{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:21:09Z","timestamp":1790234469089,"version":"4.1.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Galectin-3 (gal3) is known for its immunoregulatory functions in infectious, autoimmune, and inflammatory diseases. However, little is known about its regulatory role in the host\u2019s IL-17A response to infection. Using a mouse model of histoplasmosis in which both Th1 and Th17 responses contribute to fungal clearance, we investigated how gal3 regulates IL-17A responses. Our study showed that Histoplasma infection induced gal3\u2212\/\u2212 dendritic cells to produce significantly higher levels of IL-23, TGF-\u03b21, and IL-1\u03b2 than did gal3+\/+ cells. Infected by the same inoculum of Histoplasma, gal3\u2212\/\u2212 mice had lower fungal burden and produced higher levels of IL-23\/IL-17\u2013axis cytokines and lower levels of IL-12 and IFN-\u03b3. Additionally, there was an increase in Th17 cells and a reduction in Th1 cells in infected gal3\u2212\/\u2212 mice. In vitro Th1\/Th17-skewing experiments excluded the intrinsic effect of gal3 on Th cell differentiation. Although neutrophils from both gal3+\/+ and gal3\u2212\/\u2212 mice produced IL-17A upon IL-23 stimulation, their contribution to IL-17A production was greater in gal3\u2212\/\u2212 mice than in gal3+\/+ mice. Compared with gal3+\/+ dendritic cells, adoptive transfer of gal3\u2212\/\u2212 dendritic cells resulted in production of significantly higher levels of IL-17\u2013axis cytokines and reduced fungal burden. It appears that reduced fungal burden and preferential IL-17A response in gal3\u2212\/\u2212 mice by both Th17 cells and neutrophils were the result of preferential production of IL-23\/IL-17\u2013axis cytokines by dendritic cells. Our study showed that gal3 negatively regulates IL-17A responses through inhibition of IL-23\/IL-17\u2013axis cytokine production by dendritic cells.<\/jats:p>","DOI":"10.4049\/jimmunol.1202122","type":"journal-article","created":{"date-parts":[[2013,3,2]],"date-time":"2013-03-02T10:23:49Z","timestamp":1362219829000},"page":"3427-3437","source":"Crossref","is-referenced-by-count":63,"title":["Galectin-3 Negatively Regulates Dendritic Cell Production of IL-23\/IL-17\u2013Axis Cytokines in Infection by <i>Histoplasma capsulatum<\/i>"],"prefix":"10.1093","volume":"190","author":[{"given":"Sheng-Yang","family":"Wu","sequence":"first","affiliation":[{"name":"Graduate Institute of Immunology, National Taiwan University College of Medicine , Taipei, 10051","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhang-Sian","family":"Yu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Immunology, National Taiwan University College of Medicine , Taipei, 10051","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Tong","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Academia Sinica , Taipei, 11529","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Chuen","family":"Miaw","sequence":"additional","affiliation":[{"name":"Graduate Institute of Immunology, National Taiwan University College of Medicine , Taipei, 10051","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty A","family":"Wu-Hsieh","sequence":"additional","affiliation":[{"name":"Graduate Institute of Immunology, National Taiwan University College of Medicine , Taipei, 10051","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,4,1]]},"reference":[{"key":"2025032406481429700_r1","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.bbagen.2005.12.020","article-title":"Galectin-3: an open-ended story","volume":"1760","author":"Dumic","year":"2006","journal-title":"Biochim. 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