032409240376600_r6","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1902\/jop.2005.76.11-S.2089","article-title":"Systemic effects of periodontitis: epidemiology of periodontal disease and cardiovascular disease","volume":"76","author":"Beck","year":"2005","journal-title":"J. Periodontol."},{"key":"2025032409240376600_r7","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/ki.2008.660","article-title":"Periodontal disease adversely affects the survival of patients with end-stage renal disease","volume":"75","author":"Kshirsagar","year":"2009","journal-title":"Kidney Int."},{"key":"2025032409240376600_r8","doi-asserted-by":"crossref","first-page":"5782","DOI":"10.3402\/jom.v2i0.5782","article-title":"Porphyromonas ginigvalis-dendritic cell interactions: consequences for coronary artery disease","volume":"2","author":"Zeituni","year":"2010","journal-title":"J. Oral Microbiol."},{"key":"2025032409240376600_r9","doi-asserted-by":"crossref","first-page":"5694","DOI":"10.4049\/jimmunol.0901030","article-title":"Targeting of DC-SIGN on human dendritic cells by minor fimbriated Porphyromonas gingivalis strains elicits a distinct effector T cell response","volume":"183","author":"Zeituni","year":"2009","journal-title":"J. Immunol."},{"key":"2025032409240376600_r10","doi-asserted-by":"crossref","first-page":"4103","DOI":"10.1128\/JB.00275-10","article-title":"The native 67-kilodalton minor fimbria of Porphyromonas gingivalis is a novel glycoprotein with DC-SIGN-targeting motifs","volume":"192","author":"Zeituni","year":"2010","journal-title":"J. Bacteriol."},{"key":"2025032409240376600_r11","doi-asserted-by":"crossref","first-page":"298","DOI":"10.7705\/biomedica.v29i2.31","article-title":"Distribution of Porphyromonas gingivalis fimA genotypes in isolates from subgingival plaque and blood sample during bacteremia","volume":"29","author":"P\u00e9rez-Chaparro","year":"2009","journal-title":"Biomedica"},{"key":"2025032409240376600_r12","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/j.1600-051X.2010.01599.x","article-title":"An investigation of the effect of an essential oil mouthrinse on induced bacteraemia: a pilot study","volume":"37","author":"Fine","year":"2010","journal-title":"J. Clin. Periodontol."},{"key":"2025032409240376600_r13","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1471-2180-8-26","article-title":"Intracellular survival and vascular cell-to-cell transmission of Porphyromonas gingivalis","volume":"8","author":"Li","year":"2008","journal-title":"BMC Microbiol."},{"key":"2025032409240376600_r14","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1538-7836.2009.03423.x","article-title":"The fate of monocytes in atherosclerosis","volume":"7","author":"Randolph","year":"2009","journal-title":"J. Thromb. Haemost."},{"key":"2025032409240376600_r15","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1161\/ATVBAHA.108.180505","article-title":"Regulation of the migration and survival of monocyte subsets by chemokine receptors and its relevance to atherosclerosis","volume":"29","author":"Gautier","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2025032409240376600_r16","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1093\/eurheartj\/ehi282","article-title":"Dendritic cells in atherosclerosis: current status of the problem and clinical relevance","volume":"26","author":"Bobryshev","year":"2005","journal-title":"Eur. Heart J."},{"key":"2025032409240376600_r17","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/nri2415","article-title":"The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models","volume":"8","author":"Weber","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"2025032409240376600_r18","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1679\/aohc.58.307","article-title":"Ultrastructural recognition of cells with dendritic cell morphology in human aortic intima. Contacting interactions of Vascular Dendritic Cells in athero-resistant and athero-prone areas of the normal aorta","volume":"58","author":"Bobryshev","year":"1995","journal-title":"Arch. Histol. Cytol."},{"key":"2025032409240376600_r19","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/MOL.0b013e32833ded96","article-title":"Resident intimal dendritic cells and the initiation of atherosclerosis","volume":"21","author":"Cybulsky","year":"2010","journal-title":"Curr. Opin. Lipidol."},{"key":"2025032409240376600_r20","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1161\/CIRCRESAHA.109.210781","article-title":"Resident intimal dendritic cells accumulate lipid and contribute to the initiation of atherosclerosis","volume":"106","author":"Paulson","year":"2010","journal-title":"Circ. Res."