{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:44:30Z","timestamp":1791377070948,"version":"4.3.2"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Helminthic infections protect mice from colitis in murine models of inflammatory bowel disease and also may protect people. Helminths like Heligmosomoides polygyrus bakeri can induce regulatory T cells (Treg). Experiments explored whether H. polygyrus bakeri infection could protect mice from colitis through activation of colonic Treg and examined mechanisms of action. We showed that H. polygyrus bakeri infection increased the number of T cells expressing Foxp3 in the colon. More importantly, Foxp3+\/IL-10\u2212 and Foxp3+\/IL-10+ T cell subsets isolated from the colon of H. polygyrus bakeri\u2013infected mice prevented colitis when adoptively transferred into a murine model of inflammatory bowel disease, whereas Treg from uninfected mice could not provide protection. Only the transferred colonic Foxp3+\/IL-10\u2212 T cells from H. polygyrus bakeri\u2013infected mice readily accumulated in the colon and mesenteric lymph nodes of recipient mice, and they reconstituted the Foxp3+\/IL-10\u2212 and Foxp3+\/IL-10+ T cell subsets. However, transferred Foxp3+\/IL-10+ T cells disappeared. IL-10 expression by Foxp3+ T cells was necessary for colitis prevention. Thus, H. polygyrus bakeri infection activates colonic Foxp3+ T cells, making them highly regulatory. The Foxp3+ T cells that fail to express IL-10 may be critical for populating the colon with the Foxp3+\/IL-10+ T cells, which are required to control colitis.<\/jats:p>","DOI":"10.4049\/jimmunol.1201457","type":"journal-article","created":{"date-parts":[[2013,7,13]],"date-time":"2013-07-13T05:40:13Z","timestamp":1373694013000},"page":"1927-1934","source":"Crossref","is-referenced-by-count":68,"title":["<i>Heligmosomoides polygyrus bakeri<\/i> Infection Activates Colonic Foxp3+ T Cells Enhancing Their Capacity To Prevent Colitis"],"prefix":"10.1093","volume":"191","author":[{"given":"Long","family":"Hang","sequence":"first","affiliation":[{"name":"Division of Gastroenterology-Hepatology, Department of Internal Medicine, Tufts Medical Center , Boston, MA 02111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur M","family":"Blum","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology-Hepatology, Department of Internal Medicine, Tufts Medical Center , Boston, MA 02111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommy","family":"Setiawan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology-Hepatology, Department of Internal Medicine, Tufts Medical Center , Boston, MA 02111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Joseph P","family":"Urban","sequence":"additional","affiliation":[{"name":"Diet, Genomics, and Immunology Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, United States Department of Agriculture , Beltsville, MD 20705"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Korynn M","family":"Stoyanoff","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology-Hepatology, Department of Internal Medicine, Tufts Medical Center , Boston, MA 02111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel V","family":"Weinstock","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology-Hepatology, Department of Internal Medicine, Tufts Medical Center , Boston, MA 02111"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,8,15]]},"reference":[{"key":"2025032405174240700_r1","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1096\/fj.99-0885hyp","article-title":"Does the failure to acquire helminthic parasites predispose to Crohn\u2019s disease?","volume":"14","author":"Elliott","year":"2000","journal-title":"FASEB J."},{"key":"2025032405174240700_r2","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/ibd.20633","article-title":"Helminths and the IBD hygiene hypothesis","volume":"15","author":"Weinstock","year":"2009","journal-title":"Inflamm. 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