{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:06:56Z","timestamp":1761919616923,"version":"3.40.3"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Dendritic cells (DC) in the gut promote immune tolerance by expressing retinal dehydrogenase (RALDH), an enzyme that promotes retinoic acid, which aids differentiation of Foxp3+ inducible regulatory T cells (iTreg) in the intestinal mucosa. How RALDH expression is regulated is unclear. We found that 4-1BB (CD137), a member of the TNFR family, together with CD103, marked mesenteric lymph node DC with the highest level of RALDH activity, and ligation of 4-1BB maintained RALDH expression in these gut DC. Moreover, 4-1BB signals synergized with those through TLR2 or GM-CSFR to promote RALDH activity in undifferentiated DC. Correspondingly, 4-1BB\u2013deficient mice were impaired in their ability to generate iTreg in the GALT when exposed to oral Ag, and 4-1BB\u2013deficient mesenteric lymph node DC displayed weak RALDH activity and were poor at promoting iTreg development. Thus, our data demonstrate a novel activity of 4-1BB in controlling RALDH expression and the regulatory activity of DC.<\/jats:p>","DOI":"10.4049\/jimmunol.1201248","type":"journal-article","created":{"date-parts":[[2012,8,16]],"date-time":"2012-08-16T02:05:57Z","timestamp":1345082757000},"page":"2697-2701","source":"Crossref","is-referenced-by-count":31,"title":["Cutting Edge: 4-1BB Controls Regulatory Activity in Dendritic Cells through Promoting Optimal Expression of Retinal Dehydrogenase"],"prefix":"10.1093","volume":"189","author":[{"given":"Seung-Woo","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Immune Regulation, La Jolla Institute for Allergy and Immunology , La Jolla, CA 92037"},{"name":"Division of Integrative Bioscience and Biotechnology, Pohang University of Science and Technology , Pohang, Gyeongbuk 790-784,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunji","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Integrative Bioscience and Biotechnology, Pohang University of Science and Technology , Pohang, Gyeongbuk 790-784,","place":["Korea"]},{"name":"Developmental Immunology, La Jolla Institute for Allergy and Immunology , La Jolla, CA 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So-Young","family":"Eun","sequence":"additional","affiliation":[{"name":"Division of Immune Regulation, La Jolla Institute for Allergy and Immunology , La Jolla, CA 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shravan","family":"Madireddi","sequence":"additional","affiliation":[{"name":"Division of Immune Regulation, La Jolla Institute for Allergy and Immunology , La Jolla, CA 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilde","family":"Cheroutre","sequence":"additional","affiliation":[{"name":"Developmental Immunology, La Jolla Institute for Allergy and Immunology , La Jolla, CA 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Croft","sequence":"additional","affiliation":[{"name":"Division of Immune Regulation, La Jolla Institute for Allergy and Immunology , La Jolla, CA 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,9,15]]},"reference":[{"key":"2025032409231724900_r1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nri2710","article-title":"Immune adaptations that maintain homeostasis with the intestinal microbiota","volume":"10","author":"Hooper","year":"2010","journal-title":"Nat. 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