{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:07:38Z","timestamp":1792735658123,"version":"4.5.0"},"reference-count":81,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>CMV and varicella zoster virus (VZV) are significant causes of morbidity and mortality following umbilical cord blood transplantation (UCBT). However, the kinetics of reconstitution and protective potential of antiviral cell-mediated immune responses following UCBT remain poorly characterized. In this study, the reconstitution of CMV- and VZV-specific T cell responses was assessed using IFN-\u03b3 ELISPOT in 28 children who underwent UCBT to treat hematological or inherited disorders. Barely detectable in the first 3 mo posttransplantation, CMV- and VZV-specific T cell responses were observed in 30.4% and 40.3% of study subjects after 36 mo of follow-up. Four of five CMV-seropositive subjects developed detectable levels of circulating CMV DNA (DNAemia), and 5 of 17 VZV-seropositive patients experienced herpes zoster during the posttransplant period. Four CMV-seronegative subjects developed IFN-\u03b3 responses against CMV, and four subjects developed a VZV-specific IFN-\u03b3 response without clinical signs of infection. No CMV- or VZV-related events were observed in study subjects following the development of CMV- or VZV-specific responses &amp;gt; 150 spot-forming units\/106 PBMCs, consistent with T cell-mediated protection. Finally, famciclovir prophylaxis did not strictly prevent the reconstitution of the VZV-specific T cell repertoire, because the frequency of T cells producing IFN-\u03b3 in response to VZV Ags reached levels consistent with protection in two nonzoster subjects. Monitoring of CMV- and VZV-specific cell-mediated immunity could inform immunocompetence and guide the initiation and cessation of antiherpetic prophylaxis in UCBT recipients.<\/jats:p>","DOI":"10.4049\/jimmunol.1201759","type":"journal-article","created":{"date-parts":[[2012,10,4]],"date-time":"2012-10-04T03:05:03Z","timestamp":1349319903000},"page":"5016-5028","source":"Crossref","is-referenced-by-count":13,"title":["Reconstitution of Protective Immune Responses against Cytomegalovirus and Varicella Zoster Virus Does Not Require Disease Development in Pediatric Recipients of Umbilical Cord Blood Transplantation"],"prefix":"10.1093","volume":"189","author":[{"given":"Natacha","family":"Merindol","sequence":"first","affiliation":[{"name":"Unit\u00e9 d\u2019Immunopathologie Virale, Centre de Recherche du Centre Hospitalier Universitaire Sainte-Justine , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Groupe de Recherche en Transplantation et Immunologie du Sang de Cordon, Centre de Canc\u00e9rologie Charles-Bruneau , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"D\u00e9partement de Microbiologie et Immunologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montr\u00e9al , Montreal, Quebec H3T 1J4,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Insaf","family":"Salem Fourati","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d\u2019Immunopathologie Virale, Centre de Recherche du Centre Hospitalier Universitaire Sainte-Justine , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Groupe de Recherche en Transplantation et Immunologie du Sang de Cordon, Centre de Canc\u00e9rologie Charles-Bruneau , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"D\u00e9partement de Microbiologie et Immunologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montr\u00e9al , Montreal, Quebec H3T 1J4,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose-Marie","family":"Brito","sequence":"additional","affiliation":[{"name":"Groupe de Recherche en Transplantation et Immunologie du Sang de Cordon, Centre de Canc\u00e9rologie Charles-Bruneau , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"D\u00e9partement de Microbiologie et Immunologie, Centre Hospitalier Universitaire Sainte-Justine , Montreal, Quebec H3T 1C5,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Julie","family":"Grenier","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d\u2019Immunopathologie Virale, Centre de Recherche du Centre Hospitalier Universitaire Sainte-Justine , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Groupe de Recherche en Transplantation et Immunologie du Sang de Cordon, Centre de Canc\u00e9rologie Charles-Bruneau , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"D\u00e9partement de Microbiologie et Immunologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montr\u00e9al , Montreal, Quebec H3T 1J4,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Charrier","sequence":"additional","affiliation":[{"name":"Groupe