},{"key":"2025032409240376600_r21","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/labinvest.2010.94","article-title":"Dendritic cells and their role in atherogenesis","volume":"90","author":"Bobryshev","year":"2010","journal-title":"Lab. Invest."},{"key":"2025032409240376600_r22","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1369\/jhc.4B6570.2005","article-title":"Co-accumulation of dendritic cells and natural killer T cells within rupture-prone regions in human atherosclerotic plaques","volume":"53","author":"Bobryshev","year":"2005","journal-title":"J. Histochem. Cytochem."},{"key":"2025032409240376600_r23","doi-asserted-by":"crossref","first-page":"e74","DOI":"10.1182\/blood-2010-02-258558","article-title":"Nomenclature of monocytes and dendritic cells in blood","volume":"116","author":"Ziegler-Heitbrock","year":"2010","journal-title":"Blood"},{"key":"2025032409240376600_r24","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.1182\/blood-2008-12-180646","article-title":"Dendritic cell homeostasis","volume":"113","author":"Merad","year":"2009","journal-title":"Blood"},{"key":"2025032409240376600_r25","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.coi.2006.05.011","article-title":"Generation, migration and function of circulating dendritic cells","volume":"18","author":"Bonasio","year":"2006","journal-title":"Curr. Opin. Immunol."},{"key":"2025032409240376600_r26","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1177\/154405910308200915","article-title":"Multiple dendritic cell (DC) subpopulations in human gingiva and association of mature DCs with CD4+ T-cells in situ","volume":"82","author":"Jotwani","year":"2003","journal-title":"J. Dent. Res."},{"key":"2025032409240376600_r27","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.4049\/jimmunol.167.8.4693","article-title":"Mature dendritic cells infiltrate the T cell-rich region of oral mucosa in chronic periodontitis: in situ, in vivo, and in vitro studies","volume":"167","author":"Jotwani","year":"2001","journal-title":"J. Immunol."},{"key":"2025032409240376600_r28","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.atherosclerosis.2004.04.027","article-title":"Emergence of dendritic cells in rupture-prone regions of vulnerable carotid plaques","volume":"176","author":"Yilmaz","year":"2004","journal-title":"Atherosclerosis"},{"key":"2025032409240376600_r29","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1161\/01.ATV.0000121571.78696.dc","article-title":"Clinical and biochemical results of the metalloproteinase inhibition with subantimicrobial doses of doxycycline to prevent acute coronary syndromes (MIDAS) pilot trial","volume":"24","author":"Brown","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2025032409240376600_r30","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1084\/jem.20092140","article-title":"Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens","volume":"207","author":"Jongbloed","year":"2010","journal-title":"J. Exp. Med."},{"key":"2025032409240376600_r31","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1128\/IAI.72.3.1725-1732.2004","article-title":"Fimbriated Porphyromonas gingivalis is more efficient than fimbria-deficient P. gingivalis in entering human dendritic cells in vitro and induces an inflammatory Th1 effector response","volume":"72","author":"Jotwani","year":"2004","journal-title":"Infect. Immun."},{"key":"2025032409240376600_r32","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1056\/NEJMoa063186","article-title":"Treatment of periodontitis and endothelial function","volume":"356","author":"Tonetti","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"2025032409240376600_r33","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1111\/j.1600-051X.2007.01125.x","article-title":"Periodontopathic microorganisms in peripheric blood after scaling and root planing","volume":"34","author":"Lafaurie","year":"2007","journal-title":"J. Clin. Periodontol."},{"key":"2025032409240376600_r34","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1399-302X.2006.00296.x","article-title":"Immunoglobulin G subclass antibody profiles in Porphyromonas gingivalis-associated aggressive and chronic periodontitis patients","volume":"21","author":"Takeuchi","year":"2006","journal-title":"Oral Microbiol. Immunol."},{"key":"2025032409240376600_r35","doi-asserted-by":"crossref","first-page":"3504","DOI":"10.1128\/JCM.37.11.3504-3508.1999","article-title":"Improved multiplex PCR using conserved and species-specific 16S rRNA gene primers for simultaneous detection of Actinobacillus actinomycetemcomitans, Bacteroides forsythus, and Porphyromonas gingivalis","volume":"37","author":"Tran","year":"1999","journal-title":"J. Clin. Microbiol."