{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:48:27Z","timestamp":1791204507228,"version":"4.2.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Galectin-1 (GAL1) is an S-type lectin with multiple functions, including the control of B cell homeostasis. GAL1 expression was reported to be under the control of the plasma cell master regulator BLIMP-1. GAL1 was detected at the protein level in LPS-stimulated B cells and was shown to promote Ig secretion in vitro. However, the pattern of GAL1 expression and function of GAL1 in B cells in vivo are still unclear. In this study, we show that, among B cells, GAL1 is only expressed by differentiating plasma cells following T-dependent or T-independent immunization. Using GAL1-deficient mice we demonstrate that GAL1 expression is required for the maintenance of Ag-specific Ig titers and Ab-secreting cell numbers. Using an in vitro differentiation assay we find that GAL1-deficient plasmablasts can develop normally but die rapidly, through caspase 8 activation, under serum starvation\u2013induced death conditions. TUNEL assays show that in vivo\u2013generated GAL1-deficient plasma cells exhibit an increased sensitivity to apoptosis. Taken together, our data indicate that endogenous GAL1 supports plasma cell survival and participates in the regulation of the humoral immune response.<\/jats:p>","DOI":"10.4049\/jimmunol.1201885","type":"journal-article","created":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T00:02:47Z","timestamp":1366848167000},"page":"5526-5533","source":"Crossref","is-referenced-by-count":43,"title":["Galectin 1 Modulates Plasma Cell Homeostasis and Regulates the Humoral Immune Response"],"prefix":"10.1093","volume":"190","author":[{"given":"Adrienne","family":"Anginot","sequence":"first","affiliation":[{"name":"Centre d\u2019Immunologie de Marseille-Luminy, Facult\u00e9 des Sciences de Luminy, Aix Marseille University, UM2 , Marseille F-13288,","place":["France"]},{"name":"INSERM, U1104 , Marseille F-13288,","place":["France"]},{"name":"Centre National de la Recherche Scientifique, UMR7280 , Marseille F-13288,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Espeli","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cambridge Institute for Medical Research, University of Cambridge ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Chasson","sequence":"additional","affiliation":[{"name":"Centre d\u2019Immunologie de Marseille-Luminy, Facult\u00e9 des Sciences de Luminy, Aix Marseille University, UM2 , Marseille F-13288,","place":["France"]},{"name":"INSERM, U1104 , Marseille F-13288,","place":["France"]},{"name":"Centre National de la Recherche Scientifique, UMR7280 , Marseille F-13288,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane J C","family":"Mancini","sequence":"additional","affiliation":[{"name":"Centre d\u2019Immunologie de Marseille-Luminy, Facult\u00e9 des Sciences de Luminy, Aix Marseille University, UM2 , Marseille F-13288,","place":["France"]},{"name":"INSERM, U1104 , Marseille F-13288,","place":["France"]},{"name":"Centre National de la Recherche Scientifique, UMR7280 , Marseille F-13288,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine","family":"Schiff","sequence":"additional","affiliation":[{"name":"Centre d\u2019Immunologie de Marseille-Luminy, Facult\u00e9 des Sciences de Luminy, Aix Marseille University, UM2 , Marseille F-13288,","place":["France"]},{"name":"INSERM, U1104 , Marseille F-13288,","place":["France"]},{"name":"Centre National de la Recherche Scientifique, UMR7280 , Marseille F-13288,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,6,1]]},"reference":[{"key":"2025032407015969200_r1","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/0092-8674(94)90498-7","article-title":"Galectins: a family of animal beta-galactoside-binding lectins","volume":"76","author":"Barondes","year":"1994","journal-title":"Cell"},{"key":"2025032407015969200_r2","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/nsb1294-863","article-title":"Crosslinking of mammalian lectin (galectin-1) by complex biantennary saccharides","volume":"1","author":"Bourne","year":"1994","journal-title":"Nat. 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Acta"},{"key":"2025032407015969200_r6","doi-asserted-by":"crossref","first-page":"137R","DOI":"10.1093\/glycob\/cwl025","article-title":"Galectin-1: a small protein with major functions","volume":"16","author":"Camby","year":"2006","journal-title":"Glycobiology"},{"key":"2025032407015969200_r7","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0304-4165(02)00315-X","article-title":"Galectins and cancer","volume":"1572","author":"Danguy","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"2025032407015969200_r8","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/nrc1527","article-title":"Galectins as modulators of tumour progression","volume":"5","author":"Liu","year":"2005","journal-title":"Nat. Rev. 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