{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:19:35Z","timestamp":1778656775377,"version":"3.51.4"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Asthma is a chronic condition with high morbidity and healthcare costs, and cockroach allergens are an established cause of urban pediatric asthma. A better understanding of cell types involved in promoting lung inflammation could provide new targets for the treatment of chronic pulmonary disease. Because of its role in regulating myeloid cell-dependent inflammatory processes, we examined A2B R expression by myeloid cells in a cockroach allergen model of murine asthma-like pulmonary inflammation. Both systemic and myeloid tissue-specific A2B R deletion significantly decreased pulmonary inflammatory cell recruitment, airway mucin production, and proinflammatory cytokine secretion after final allergen challenge in sensitized mice. A2B R deficiency resulted in a dramatic reduction on Th2-type airways responses with decreased pulmonary eosinophilia without augmenting neutrophilia, and decreased lung IL-4, IL-5, and IL-13 production. Chemokine analysis demonstrated that eotaxin 1 and 2 secretion in response to repeated allergen challenge is myeloid cell A2B R dependent. In contrast, there were no differences in the levels of the CXC chemokines keratinocyte-derived chemokine and MIP-2 in the myeloid cell A2B R-deficient mice, strengthening A2B R involvement in the development of Th2-type airways inflammation. Proinflammatory TNF-\u03b1, IFN-\u03b3, and IL-17 secretion were also reduced in systemic and myeloid tissue-specific A2B R deletion mouse lines. Our results demonstrate Th2-type predominance for A2B R expression by myeloid cells as a mechanism of development of asthma-like pulmonary inflammation.<\/jats:p>","DOI":"10.4049\/jimmunol.1201207","type":"journal-article","created":{"date-parts":[[2012,9,7]],"date-time":"2012-09-07T00:26:14Z","timestamp":1346977574000},"page":"3707-3713","source":"Crossref","is-referenced-by-count":24,"title":["A2B Adenosine Receptor Expression by Myeloid Cells Is Proinflammatory in Murine Allergic-Airway Inflammation"],"prefix":"10.1093","volume":"189","author":[{"given":"Bryan G","family":"Belikoff","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Boston University School of Medicine , Boston, MA 02118"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis J","family":"Vaickus","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Boston University School of Medicine , Boston, MA 02118"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michail","family":"Sitkovsky","sequence":"additional","affiliation":[{"name":"New England Inflammation and Tissue Protection Institute, Northeastern University , Boston, MA 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel G","family":"Remick","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Boston University School of Medicine , Boston, MA 02118"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,10,1]]},"reference":[{"key":"2025032409261035200_r1","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/414916a","article-title":"Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage","volume":"414","author":"Ohta","year":"2001","journal-title":"Nature"},{"key":"2025032409261035200_r2","doi-asserted-by":"crossref","first-page":"7726","DOI":"10.4049\/jimmunol.172.12.7726","article-title":"Adenosine-activated mast cells induce IgE synthesis by B lymphocytes: an A2B-mediated process involving Th2 cytokines IL-4 and IL-13 with implications for asthma","volume":"172","author":"Ryzhov","year":"2004","journal-title":"J. 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