},{"key":"2025032409240376600_r36","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1128\/CVI.00362-08","article-title":"Francisella tularensis infection-derived monoclonal antibodies provide detection, protection, and therapy","volume":"16","author":"Savitt","year":"2009","journal-title":"Clin. Vaccine Immunol."},{"key":"2025032409240376600_r37","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1128\/IAI.73.2.687-694.2005","article-title":"Oral mucosal endotoxin tolerance induction in chronic periodontitis","volume":"73","author":"Muthukuru","year":"2005","journal-title":"Infect. Immun."},{"key":"2025032409240376600_r38","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1034\/j.1399-302x.2000.150303.x","article-title":"Antigenic cross-reactivity among Porphyromonas gingivalis serotypes","volume":"15","author":"Fan","year":"2000","journal-title":"Oral Microbiol. Immunol."},{"key":"2025032409240376600_r39","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2217\/fca.11.75","article-title":"Bacterial invasion of vascular cell types: vascular infectology and atherogenesis","volume":"8","author":"Kozarov","year":"2012","journal-title":"Future Cardiol."},{"key":"2025032409240376600_r40","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1365-2249.2005.02897.x","article-title":"Reduced blood BDCA-2+ (lymphoid) and CD11c+ (myeloid) dendritic cells in systemic lupus erythematosus","volume":"142","author":"Migita","year":"2005","journal-title":"Clin. Exp. Immunol."},{"key":"2025032409240376600_r41","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1042\/CS20100440","article-title":"Decreased numbers of peripheral blood dendritic cells in patients with coronary artery disease are associated with diminished plasma Flt3 ligand levels and impaired plasmacytoid dendritic cell function","volume":"120","author":"Van Brussel","year":"2011","journal-title":"Clin. Sci."},{"key":"2025032409240376600_r42","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1161\/CIRCULATIONAHA.109.849455","article-title":"Insights into the role of infection in atherogenesis and in plaque rupture","volume":"119","author":"Epstein","year":"2009","journal-title":"Circulation"},{"key":"2025032409240376600_r43","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1365-3083.2011.02584.x","article-title":"Periodontopathogen- and host-derived immune response in acute coronary syndrome","volume":"74","author":"Alfakry","year":"2011","journal-title":"Scand. J. Immunol."},{"key":"2025032409240376600_r44","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1161\/01.ATV.0000155018.67835.1a","article-title":"Human atherosclerotic plaque contains viable invasive Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis","volume":"25","author":"Kozarov","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2025032409240376600_r45","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1189\/jlb.0810463","article-title":"DC-SIGN ligation greatly affects dendritic cell differentiation from monocytes compromising their normal function","volume":"89","author":"Svajger","year":"2011","journal-title":"J. Leukoc. Biol."},{"key":"2025032409240376600_r46","doi-asserted-by":"crossref","first-page":"979","DOI":"10.7326\/0003-4819-125-12-199612150-00008","article-title":"Isolation of Chlamydia pneumoniae from the coronary artery of a patient with coronary atherosclerosis. The Chlamydia pneumoniae\/Atherosclerosis Study Group","volume":"125","author":"Ramirez","year":"1996","journal-title":"Ann. Intern. Med."},{"key":"2025032409240376600_r47","doi-asserted-by":"crossref","first-page":"e35","DOI":"10.1161\/ATVBAHA.111.225623","article-title":"Matrix metalloproteinase (MMP)-3 activates MMP-9 mediated vascular smooth muscle cell migration and neointima formation in mice","volume":"31","author":"Johnson","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2025032409240376600_r48","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1078\/0171-2985-00193","article-title":"Active matrix metalloprotease-9 in and migration pattern of dendritic cells matured in clinical grade culture conditions","volume":"206","author":"Hollender","year":"2002","journal-title":"Immunobiology"},{"key":"2025032409240376600_r49","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1160\/TH09-02-0103","article-title":"Local complement activation triggers neutrophil recruitment to the site of thrombus formation in acute myocardial infarction","volume":"102","author":"Distelmaier","year":"2009","journal-title":"Thromb. Haemost."