de Recherche en Transplantation et Immunologie du Sang de Cordon, Centre de Canc\u00e9rologie Charles-Bruneau , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Laboratoire d\u2019Immunologie du Sang de Cordon, Centre de Canc\u00e9rologie Charles-Bruneau , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Programme en Sciences Biom\u00e9dicales, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montr\u00e9al , Montreal, Quebec H3T 1J4,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo","family":"Cordeiro","sequence":"additional","affiliation":[{"name":"Groupe de Recherche en Transplantation et Immunologie du Sang de Cordon, Centre de Canc\u00e9rologie Charles-Bruneau , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Laboratoire d\u2019Immunologie du Sang de Cordon, Centre de Canc\u00e9rologie Charles-Bruneau , Montreal, Quebec H3T 1C5,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Caty","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d\u2019Immunopathologie Virale, Centre de Recherche du Centre Hospitalier Universitaire Sainte-Justine , Montreal, Quebec H3T 1C5,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira","family":"Mezziani","sequence":"additional","affiliation":[{"name":"Groupe de Recherche en Transplantation et Immunologie du Sang de Cordon, Centre de Canc\u00e9rologie Charles-Bruneau , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Service d\u2019H\u00e9mato-Oncologie, Centre Hospitalier Universitaire Sainte-Justine , Montreal, Quebec H3T 1C5,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Malette","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Microbiologie et Immunologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montr\u00e9al , Montreal, Quebec H3T 1J4,","place":["Canada"]},{"name":"D\u00e9partement de Microbiologie et Immunologie, Centre Hospitalier Universitaire Sainte-Justine , Montreal, Quebec H3T 1C5,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Duval","sequence":"additional","affiliation":[{"name":"Groupe de Recherche en Transplantation et Immunologie du Sang de Cordon, Centre de Canc\u00e9rologie Charles-Bruneau , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Laboratoire d\u2019Immunologie du Sang de Cordon, Centre de Canc\u00e9rologie Charles-Bruneau , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Service d\u2019H\u00e9mato-Oncologie, Centre Hospitalier Universitaire Sainte-Justine , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"D\u00e9partement de P\u00e9diatrie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montr\u00e9al , Montreal, Quebec H3T 1J4,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Alfieri","sequence":"additional","affiliation":[{"name":"Groupe de Recherche en Transplantation et Immunologie du Sang de Cordon, Centre de Canc\u00e9rologie Charles-Bruneau , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"D\u00e9partement de Microbiologie et Immunologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montr\u00e9al , Montreal, Quebec H3T 1J4,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Ovetchkine","sequence":"additional","affiliation":[{"name":"Groupe de Recherche en Transplantation et Immunologie du Sang de Cordon, Centre de Canc\u00e9rologie Charles-Bruneau , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"D\u00e9partement de P\u00e9diatrie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montr\u00e9al , Montreal, Quebec H3T 1J4,","place":["Canada"]},{"name":"Service des Maladies Infectieuses, Centre Hospitalier Universitaire Sainte-Justine , Montreal, Quebec H3T 1C5,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Le Deist","sequence":"additional","affiliation":[{"name":"Groupe de Recherche en Transplantation et Immunologie du Sang de Cordon, Centre de Canc\u00e9rologie Charles-Bruneau , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"D\u00e9partement de Microbiologie et Immunologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montr\u00e9al , Montreal, Quebec H3T 1J4,","place":["Canada"]},{"name":"D\u00e9partement de Microbiologie et Immunologie, Centre Hospitalier Universitaire Sainte-Justine , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"D\u00e9partement de P\u00e9diatrie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montr\u00e9al , Montreal, Quebec H3T 1J4,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Soudeyns","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d\u2019Immunopathologie Virale, Centre de Recherche du Centre Hospitalier Universitaire Sainte-Justine , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Groupe