{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:28:29Z","timestamp":1791178109256,"version":"4.1.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Sensitization and challenge using dinitrofluorobenzene (DNFB) induce contact hypersensitivity (CHS) with Th1 cell infiltration, whereas those using FITC generate CHS with Th2 cell infiltration. In this study, we attempted to determine the role of CXCR3, a chemokine receptor, in Th1- and Th2-type CHS induced by DNFB or FITC using CXCR3-deficient (CXCR3\u2212\/\u2212) mice. Ear swelling was prolonged after DNFB challenge in CXCR3\u2212\/\u2212 mice, which was accompanied by increased Th1 cytokines and decreased TGF-\u03b2 and IL-10 expression at a late time point of CHS, whereas there was no significant difference between wild-type and CXCR3\u2212\/\u2212 mice in FITC-induced CHS. In Th1-type CHS, the number of regulatory T cells (Tregs) was decreased in the challenged ear of CXCR3\u2212\/\u2212 mice compared with that of wild-type mice, suggesting that CXCR3 would be important in migration of Tregs into the site of inflammation. Moreover, we examined the characteristics of CXCR3+ Tregs both in vitro and in vivo, revealing that CXCR3+ Tregs expressed high levels of TGF-\u03b2 and IL-10 as well as IFN-\u03b3 compared with CXCR3\u2212 Tregs. When CXCR3\u2212\/\u2212 mice were injected with CXCR3+ Tregs, the prolonged ear swelling induced by DNFB was normalized. Taken together, our results suggest that CXCR3+ Tregs play a key role for quenching Th1-type CHS.<\/jats:p>","DOI":"10.4049\/jimmunol.1201606","type":"journal-article","created":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T03:59:36Z","timestamp":1368071976000},"page":"6059-6070","source":"Crossref","is-referenced-by-count":31,"title":["CXCR3 Deficiency Prolongs Th1-Type Contact Hypersensitivity"],"prefix":"10.1093","volume":"190","author":[{"given":"Hiraku","family":"Suga","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, University of Tokyo , Tokyo 113-8655,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Sugaya","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, University of Tokyo , Tokyo 113-8655,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomitsu","family":"Miyagaki","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, University of Tokyo , Tokyo 113-8655,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanako","family":"Ohmatsu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, University of Tokyo , Tokyo 113-8655,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Okochi","sequence":"additional","affiliation":[{"name":"Department of Regenerative Medicine, Research Institute, National Center for Global Health and Medicine , Tokyo 162-8655,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, University of Tokyo , Tokyo 113-8655,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,6,15]]},"reference":[{"key":"2025032407075347200_r1","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1002\/eji.200838397","article-title":"Insights into Langerhans cell function from Langerhans cell ablation models","volume":"38","author":"Kaplan","year":"2008","journal-title":"Eur. 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