},{"key":"2025032409240376600_r50","doi-asserted-by":"crossref","first-page":"513","DOI":"10.2174\/138945009788488387","article-title":"Toll-like receptors: link between \u201cdanger\u201d ligands and plaque instability","volume":"10","author":"Balogh","year":"2009","journal-title":"Curr. Drug Targets"},{"key":"2025032409240376600_r51","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1042\/CS20080581","article-title":"Role of MCP-1 in cardiovascular disease: molecular mechanisms and clinical implications","volume":"117","author":"Niu","year":"2009","journal-title":"Clin. Sci."},{"key":"2025032409240376600_r52","doi-asserted-by":"crossref","first-page":"264","DOI":"10.3143\/geriatrics.39.264","article-title":"[New oxidized LDL receptors and their functions in atherogenesis]","volume":"39","author":"Kume","year":"2002","journal-title":"Nihon Ronen Igakkai Zasshi"},{"key":"2025032409240376600_r53","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s11239-010-0471-7","article-title":"Inflammatory response to percutaneous coronary intervention in stable coronary artery disease","volume":"31","author":"Munk","year":"2011","journal-title":"J. Thromb. Thrombolysis"},{"key":"2025032409240376600_r54","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1177\/154405910408300504","article-title":"Increase in HIV receptors\/co-receptors\/alpha-defensins in inflamed human gingiva","volume":"83","author":"Jotwani","year":"2004","journal-title":"J. Dent. Res."},{"key":"2025032409240376600_r55","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1067\/mva.2002.121067","article-title":"Expression of heat shock protein-70 by dendritic cells in the arterial intima and its potential significance in atherogenesis","volume":"35","author":"Bobryshev","year":"2002","journal-title":"J. Vasc. Surg."},{"key":"2025032409240376600_r56","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.1128\/IAI.66.7.3106-3112.1998","article-title":"Cloning of the heat shock protein 70 (HSP70) gene of Ehrlichia sennetsu and differential expression of HSP70 and HSP60 mRNA after temperature upshift","volume":"66","author":"Zhang","year":"1998","journal-title":"Infect. Immun."},{"key":"2025032409240376600_r57","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1034\/j.1600-051X.2002.290612.x","article-title":"Serum IgG to heat shock proteins and Porphyromonas gingivalis antigens in diabetic patients with periodontitis","volume":"29","author":"Sims","year":"2002","journal-title":"J. Clin. Periodontol."},{"key":"2025032409240376600_r58","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/path.1205","article-title":"Human atherosclerotic plaques express DC-SIGN, a novel protein found on dendritic cells and macrophages","volume":"198","author":"Soilleux","year":"2002","journal-title":"J. Pathol."},{"key":"2025032409240376600_r59","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/ni.1778","article-title":"Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori","volume":"10","author":"Gringhuis","year":"2009","journal-title":"Nat. Immunol."},{"key":"2025032409240376600_r60","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1574-695X.2009.00637.x","article-title":"MMP-9\/TIMP-1 imbalance induced in human dendritic cells by Porphyromonas gingivalis","volume":"58","author":"Jotwani","year":"2010","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"2025032409240376600_r61","doi-asserted-by":"crossref","first-page":"385","DOI":"10.33549\/physiolres.931764","article-title":"Levels of circulating biomarkers at rest and after exercise in coronary artery disease patients","volume":"59","author":"Danzig","year":"2010","journal-title":"Physiol. Res."},{"key":"2025032409240376600_r62","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1902\/jop.2010.100100","article-title":"Expression of hypoxia-inducible factor-1\u03b1 in human periodontal tissue","volume":"82","author":"Ng","year":"2011","journal-title":"J. Periodontol."},{"key":"2025032409240376600_r63","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1161\/01.ATV.0000036418.04998.D5","article-title":"Endothelial determinants of dendritic cell adhesion and migration: new implications for vascular diseases","volume":"22","author":"Weis","year":"2002","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2025032409240376600_r64","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1177\/154405910608500801","article-title":"Dendritic cells at the oral mucosal interface","volume":"85","author":"Cutler","year":"2006","journal-title":"J. Dent. Res."