de Recherche en Transplantation et Immunologie du Sang de Cordon, Centre de Canc\u00e9rologie Charles-Bruneau , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"D\u00e9partement de Microbiologie et Immunologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montr\u00e9al , Montreal, Quebec H3T 1J4,","place":["Canada"]},{"name":"D\u00e9partement de P\u00e9diatrie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montr\u00e9al , Montreal, Quebec H3T 1J4,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,11,15]]},"reference":[{"key":"2025032409344756300_r1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s12016-011-8289-4","article-title":"Umbilical cord blood immunology: relevance to stem cell transplantation","volume":"42","author":"Lin","year":"2012","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"2025032409344756300_r2","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/sj.bmt.1703270","article-title":"Flow cytometric assessment of lymphocyte subsets, lymphoid progenitors, and hematopoietic stem cells in allogeneic stem cell grafts","volume":"28","author":"Theilgaard-M\u00f6nch","year":"2001","journal-title":"Bone Marrow Transplant."},{"key":"2025032409344756300_r3","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1182\/blood-2004-06-2467","article-title":"Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function","volume":"105","author":"Godfrey","year":"2005","journal-title":"Blood"},{"key":"2025032409344756300_r4","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1182\/blood.V88.3.795.795","article-title":"Successful transplantation of HLA-matched and HLA-mismatched umbilical cord blood from unrelated donors: analysis of engraftment and acute graft-versus-host disease","volume":"88","author":"Wagner","year":"1996","journal-title":"Blood"},{"key":"2025032409344756300_r5","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1182\/blood.V97.10.2962","article-title":"Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia","volume":"97","author":"Rocha","year":"2001","journal-title":"Blood"},{"key":"2025032409344756300_r6","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1182\/blood.V96.8.2703.h8002703_2703_2711","article-title":"Analysis of engraftment, graft-versus-host disease, and immune recovery following unrelated donor cord blood transplantation","volume":"96","author":"Thomson","year":"2000","journal-title":"Blood"},{"key":"2025032409344756300_r7","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.bbmt.2005.02.004","article-title":"Serious infections after unrelated donor transplantation in 136 children: impact of stem cell source","volume":"11","author":"Barker","year":"2005","journal-title":"Biol. Blood Marrow Transplant."},{"key":"2025032409344756300_r8","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1189\/jlb.0111007","article-title":"Complementary and contrasting roles of NK cells and T cells in pediatric umbilical cord blood transplantation","volume":"90","author":"Merindol","year":"2011","journal-title":"J. Leukoc. Biol."},{"key":"2025032409344756300_r9","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.bbmt.2008.05.006","article-title":"Varicella-zoster virus disease is more frequent after cord blood than after bone marrow transplantation","volume":"14","author":"Vandenbosch","year":"2008","journal-title":"Biol. Blood Marrow Transplant."},{"key":"2025032409344756300_r10","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.bbmt.2009.09.019","article-title":"Impact of cytomegalovirus (CMV) reactivation after umbilical cord blood transplantation","volume":"16","author":"Beck","year":"2010","journal-title":"Biol. Blood Marrow Transplant."},{"key":"2025032409344756300_r11","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.idc.2010.01.008","article-title":"Cytomegalovirus in hematopoietic stem cell transplant recipients","volume":"24","author":"Ljungman","year":"2010","journal-title":"Infect. Dis. Clin. North Am."},{"key":"2025032409344756300_r12","first-page":"1290","article-title":"High incidence of cytomegalovirus reactivation in adult recipients of an unrelated cord blood transplant","volume":"90","author":"Takami","year":"2005","journal-title":"Haematologica"},{"key":"2025032409344756300_r13","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1600-0609.2007.01006.x","article-title":"Impact of cytomegalovirus serostatus on outcome of unrelated cord blood transplantation for adults: a single-institute experience in Japan","volume":"80","author":"Tomonari","year":"2008","journal-title":"Eur. J. Haematol."