{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T08:59:36Z","timestamp":1790499576544,"version":"4.1.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Modulation of immune responses is one of the main research aims in transplant immunology. In this study, we investigate the local immunomodulatory properties of soluble CD83 (sCD83) at the graft-host interface using the high-risk corneal transplantation model. In this model, which mimics the inflammatory status and the preexisting vascularization of high-risk patients undergoing corneal transplantation, allogeneic donor corneas are transplanted onto sCD83-treated recipient animals. This model allows the direct and precise application of the immune modulator at the transplantation side. Interestingly, sCD83 was able to prolong graft survival after systemic application as well as after topical application, which is therapeutically more relevant. The therapeutic effect was accompanied by an increase in the frequency of regulatory T cells and was mediated by the immune-regulatory enzyme IDO and TGF-\u03b2. In vitro, sCD83 induced long-term IDO expression in both conventional and plasmacytoid dendritic cells via autocrine or paracrine production of TGF-\u03b2, a cytokine previously shown to be an essential mediator of IDO-dependent, long-term tolerance. These findings open new treatment avenues for local immune modulation after organ and tissue transplantation.<\/jats:p>","DOI":"10.4049\/jimmunol.1201531","type":"journal-article","created":{"date-parts":[[2013,7,13]],"date-time":"2013-07-13T05:40:13Z","timestamp":1373694013000},"page":"1965-1975","source":"Crossref","is-referenced-by-count":60,"title":["Topical Application of Soluble CD83 Induces IDO-Mediated Immune Modulation, Increases Foxp3+ T Cells, and Prolongs Allogeneic Corneal Graft Survival"],"prefix":"10.1093","volume":"191","author":[{"given":"Felix","family":"Bock","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Cologne , 50931 Cologne,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"R\u00f6ssner","sequence":"additional","affiliation":[{"name":"Department of Immune Modulation at the Department of Dermatology, University of Erlangen-Nuremberg , D-91052 Erlangen,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine","family":"Onderka","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Erlangen-N\u00fcrnberg , D-91052 Erlangen,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Lechmann","sequence":"additional","affiliation":[{"name":"Department of Immune Modulation at the Department of Dermatology, University of Erlangen-Nuremberg , D-91052 Erlangen,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Pallotta","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine and Biochemical Sciences, University of Perugia , 06100 Perugia,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Fallarino","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine and Biochemical Sciences, University of Perugia , 06100 Perugia,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Boon","sequence":"additional","affiliation":[{"name":"Bioceros , 3584 CM Utrecht,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Nicolette","sequence":"additional","affiliation":[{"name":"Argos Therapeutics, 4233 Technology Drive , Durham, NC 27704"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A","family":"DeBenedette","sequence":"additional","affiliation":[{"name":"Argos Therapeutics, 4233 Technology Drive , Durham, NC 27704"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina Y","family":"Tcherepanova","sequence":"additional","affiliation":[{"name":"Argos Therapeutics, 4233 Technology Drive , Durham, NC 27704"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Grohmann","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine and Biochemical Sciences, University of Perugia , 06100 Perugia,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Steinkasserer","sequence":"additional","affiliation":[{"name":"Department of Immune Modulation at the Department of Dermatology, University of Erlangen-Nuremberg , D-91052 Erlangen,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Cursiefen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Cologne , 50931 Cologne,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Zinser","sequence":"additional","affiliation":[{"name":"Department of Immune Modulation at the Department of Dermatology, University of Erlangen-Nuremberg , D-91052 Erlangen,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,8,15]]},"reference":[{"key":"2025032405182974100_r1","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/nm1251","article-title":"Organ transplantation\u2014how much of the promise has been realized?","volume":"11","author":"Lechler","year":"2005","journal-title":"Nat. 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