{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:41:10Z","timestamp":1759333270855,"version":"3.40.3"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The complement system has been shown to facilitate peripheral prion pathogenesis. Mice lacking complement receptors CD21\/35 partially resist terminal prion disease when infected i.p. with mouse-adapted scrapie prions. Chronic wasting disease (CWD) is an emerging prion disease of captive and free-ranging cervid populations that, similar to scrapie, has been shown to involve the immune system, which probably contributes to their relatively facile horizontal and environmental transmission. In this study, we show that mice overexpressing the cervid prion protein and susceptible to CWD (Tg(cerPrP)5037 mice) but lack CD21\/35 expression completely resist clinical CWD upon peripheral infection. CD21\/35-deficient Tg5037 mice exhibit greatly impaired splenic prion accumulation and replication throughout disease, similar to CD21\/35-deficient murine prion protein mice infected with mouse scrapie. TgA5037;CD21\/35\u2212\/\u2212 mice exhibited little or no neuropathology and deposition of misfolded, protease-resistant prion protein associated with CWD. CD21\/35 translocate to lipid rafts and mediates a strong germinal center response to prion infection that we propose provides the optimal environment for prion accumulation and replication. We further propose a potential role for CD21\/35 in selecting prion quasi-species present in prion strains that may exhibit differential zoonotic potential compared with the parental strains.<\/jats:p>","DOI":"10.4049\/jimmunol.1201579","type":"journal-article","created":{"date-parts":[[2012,9,23]],"date-time":"2012-09-23T00:14:55Z","timestamp":1348359295000},"page":"4520-4527","source":"Crossref","is-referenced-by-count":30,"title":["Genetic Depletion of Complement Receptors CD21\/35 Prevents Terminal Prion Disease in a Mouse Model of Chronic Wasting Disease"],"prefix":"10.1093","volume":"189","author":[{"given":"Brady","family":"Michel","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University Prion Research Center , Fort Collins, CO 80523"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University Prion Research Center , Fort Collins, CO 80523"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University Prion Research Center , Fort Collins, CO 80523"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Bender","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University Prion Research Center , Fort Collins, CO 80523"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Crystal","family":"Meyerett-Reid","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University Prion Research Center , Fort Collins, CO 80523"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Pulford","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University Prion Research Center , Fort Collins, CO 80523"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"von Teichman","sequence":"additional","affiliation":[{"name":"Institute for Neuropathology, University Hospital of Z\u00fcrich , CH-8091 Z\u00fcrich,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davis","family":"Seelig","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University Prion Research Center , Fort Collins, CO 80523"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H","family":"Weis","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Utah , Salt Lake City, UT 84132"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn C","family":"Telling","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University Prion Research Center , Fort Collins, CO 80523"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano","family":"Aguzzi","sequence":"additional","affiliation":[{"name":"Institute for Neuropathology, University Hospital of Z\u00fcrich , CH-8091 Z\u00fcrich,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark D","family":"Zabel","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University Prion Research Center , Fort Collins, CO 80523"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,11,1]]},"reference":[{"key":"2025032409331348400_r1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.7589\/0090-3558-18.4.465","article-title":"Spongiform encephalopathy of Rocky Mountain elk","volume":"18","author":"Williams","year":"1982","journal-title":"J. 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