},{"key":"2025032409344756300_r14","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.bbmt.2008.03.003","article-title":"Umbilical cord blood transplantation after reduced-intensity conditioning for elderly patients with hematologic diseases","volume":"14","author":"Uchida","year":"2008","journal-title":"Biol. Blood Marrow Transplant."},{"key":"2025032409344756300_r15","doi-asserted-by":"crossref","first-page":"173","DOI":"10.7326\/0003-4819-118-3-199302010-00003","article-title":"Ganciclovir prophylaxis to prevent cytomegalovirus disease after allogeneic marrow transplant","volume":"118","author":"Goodrich","year":"1993","journal-title":"Ann. Intern. Med."},{"key":"2025032409344756300_r16","doi-asserted-by":"crossref","first-page":"4063","DOI":"10.1182\/blood.V88.10.4063.bloodjournal88104063","article-title":"Cytomegalovirus pp65 antigenemia-guided early treatment with ganciclovir versus ganciclovir at engraftment after allogeneic marrow transplantation: a randomized double-blind study","volume":"88","author":"Boeckh","year":"1996","journal-title":"Blood"},{"key":"2025032409344756300_r17","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1182\/blood.V90.6.2502","article-title":"Neutropenia in allogeneic marrow transplant recipients receiving ganciclovir for prevention of cytomegalovirus disease: risk factors and outcome","volume":"90","author":"Salzberger","year":"1997","journal-title":"Blood"},{"key":"2025032409344756300_r18","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S1083-8791(03)00287-8","article-title":"Cytomegalovirus in hematopoietic stem cell transplant recipients: Current status, known challenges, and future strategies","volume":"9","author":"Boeckh","year":"2003","journal-title":"Biol. Blood Marrow Transplant."},{"key":"2025032409344756300_r19","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.bbmt.2006.12.454","article-title":"Cytomegalovirus infections following umbilical cord blood transplantation using reduced intensity conditioning regimens for adult patients","volume":"13","author":"Matsumura","year":"2007","journal-title":"Biol. Blood Marrow Transplant."},{"key":"2025032409344756300_r20","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1182\/blood-2003-10-3616","article-title":"The impact of cytomegalovirus serostatus of donor and recipient before hematopoietic stem cell transplantation in the era of antiviral prophylaxis and preemptive therapy","volume":"103","author":"Boeckh","year":"2004","journal-title":"Blood"},{"key":"2025032409344756300_r21","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.humimm.2004.02.022","article-title":"Clinical aspects of CMV infection after stem cell transplantation","volume":"65","author":"Hebart","year":"2004","journal-title":"Hum. Immunol."},{"key":"2025032409344756300_r22","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.bbmt.2007.06.006","article-title":"Cytomegalovirus infection after allogeneic transplantation: comparison of cord blood with peripheral blood and marrow graft sources","volume":"13","author":"Walker","year":"2007","journal-title":"Biol. Blood Marrow Transplant."},{"key":"2025032409344756300_r23","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1086\/342883","article-title":"Prevention of cytomegalovirus disease in hematopoietic stem cell transplantation","volume":"35","author":"Zaia","year":"2002","journal-title":"Clin. Infect. Dis."},{"key":"2025032409344756300_r24","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1182\/blood-2010-03-273508","article-title":"Immune monitoring with iTAg MHC Tetramers for prediction of recurrent or persistent cytomegalovirus infection or disease in allogeneic hematopoietic stem cell transplant recipients: a prospective multicenter study","volume":"116","author":"Gratama","year":"2010","journal-title":"Blood"},{"key":"2025032409344756300_r25","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.bbmt.2010.04.011","article-title":"Recovery of CMV-specific CD8+ T cells and Tregs after allogeneic peripheral blood stem cell transplantation","volume":"17","author":"Pastore","year":"2011","journal-title":"Biol. Blood Marrow Transplant."},{"key":"2025032409344756300_r26","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/bmt.2009.172","article-title":"Lack of prompt expansion of cytomegalovirus pp65 and IE-1-specific IFNgamma CD8+ and CD4+ T cells is associated with rising levels of pp65 antigenemia and DNAemia during pre-emptive therapy in allogeneic hematopoietic stem cell transplant recipients","volume":"45","author":"Tormo","year":"2010","journal-title":"Bone Marrow Transplant."