},{"key":"2025032409240376600_r65","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.transci.2008.06.008","article-title":"Update on bacteraemia related to dental procedures","volume":"39","author":"Olsen","year":"2008","journal-title":"Transfus. Apheresis Sci."},{"key":"2025032409240376600_r66","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1006\/clim.2002.5287","article-title":"Dendritic cells are decreased in blood and accumulated in granuloma in tuberculosis","volume":"105","author":"Uehira","year":"2002","journal-title":"Clin. Immunol."},{"key":"2025032409240376600_r67","doi-asserted-by":"crossref","first-page":"6700","DOI":"10.1128\/IAI.00861-06","article-title":"The frequency of BDCA3-positive dendritic cells is increased in the peripheral circulation of Kenyan children with severe malaria","volume":"74","author":"Urban","year":"2006","journal-title":"Infect. Immun."},{"key":"2025032409240376600_r68","doi-asserted-by":"crossref","first-page":"6364","DOI":"10.4049\/jimmunol.1001605","article-title":"Expanded numbers of circulating myeloid dendritic cells in patent human filarial infection reflect lower CCR1 expression","volume":"185","author":"Semnani","year":"2010","journal-title":"J. Immunol."},{"key":"2025032409240376600_r69","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jaci.2010.04.006","article-title":"Myeloid and plasmacytoid dendritic cells in induced sputum after allergen inhalation in subjects with asthma","volume":"126","author":"Dua","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025032409240376600_r70","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.amjcard.2007.03.067","article-title":"Peripheral-blood dendritic cells in men with coronary heart disease","volume":"100","author":"Shi","year":"2007","journal-title":"Am. J. Cardiol."},{"key":"2025032409240376600_r71","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1042\/CS20080392","article-title":"Predictive value of the decrease in circulating dendritic cell precursors in stable coronary artery disease","volume":"116","author":"Yilmaz","year":"2009","journal-title":"Clin. Sci."},{"key":"2025032409240376600_r72","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1253\/circj.CJ-08-1193","article-title":"High ratio of myeloid dendritic cells to plasmacytoid dendritic cells in blood of patients with acute coronary syndrome","volume":"73","author":"Fukunaga","year":"2009","journal-title":"Circ. J."},{"key":"2025032409240376600_r73","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/MCA.0b013e3283368c0e","article-title":"Changes in blood dendritic cell counts in relation to type of coronary artery disease and brachial endothelial cell function","volume":"21","author":"Van Vr\u00e9","year":"2010","journal-title":"Coron. Artery Dis."},{"key":"2025032409240376600_r74","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.4049\/jimmunol.174.5.3067","article-title":"Increased blood myeloid dendritic cells and dendritic cell-poietins in Langerhans cell histiocytosis","volume":"174","author":"Rolland","year":"2005","journal-title":"J. Immunol."},{"key":"2025032409240376600_r75","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1574-6968.2007.00736.x","article-title":"Porphyromonas gingivalis infection and cell death in human aortic endothelial cells","volume":"272","author":"Roth","year":"2007","journal-title":"FEMS Microbiol. Lett."},{"key":"2025032409240376600_r76","doi-asserted-by":"crossref","first-page":"e805","DOI":"10.1111\/j.1365-2567.2009.03086.x","article-title":"Bacterial signalling overrides cytokine signalling and modifies dendritic cell differentiation","volume":"128","author":"Davies","year":"2009","journal-title":"Immunology"},{"key":"2025032409240376600_r77","first-page":"365","article-title":"Primer3 on the WWW for general users and for biologist programmers","volume":"132","author":"Rozen","year":"2000","journal-title":"Methods Mol. Biol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/189\/6\/3178\/61714550\/1201053.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/189\/6\/3178\/61714550\/1201053.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T06:37:31Z","timestamp":1743057451000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/189\/6\/3178\/7993646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":77,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,9,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1201053","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2012,9]]},"published":{"date-parts":[[2012,9]]}}}