{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:32:23Z","timestamp":1792715543906,"version":"4.5.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Nonlymphoid T cell populations control local infections and contribute to inflammatory diseases, thus driving efforts to understand the regulation of their migration, differentiation, and maintenance. Numerous observations indicate that T cell trafficking and differentiation within the lung are starkly different from what has been described in most nonlymphoid tissues, including intestine and skin. After systemic infection, we found that &amp;gt;95% of memory CD8 T cells isolated from mouse lung via standard methods were actually confined to the pulmonary vasculature, despite perfusion. A respiratory route of challenge increased virus-specific T cell localization within lung tissue, although only transiently. Removing blood-borne cells from analysis by the simple technique of intravascular staining revealed distinct phenotypic signatures and chemokine-dependent trafficking restricted to Ag-experienced T cells. These results precipitate a revised model for pulmonary T cell trafficking and differentiation and a re-evaluation of studies examining the contributions of pulmonary T cells to protection and disease.<\/jats:p>","DOI":"10.4049\/jimmunol.1201682","type":"journal-article","created":{"date-parts":[[2012,8,15]],"date-time":"2012-08-15T22:05:57Z","timestamp":1345068357000},"page":"2702-2706","source":"Crossref","is-referenced-by-count":298,"title":["Cutting Edge: Intravascular Staining Redefines Lung CD8 T Cell Responses"],"prefix":"10.1093","volume":"189","author":[{"given":"Kristin G","family":"Anderson","sequence":"first","affiliation":[{"name":"Department of Microbiology, Center for Immunology, University of Minnesota , Minneapolis, MN 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heungsup","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Center for Immunology, University of Minnesota , Minneapolis, MN 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cara N","family":"Skon","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Center for Immunology, University of Minnesota , Minneapolis, MN 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Lefrancois","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Connecticut Health Center , Farmington, CT 06030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Deisinger","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Center for Immunology, University of Minnesota , Minneapolis, MN 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaiva","family":"Vezys","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Center for Immunology, University of Minnesota , Minneapolis, MN 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Masopust","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Center for Immunology, University of Minnesota , Minneapolis, MN 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,9,15]]},"reference":[{"key":"2025032409234450900_r1","volume-title":"The World Health Report 2004\u2014Changing History.","author":"WHO","year":"2004"},{"key":"2025032409234450900_r2","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nm.2731","article-title":"Innate and adaptive immune responses in asthma","volume":"18","author":"Holgate","year":"2012","journal-title":"Nat. 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