},{"key":"2025032409344756300_r27","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1038\/bmt.2010.330","article-title":"Reconstitution of CMV pp65 and IE-1-specific IFN-\u03b3 CD8(+) and CD4(+) T-cell responses affording protection from CMV DNAemia following allogeneic hematopoietic SCT","volume":"46","author":"Tormo","year":"2011","journal-title":"Bone Marrow Transplant."},{"key":"2025032409344756300_r28","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1086\/648423","article-title":"Relationship of reconstituted adaptive and innate cytomegalovirus (CMV)-specific immune responses with CMV viremia in hematopoietic stem cell transplant recipients","volume":"49","author":"Barron","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"2025032409344756300_r29","doi-asserted-by":"crossref","first-page":"4111","DOI":"10.1182\/blood-2009-09-244145","article-title":"Clearance of CMV viremia and survival after double umbilical cord blood transplantation in adults depends on reconstitution of thymopoiesis","volume":"115","author":"Brown","year":"2010","journal-title":"Blood"},{"key":"2025032409344756300_r30","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1542\/peds.56.3.388","article-title":"Varicella in children with cancer: Seventy-seven cases","volume":"56","author":"Feldman","year":"1975","journal-title":"Pediatrics"},{"key":"2025032409344756300_r31","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S1083-8791(00)70004-8","article-title":"Varicella-Zoster virus: pathogenesis, immunity, and clinical management in hematopoietic cell transplant recipients","volume":"6","author":"Arvin","year":"2000","journal-title":"Biol. Blood Marrow Transplant."},{"key":"2025032409344756300_r32","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1471-2431-11-31","article-title":"Varicella-zoster virus infections in immunocompromised patients - a single centre 6-years analysis","volume":"11","author":"Wiegering","year":"2011","journal-title":"BMC Pediatr."},{"key":"2025032409344756300_r33","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.bbmt.2009.06.019","article-title":"Guidelines for preventing infectious complications among hematopoietic cell transplantation recipients: a global perspective","volume":"15","author":"Tomblyn","year":"2009","journal-title":"Biol. Blood Marrow Transplant."},{"key":"2025032409344756300_r34","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1001\/archinte.1982.00340150091017","article-title":"Immune responses to varicella-zoster in the aged","volume":"142","author":"Burke","year":"1982","journal-title":"Arch. Intern. Med."},{"key":"2025032409344756300_r35","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1056\/NEJM198207013070102","article-title":"Cytotoxic t cells in cytomegalovirus infection: HLA-restricted T-lymphocyte and non-T-lymphocyte cytotoxic responses correlate with recovery from cytomegalovirus infection in bone-marrow-transplant recipients","volume":"307","author":"Quinnan","year":"1982","journal-title":"N. Engl. J. Med."},{"key":"2025032409344756300_r36","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1182\/blood.V78.5.1373.1373","article-title":"Cytotoxic T-lymphocyte response to cytomegalovirus after human allogeneic bone marrow transplantation: pattern of recovery and correlation with cytomegalovirus infection and disease","volume":"78","author":"Reusser","year":"1991","journal-title":"Blood"},{"key":"2025032409344756300_r37","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1086\/379048","article-title":"Decline in varicella-zoster virus (VZV)-specific cell-mediated immunity with increasing age and boosting with a high-dose VZV vaccine","volume":"188","author":"Levin","year":"2003","journal-title":"J. Infect. Dis."},{"key":"2025032409344756300_r38","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1002\/eji.200737648","article-title":"Phenotypic analysis of human CD4+ T cells specific for immediate-early 63 protein of varicella-zoster virus","volume":"37","author":"Jones","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"2025032409344756300_r39","first-page":"185","article-title":"Long-term acyclovir prophylaxis in bone marrow transplant recipients and lymphocyte proliferation responses to herpes virus antigens in vitro","volume":"1","author":"Ljungman","year":"1986","journal-title":"Bone Marrow Transplant."