{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:16:18Z","timestamp":1790720178866,"version":"4.1.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Rag-1\u2013knockout (KO) mice are highly resistant to Listeria monocytogenes infection. The role played by the many Rag-1\u2013dependent lymphocyte lineages was studied using a genetic approach in which each Rag-1\u2013dependent lymphocyte lineage was eliminated one at a time. Only B cell-deficient Igh-KO mice displayed reduced bacterial load and improved survival upon Listeria infection. Listeria infection of Rag-1\u2013KO and Il-10\u2013KO hosts that had been adoptively transferred with wild-type marginal zone B (MZB) cells, but not follicular B cells, resulted in heightened bacterial load and increased Il-10 production in the spleen, but not the liver. This MZB cell-dependent increase in bacterial load was eliminated by anti\u2013Il-10 mAb. In addition, Listeria infection of MZB cell-deficient Rbpj-cKO mice showed decreased bacterial load and increased survival. Whereas multiple cell types have been shown to be capable of Il-10 production, our results indicate that the MZB cell is the most dominant and relevant Il-10 source in the context of Listeria susceptibility. In marked contrast to the generally protective nature of MZB cells in defending against pathogenic infection, our results demonstrate that MZB cells play a detrimental role in Listeria infection and possibly other infections as well.<\/jats:p>","DOI":"10.4049\/jimmunol.1201247","type":"journal-article","created":{"date-parts":[[2012,8,30]],"date-time":"2012-08-30T04:35:20Z","timestamp":1346301320000},"page":"3319-3327","source":"Crossref","is-referenced-by-count":40,"title":["Marginal Zone B Cell Is a Major Source of Il-10 in <i>Listeria monocytogenes<\/i> Susceptibility"],"prefix":"10.1093","volume":"189","author":[{"given":"Chen-Cheng","family":"Lee","sequence":"first","affiliation":[{"name":"Graduate Institute of Immunology, College of Medicine, National Taiwan University , Taipei 10051, Taiwan,","place":["Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T","family":"Kung","sequence":"additional","affiliation":[{"name":"Graduate Institute of Immunology, College of Medicine, National Taiwan University , Taipei 10051, Taiwan,","place":["Republic of China"]},{"name":"Institute of Molecular Biology, Academia Sinica , Taipei 11529, Taiwan,","place":["Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,10,1]]},"reference":[{"key":"2025032409272971200_r1","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1084\/jem.20060045","article-title":"Lymphocytes are detrimental during the early innate immune response against Listeria monocytogenes","volume":"203","author":"Carrero","year":"2006","journal-title":"J. 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