},{"key":"2025032409344756300_r40","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/bjc.1989.88","article-title":"The prophylactic role of intravenous and long-term oral acyclovir after allogeneic bone marrow transplantation","volume":"59","author":"Selby","year":"1989","journal-title":"Br. J. Cancer"},{"key":"2025032409344756300_r41","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/j.bbmt.2008.09.004","article-title":"Recovery of varicella-zoster virus-specific T cell immunity after T cell-depleted allogeneic transplantation requires symptomatic virus reactivation","volume":"14","author":"Distler","year":"2008","journal-title":"Biol. Blood Marrow Transplant."},{"key":"2025032409344756300_r42","doi-asserted-by":"crossref","first-page":"4480","DOI":"10.1182\/blood-2011-04-349241","article-title":"CD8(+) T-cell reconstitution in recipients of umbilical cord blood transplantation and characteristics associated with leukemic relapse","volume":"118","author":"Merindol","year":"2011","journal-title":"Blood"},{"key":"2025032409344756300_r43","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/sj.bmt.1704433","article-title":"Results of an unrelated transplant search strategy using partially HLA-mismatched cord blood as an immediate alternative to HLA-matched bone marrow","volume":"33","author":"Dalle","year":"2004","journal-title":"Bone Marrow Transplant."},{"key":"2025032409344756300_r44","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/j.1399-3046.2007.00799.x","article-title":"Prevention of CMV disease in pediatric kidney transplant recipients: evaluation of pp67 NASBA-based pre-emptive ganciclovir therapy combined with CMV hyperimmune globulin prophylaxis in high-risk patients","volume":"12","author":"Renoult","year":"2008","journal-title":"Pediatr. Transplant."},{"key":"2025032409344756300_r45","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1002\/cyto.a.20643","article-title":"Phenotype and function of human T lymphocyte subsets: consensus and issues","volume":"73","author":"Appay","year":"2008","journal-title":"Cytometry A"},{"key":"2025032409344756300_r46","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1084\/jem.20011756","article-title":"Two subsets of naive T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood","volume":"195","author":"Kimmig","year":"2002","journal-title":"J. Exp. Med."},{"key":"2025032409344756300_r47","doi-asserted-by":"crossref","first-page":"3718","DOI":"10.1182\/blood-2009-10-251124","article-title":"Enumeration of human antigen-specific naive CD8+ T cells reveals conserved precursor frequencies","volume":"115","author":"Alanio","year":"2010","journal-title":"Blood"},{"key":"2025032409344756300_r48","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1002\/1521-4141(200006)30:6<1676::AID-IMMU1676>3.0.CO;2-V","article-title":"Analysis of CD8 T cell reactivity to cytomegalovirus using protein-spanning pools of overlapping pentadecapeptides","volume":"30","author":"Kern","year":"2000","journal-title":"Eur. J. Immunol."},{"key":"2025032409344756300_r49","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0163-7258(03)00034-2","article-title":"The human cytomegalovirus","volume":"98","author":"Landolfo","year":"2003","journal-title":"Pharmacol. Ther."},{"key":"2025032409344756300_r50","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1182\/blood-2003-03-0824","article-title":"Identification of novel CTL epitopes of CMV-pp65 presented by a variety of HLA alleles","volume":"103","author":"Kondo","year":"2004","journal-title":"Blood"},{"key":"2025032409344756300_r51","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.jaci.2003.07.003","article-title":"Lymphocyte subsets in healthy children from birth through 18 years of age: the Pediatric AIDS Clinical Trials Group P1009 study","volume":"112","author":"Shearer","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025032409344756300_r52","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1365-2141.2010.08409.x","article-title":"Lymphocyte subset reconstitution after unrelated cord blood or bone marrow transplantation in children","volume":"152","author":"R\u00e9nard","year":"2011","journal-title":"Br. J. Haematol."},{"key":"2025032409344756300_r53","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.immuni.2008.11.002","article-title":"Homeostasis of naive and memory T cells","volume":"29","author":"Surh","year":"2008","journal-title":"Immunity"},{"key":"2025032409344756300_r54","doi-asserted-by":"crossref","first-page":"6768","DOI":"10.1182\/blood-2011-02-334623","article-title":"Thymic T-cell development in allogeneic stem cell transplantation","volume":"117","author":"Krenger","year":"2011","journal-title":"Blood"},{"key":"2025032409344756300_r55","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/j.0105-2896.2006.00395.x","article-title":"Functional signatures of protective antiviral T-cell immunity in human virus infections","volume":"211","author":"Harari","year":"2006","journal-title":"Immunol. Rev."},{"key":"2025032409344756300_r56","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1002\/(SICI)1521-4141(199909)29:09<2908::AID-IMMU2908>3.0.CO;2-8","article-title":"Distribution of human CMV-specific memory T cells among the CD8pos. subsets defined by CD57, CD27, and CD45 isoforms","volume":"29","author":"Kern","year":"1999","journal-title":"Eur. J. Immunol."},{"key":"2025032409344756300_r57","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1182\/blood.V98.3.754","article-title":"Differentiation of cytomegalovirus-specific CD8(+) T cells in healthy and immunosuppressed virus carriers","volume":"98","author":"Gamadia","year":"2001","journal-title":"Blood"},{"key":"2025032409344756300_r58","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1086\/340637","article-title":"Cytomegalovirus (CMV) phosphoprotein 65 makes a large contribution to shaping the T cell repertoire in CMV-exposed individuals","volume":"185","author":"Kern","year":"2002","journal-title":"J. Infect. Dis."},{"key":"2025032409344756300_r59","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1086\/315347","article-title":"Frequencies of memory T cells specific for varicella-zoster virus, herpes simplex virus, and cytomegalovirus by intracellular detection of cytokine expression","volume":"181","author":"Asanuma","year":"2000","journal-title":"J. Infect. Dis."},{"key":"2025032409344756300_r60","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1086\/375828","article-title":"Identification of CD8+ T cell epitopes in the immediate early 62 protein (IE62) of varicella-zoster virus, and evaluation of frequency of CD8+ T cell response to IE62, by use of IE62 peptides after varicella vaccination","volume":"188","author":"Frey","year":"2003","journal-title":"J. Infect. Dis."},{"key":"2025032409344756300_r61","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.bbmt.2006.08.036","article-title":"Antigen-specific T-lymphocyte function after cord blood transplantation","volume":"12","author":"Cohen","year":"2006","journal-title":"Biol. Blood Marrow Transplant."},{"key":"2025032409344756300_r62","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.bbmt.2009.03.002","article-title":"Incidence, risk factors, and outcome of cytomegalovirus infection and disease in patients receiving prophylaxis with oral valganciclovir or intravenous ganciclovir after umbilical cord blood transplantation","volume":"15","author":"Montesinos","year":"2009","journal-title":"Biol. Blood Marrow Transplant."},{"key":"2025032409344756300_r63","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/sj.bmt.1705671","article-title":"Active CMV disease does not always correlate with viral load detection","volume":"40","author":"Ruell","year":"2007","journal-title":"Bone Marrow Transplant."},{"key":"2025032409344756300_r64","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1097\/01.TP.0000083894.61333.56","article-title":"Is the cytomegalovirus serologic status always accurate? A comparative analysis of humoral and cellular immunity","volume":"76","author":"Sester","year":"2003","journal-title":"Transplantation"},{"key":"2025032409344756300_r65","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1053\/gast.2002.33021","article-title":"Activated virus-specific T cells are early indicators of anti-CMV immune reactions in liver transplant patients","volume":"122","author":"Benz","year":"2002","journal-title":"Gastroenterology"},{"key":"2025032409344756300_r66","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1111\/j.1537-2995.2007.01420.x","article-title":"High prevalence of cytomegalovirus DNA in plasma samples of blood donors in connection with seroconversion","volume":"47","author":"Ziemann","year":"2007","journal-title":"Transfusion"},{"key":"2025032409344756300_r67","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1159\/000337039","article-title":"Early recovery of immunity after cord-blood transplantation in children: qualitative features and impact of cytomegalovirus infection","volume":"128","author":"Farnault","year":"2012","journal-title":"Acta Haematol."},{"key":"2025032409344756300_r68","doi-asserted-by":"crossref","first-page":"7853","DOI":"10.4049\/jimmunol.181.11.7853","article-title":"TCR beta-chain sharing in human CD8+ T cell responses to cytomegalovirus and EBV","volume":"181","author":"Venturi","year":"2008","journal-title":"J. Immunol."},{"key":"2025032409344756300_r69","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1182\/blood-2009-03-213256","article-title":"Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes","volume":"114","author":"Hanley","year":"2009","journal-title":"Blood"},{"key":"2025032409344756300_r70","doi-asserted-by":"crossref","first-page":"4658","DOI":"10.1073\/pnas.95.8.4658","article-title":"Latent varicella-zoster virus is located predominantly in neurons in human trigeminal ganglia","volume":"95","author":"Kennedy","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032409344756300_r71","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s15010-006-5616-9","article-title":"Loss of varicella zoster virus antibodies despite detectable cell mediated immunity after vaccination","volume":"34","author":"Ludwig","year":"2006","journal-title":"Infection"},{"key":"2025032409344756300_r72","first-page":"47","article-title":"Serology and serum DNA detection in shingles","volume":"138","author":"Dobec","year":"2008","journal-title":"Swiss Med. Wkly."},{"key":"2025032409344756300_r73","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1743-422X-7-54","article-title":"Early detection of Varicella-Zoster virus (VZV)-specific T-cells before seroconversion in primary varicella infection: case report","volume":"7","author":"Baiker","year":"2010","journal-title":"Virol. J."},{"key":"2025032409344756300_r74","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0168-1702(90)90006-W","article-title":"Antigenic cross-reaction between a varicella-zoster virus nucleocapsid protein encoded by gene 40 and a herpes simplex virus nucleocapsid protein","volume":"15","author":"Vafai","year":"1990","journal-title":"Virus Res."},{"key":"2025032409344756300_r75","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/0042-6822(86)90088-7","article-title":"Induction of neutralizing antibody against varicella-zoster virus (VZV) by VZV gp3 and cross-reactivity between VZV gp3 and herpes simplex viruses gB","volume":"149","author":"Kitamura","year":"1986","journal-title":"Virology"},{"key":"2025032409344756300_r76","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1128\/jvi.56.1.333-336.1985","article-title":"Cross-reactivity between herpes simplex virus glycoprotein B and a 63,000-dalton varicella-zoster virus envelope glycoprotein","volume":"56","author":"Edson","year":"1985","journal-title":"J. Virol."},{"key":"2025032409344756300_r77","doi-asserted-by":"crossref","first-page":"e1001051","DOI":"10.1371\/journal.ppat.1001051","article-title":"Contribution of herpesvirus specific CD8 T cells to anti-viral T cell response in humans","volume":"6","author":"Sandalova","year":"2010","journal-title":"PLoS Pathog."},{"key":"2025032409344756300_r78","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/sj.bjc.6605542","article-title":"IE63-specific T-cell responses associate with control of subclinical varicella zoster virus reactivation in individuals with malignancies","volume":"102","author":"Malavige","year":"2010","journal-title":"Br. J. Cancer"},{"key":"2025032409344756300_r79","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/infdis\/141.4.479","article-title":"Cell-mediated immunity to varicella-zoster virus after allogeneic marrow transplant","volume":"141","author":"Meyers","year":"1980","journal-title":"J. Infect. Dis."},{"key":"2025032409344756300_r80","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/infdis\/165.1.119","article-title":"Subclinical varicella-zoster virus viremia, herpes zoster, and T lymphocyte immunity to varicella-zoster viral antigens after bone marrow transplantation","volume":"165","author":"Wilson","year":"1992","journal-title":"J. Infect. Dis."},{"key":"2025032409344756300_r81","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1097\/TP.0b013e31824215db","article-title":"Diagnostic utility of human cytomegalovirus-specific T-cell response monitoring in predicting viremia in pediatric allogeneic stem-cell transplant patients","volume":"93","author":"Abate","year":"2012","journal-title":"Transplantation"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/189\/10\/5016\/61744230\/1201759.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/189\/10\/5016\/61744230\/1201759.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T08:56:19Z","timestamp":1743065779000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/189\/10\/5016\/7997743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":81,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,11,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1201759","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2012,11]]},"published":{"date-parts":[[2012,11]]}}}